neuroscience

The origin of information (5,4,3,2,1)

Summary: These findings reveal a new GLU biosynthetic pathway, which could contribute to some of the sunlight-induced neurobehavioral changes. The claims about new biosynthetic pathways should be placed into the context of what is known about the energy-dependent origin of all pathways. Researchers may have solved origin-of-life conundrum …the conditions that produce nucleic acid precursors also create the starting materials needed to make natural amino acids and lipids. That suggests a single set of [light activated] reactions could have given…

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Polymaths and paradigm shifts: From Asimov to Bear (5)

Summary: Neil deGrasse Tyson and Lawrence Krauss are among those who have continued to substitute pseudoscientific nonsense for legitimate facts, which is what Hawking did in every book he ever wrote, and each time he made a spurious claim based on his abilities as a conniving theorist whose works still have not been confirmed-and-validated. Now that he is gone, others may proclaim the greatness of his intellect and lionize the magnitude of his influence because they also are biologically uninformed…

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Polymaths and paradigm shifts: from Asimov to Bear (4)

Saying Goodbye to the RNA World Theory RNA has a limited ability for catalysis compared to peptides, and would have struggled to maintain its catalytic activity under the changing temperature conditions of early Earth. Carter and Wills also argued that if an RNA world existed, it would have been unlikely for it to incorporate peptides later on. See for comparison: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)…

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The overwhelming ignorance of sex researchers (2)

Conclusion: There is a clear link from Estrogen receptor α polymorphism in individuals and in species with differences in behavioral phenotypes. The differences are food energy-dependent and RNA-mediated. The differences link the sense of smell and the pheromone-controlled physiology of reproduction in soil bacteria from The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression to the report on the Obligatory role of hypothalamic neuroestradiol during the estrogen-induced LH surge in female ovariectomized rhesus monkeys Reported…

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Evolutionary theories of epigenetic drift (3)

Researchers unite in quest for ‘standard model’ of the brain Modelled on big physics projects, the International Brain Lab will bring together some of the world’s pre-eminent neuroscientists to probe a single behaviour. Foraging The IBL will aim to generate and test unifying theories about how the brain encodes and computes information – seeking to come up with the equivalent of physicists’ standard model. See also: microRNA foraging See for example: The Drosophila foraging gene human orthologue PRKG1 predicts individual…

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Energy-dependent physical and biophysical constraints (7)

See first: Energy-dependent physical and biophysical constraints (6) Stems Cells in the Hypothalamus Slow Aging in Mice My comment to The Scientist Cai says microRNAs could be a potential mechanism by which hypothalamic neural stem cells have such wide-ranging effects on aging, yet he believes that neurogenesis may also be involved. See also: Feedback loops link odor and pheromone signaling with reproduction At least 10,000 neurons in 26 different brain areas appear to transmit signals directly to GnRH neurons.  GnRH…

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Mutations: the “driving force” behind human brain complexity?

Evolutionary Psychology Crap in New Scientist There is a reason why domestic violence is so widespread, says David Buss, an evolutionary biologist at the University of Texas in Austin: it carries a selective advantage, tied with reproductive success. Larry Moran wrote: There’s something seriously wrong with evolutionary psychology. And there’s something seriously wrong with respectable science magazines who promote this crap. Are the science magazines that promote this crap respectable? I lost respect for anyone who still uses de Vries…

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Chromatin: The structure of DNA

Update on Inflammation and Degenerative Brain Disease Excerpt: While mapping connections of neurons has become the holy grail of current neuroscience, it is clear that communication of neurons with many other types cells is, also, vitally important to every aspect of brain function. My comment: Understanding dementia was placed into the context of understanding how virus-driven energy theft alters the de novo creation of olfactory receptor genes and causes the loss of function that is linked to all pathology via…

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Anthetical conclusions (2)

From Fertilization to Adult Sexual Behavior (1996) …ribosomal proteins S4X and S4Y (rpS4X, rpS4Y) are produced by sexually dimorphic genes whose protein products are sexually dimorphic. This suggests the possibility of subtle nuances in the ribosomal translation of at least some mRNA, in certain cell types (Fisher et al.,1990; Zinn et al., 1994). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster…

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From angstroms to ecosystems

How a happy moment for neuroscience is a sad moment for science Systems neuroscience is celebrating a landmark, but one that shows the way we do science is broken. Excerpt: These data are the first complete set of neural activity recordings released before publication. No papers preceded it; not even a report. Nothing. Just: here you go guys, the fruits of the joint labour of around 100 people over 4 years.” My comment: They released the information on June 13,…

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