neurogenic

Environmental selection is natural selection

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk was published on April 23, 2018 The ectodysplasin A receptor (EDAR) gene has a range of pleiotropic effects, including sweat gland density, incisor shoveling, and mammary gland ductal branching. The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to…

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Vulgar Antagonists vs Quantum Effects

Exosome Cargo Could Be Drug Target For Neuropathic Pain My discussion attempt was removed by Dfm Prime, who claims to be a patient advocate for those who are suffering from neurological insult. See: Works at Neurosensory Neuroregenerative Research Foundation Publication: Catechol-O-Methyl Transferase Inhibition Reduces Symptoms of Hallucinogen Persisting Perception Disorder See for comparison: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults In my model, fluoroquinolone use to kill gut bacteria sometimes kills the bacteria that…

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New Testament Book Cover Refutes Theistic Evolution

Video of Biology of the Book Goats, bookworms, a monk’s kiss: Biologists reveal the hidden history of ancient gospels Collins already had developed a method to identify ancient species by differences in the amino acid sequences of collagen and other proteins preserved in fossils. See: Protein power by Robert F. Service …methods to sequence amino acids lag behind DNA sequencing. The report of 300 million year old proteins is based on ridiculous theories that failed to include what was known about…

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Energy-dependent physical and biophysical constraints (5)

Summary: Emmy Noethe’s theorems were developed in the early 1900’s. Richard Feynman inadvertently or purposefully alluded to them as examples of human idiocy. Discover Magazine resurrected the examples of human idiocy in a 2017 article. For comparison, Choi et al., (2017) support the claims that intercellular and interkingdom communication is energy-dependent and controlled by the metabolism of food energy to pheromones. It is obvious that pheromones biophysically constrain the virus-driven degradation of messenger RNA. That fact links everything currently known…

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Energy-dependent hydrogen bonds in supercoiled DNA

Chirality Check Most biological macromolecules are homochiral, and enzymes help to maintain this state of affairs; for example, checkpoints ensure that only l-amino acids are incorporated into proteins during translation. The fixation of the only achiral amino acid, glycine in position 6 of the gonadotropin releasing hormone decapeptide protein links the nutrient energy-dependent pheromone-controlled physiology of reproduction from yeasts to humans. That fact about RNA-mediated protein folding chemistry is missing from the chirality check, It also is missing from representations…

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Model vs theory: Progress report!

On June 14, 2013, 1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model and 2) Mutation-Driven Evolution were published with divergent/opposite conclusions. 1) …the largest contributor to the development of our personal preferences may be the unconscious epigenetic effects of food odors and pheromones on hormones that organize and activate behavior. If so, the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to…

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Life history transitions and RNA-mediated survial

The Endospore-Forming Pathogen Bacillus cereus Exploits a Small Colony Variant-Based Diversification Strategy in Response to Aminoglycoside Exposure Conclusion:  Thus, consideration of SCVs as a new, yet unexplored lifestyle of B. cereus within the common ecological niches, in which antibiotic-active substances produced by competitive microorganisms, plants, and invertebrate/vertebrate vectors might potentially also induce this persistent life-form of B. cereus, opens a panoply of research questions to be followed up. Reported as: Lifestyle switching – Bacillus cereus is able to resist certain antibiotic therapies…

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MicroRNA-encoded behavior

MicroRNA-encoded behavior in Drosophila Editor’s summary: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene activity. They repress expression through complementary base pairing interactions with target messenger RNAs… My comment: If I were going to link biophysically constrained nutrient-dependent protein folding chemistry to biodiversity, I would start with nutrient energy-dependent base pair changes and link microbes to humans via the conserved molecular mechanisms of their epigenetically-effected RNA-mediated metabolic networks and genetic networks. For example, I would link vitamin C to…

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Protein folding and Google page rank

Pheromones.com has been on the first page of a Google search for “pheromones” for several months. See: https://www.google.com/?gws_rd=ssl#q=pheromones Today, RNA-mediated.com appeared on the first page of a Google search for “RNA mediated” See: https://www.google.com/?gws_rd=ssl#q=RNA+mediated My domains may remain in a key position for information dissemination, or they may be placed into the background by Google’s algorithms. In either case, it has become clear that RNA-mediated events link the nutrient-dependent pheromone-controlled physiology of reproduction to biodiversity in species from microbes to…

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Making sense of quotes scattered across disciplines

Speaking of Science November 2014’s selection of notable quotes By The Scientist Staff | November 1, 2014 My comment: The quotes are scattered from across disciplines, but can be linked to what is known about conserved molecular mechanisms of biologically-based cause and effect that, in context, make sense of them. 1) Cell type differentiation occurs via amino acid substitutions in the Ebola viruses. Identification of two amino acid residues on Ebola virus glycoprotein 1 critical for cell entry 2) What…

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