non-cell autonomous Archives

Conceptual critique: Innateness vs the death gene (1)

February 14, 2018

Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations

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Summary: The term innate is used in psychological explanations. The so-called explanations ignore facts about the light energy-dependent activation of endogenous substrates. The anti-entropic virucidal energy of sunlight links the endogenous substrates to biophysically constrained viral latency and healthy longevity via the physiology of reproduction in all living genera. “Proximate mechanisms” and “evolution” are terms used by biologically uninformed theorists. That fact becomes perfectly clear in the context of The conceptual critique of innateness (paywalled) One proposal is that innateness can…

The MicroRNAome Strikes Back: A Sokalian hoax (1)

January 22, 2018

James Kohl

Adaptations, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA Directed, RNA-directed DNA methylation

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Summary: How can this not be a Sokalian hoax? The creation of sunlight is not linked to anti-entropic virucidal energy-dependent cell-type-specific epigenetic modifications. The quantized energy-dependent epigenetic modifications include RNA-directed DNA methylation, histone modification, nucleosome remodeling and higher-order chromatin reorganization. Instead, the magic of non-cell autonomous DNA methylation in plants is placed into in the context of the cytosine residue in CG, CHG and CHH sequence contexts (where H represents A, T or C). See for comparison: Analysis of 6,515 exomes reveals…

The tipping point (revisted): 69,000 publications

January 20, 2018

James Kohl

Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA Directed, What's in the News

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See first: The tipping point (revisited): 68,000 publications December 21, 2017 On December 24, 2017, I started a “tweet” series on Twitter, which was designed to test the response to accurate information about RNA-mediated energy-dependent biophysically constrained viral latency. Nearly 80,000 impressions have led to few engagements and virtually no discussion during a time when almost 1000 additional published works have been indexed on the PubMed database. In my January 20, 2018 PubMed search for term “microRNA,” among nearly 69,000 results,…