neuroendocrinology

Energy-dependent self-organization and self repair

Energy-dependent autophagy links food odors and pheromones from the innate immune system and RNA-mediated feedback loops to the physiology of reproduction in all living genera via chromosomal inheritance. Transgenerational epigenetic inheritance is nutrient-energy-dependent and pheromone-controlled. That fact has been established in the extant literature since 1933, when Thomas Hunt Morgan won the Nobel Prize in Medicine, and Erwin Schrodinger shared the 1933 Prize in Physics with Paul A.M. Dirac. See for example: From Fertilization to Adult Sexual Behavior December 1996…

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From precis to pre-mRNA and proof of concept in F1, F2, F3

The Gene Ontology Handbook, edited by Christophe Dessimoz & Nives Škunca Open Access, Download it here See also: New trends in evolutionary biology: biological, philosophical and social science perspectives November 7-9, 2016 See also: BioGenomics 2017 – Global Biodiversity Genomics Conference February 21-23, 2017 See also: Using fast-acting temperature-sensitive mutants to study cell division in Caenorhabditis elegans Conclusion: The current limiting factor in using this technology is the availability of fast-acting ts alleles. Previous forward genetic screens for ts alleles…

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From Precis to Proof in 6000 years

Religious texts, such as The Holy Bible appear to be like a Precis of works from God. He seems to be explaining energy-dependent creation in the context of what is currently known to serious scientists about biophysically constrained RNA-mediated protein folding chemistry, healthy longevity and RNA-mediated biodiversity. God made it perfectly clear, in advance, that all miraculous biodiversity is energy-dependent. Energy as information is the theme that extends to the weekend resurrection of the bacterial flagellum in P. fluorscens. Biologically…

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Did evolution autophosphorylate your kinases? (2)

Hecatombic evolution Deep-Sea Viruses Destroy Archaea Excerpt: Given the enormous scale of deep-sea ecosystems, the results indicate that archaea-virus relationships could be a major contributor to global biogeochemical cycles. My comment:  I know that Anna Di Cosmo​ and John Hewitt​ are able to link virus-driven energy theft to all pathology in all living genera via the conserved molecular mechanisms they have already placed into their proper perspective on natural selection for energy-dependent codon optimality, which links the innate immune system…

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The tipping point? 50, 000 publications (2)

Pubmed.com “microRNA” Hedgehog signaling enables nutrition-responsive inhibition of an alternative morph in a polyphenic beetle Excerpt: Significance Complex, nongradual responses to environmental conditions are commonplace in nature and perhaps most extreme in polyphenic insects where continuous variation in nutrition experienced in early development gives rise to discrete alternative castes or morphs. This research shows that the hedgehog (Hh) pathway has acquired a novel and highly unusual role in the nutrition-dependent regulation of polyphenic development of a beetle. Experimental repression of…

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Juvenile hormone links atoms to ecosystems

A comparative perspective on epigenetics Excerpt 1) …adaptation and evolution emerge through network-wide responses to change at all levels of biological organisation, from proteins and membranes to organelles and cells, rather than being driven by individual genes. ‘Active causation resides in the networks, which includes many components for which there are no DNA templates’, says Noble, concluding that this novel approach provides ‘an integrated systems view of evolution’. Excerpt 2) ‘Active causation resides in the networks, which includes many components…

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Amino acid substitutions, stress, and human behavior

Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity Excerpt: …33% of the human population present a BDNF Val66Met SNP that leads to a valine-to-methionine substitution in the BDNF protein at codon 66, and this SNP has been associated with increased susceptibility to development of stress-related disorders (21, 22). Reported as: Newly discovered windows of brain plasticity may help with treatment of stress-related disorders Excerpt: The researchers also identified the molecule regulating…

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Hematopoiesis and practopoiesis

Practopoiesis A thought results primarily from an adjustment of the brain hardware, and not from a computation executed by that hardware. My comment: The adjustments of the brain hardware integrate RNA-mediated events that include gene duplication and fixation of amino acid substitutions. The nutrient-dependent gene duplications and substitutions link the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man via their physiology of reproduction. The idea that everything known about nutrient-dependent…

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The pseudoscientific nonsense of behaviorists

Neural Representations of Unconditioned Stimuli in Basolateral Amygdala Mediate Innate and Learned Responses Excerpt from their summary: …we establish that the activation of US-responsive cells in the BLA is necessary for the expression of a conditioned response. Neural representations of conditioned and unconditioned stimuli therefore ultimately connect to US-responsive cells in the BLA to elicit both innate and learned responses. My comment: They link the innate ability to respond to epigenetic effects of odors to the learned ability to respond to…

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MicroRNAs and the exposome

 MicroRNAs as Potential Signatures of Environmental Exposure or Effect: A Systematic Review Excerpt: Researchers are currently publishing extensive lists of miRNAs that are responsive to environmental exposures and showing their utility as biomarkers of effect. Future research should focus on identifying the molecular mechanism behind miRNA expression changes in response to exposure to determine whether the changes in miRNA expression are merely a symptom of the (patho)physiological processes the organism undergoes after exposure, or whether miRNAs are the drivers responsible…

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