nematodes

Evolutionary theories of epigenetic drift

Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data My summary: Outside the context of food energy-dependent biophysically constrained pheromone-controlled viral latency, mutation accumulation (MA) and disposable soma (DS) provide possible explanations for the existence of human aging. For example, age-differentially-methylated sites across the genome showed significant MA-consistent increases in heritability with age or significant DS-consistent decreases in heritability. Their results supposedly show that both MA and DS play a role in explaining aging and aging-related changes but…

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Host-derived creation of all pathology (2 of 2)

Summary: All serious scientists know that all epigenetic diversity is food energy-dependent and biophysically constrained by the pheromone-controlled physiology of reproduction. See for comparison: Jay R. Feierman: “Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.” A Bacterial Messenger Molecule Extends Healthspan …indole,…

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Science journalists or paid propagandists? (4)

See first: Dobzhansky 1973 and precision medicine Prognostic value of the MicroRNA-29 family in multiple human cancers: A meta-analysis and systematic review   ….low expression of miR-29 is associated with aggressiveness and poor prognosis of malignant neoplasms. More importantly, miR-29 might serve as a key biomarker for predicting the recurrence and progression of human cancers. Feeding on the Unseen: Ingestion and Assimilation of Bacteriophages by Brachionus plicatilis (Rotifera) ATP Production Increases with Addition of Varying Concentrations of Vespa Amino Acid Mixture…

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Soil bacteria, bulls, cows, microRNAs, and mammary glands (2)

See also: Soil bacteria, bulls, cows, microRNAs, and mammary glands For comparison to everything known about how chemotaxis and phototaxis must be linked to supercoiled DNA via the nutrient-dependent pheromone-controlled physiology of reproduction in the context of the microRNA/messenger RNA balance and RNA-mediated cell type differentiation, see: Spectral Tuning of Killer Whale (Orcinus orca) Rhodopsin: Evidence for Positive Selection and Functional Adaptation in a Cetacean Visual Pigment Excerpt: Using codon-based likelihood models, we also found significant evidence for positive selection…

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Unified nutritional and molecular mechanisms

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits Article image: Excerpt: “…unifying nutritional and molecular mechanisms remain elusive.” Reported as Molecular mechanism behind health benefits of dietary restriction identified Excerpt 1) “Dietary restriction is a type of intervention that can include reduced overall food intake, decreased consumption of particular macronutrients such as protein, or intermittent bouts of fasting. It is known to have beneficial health effects, including protection from tissue injury and improved metabolism. It has also been…

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Eliminating correlations from evolutionary ecology

De novo creation of olfactory receptor genes clearly links food odors via amino acid substitutions to cell type differentiation in mosquitoes, and in nematodes, flies, honeybees, etc. It would be surprising if cause and effect did not extend to vertebrates from invertebrates. Indeed, Elekonich and Robinson (2000) linked our 1996 model of RNA-mediated cell type differentiation to hormone-organized and hormone-activated behavior in insects more than a decade ago. Since then, Vosshall’s lab has established the role that amino acid substitutions…

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More than a bag of chemicals?

From Fertilization to Adult Sexual Behavior (1996) Excerpt: “Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…” My comment: How far can this model of RNA-mediated cell type differentiation go? What links the model to ADHD? Could it be a single amino acid substitution (see below)? If so, can the response to ADHD pharmacotherapy be predicted by what is…

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Chromosomal rearrangements and ecological adaptations

PZ Myers is an atheistic biology teacher who believes in mutation-driven evolution. Myers thinks I am  “crank” and he compared me to John A. Davison, who Myers also thinks is a crank. According to Myers, Davison was a crank for proposing a theory that Evolution was all due to chromosome rearrangements… Discussion of who’s the crank ensured with more misinformation than I have ever seen spread by evolutionary theorists and atheists across 740 posts to Myers blog. Every comment I made was…

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