noncoding RNA

Plenty of Room at the Bottom

Cryo-EM: Linking spatial and conformational constraints

On Darwin Day (2018) Carl Zimmer suggested use of the twitter hashtag #Istudyevolution to report whatever aspect of biology people were studying. For example, Richard Lenski reported that he studied adaptation in E. coli. When I told others that ecological adaptation is nutrient-dependent and pheromone-controlled in species from microbes to humans, he blocked me from seeing his comments. Evidently he did not want people to know that he had been studying ecological adaptation for more than 2 decades but reporting…

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Autophagy is the antiphage defense strategy (2)

2/15/17 Energy as information and constrained endogenous RNA interference (video) The 6.46 minute-long technical presentation (above) from the Precision Medicine Virtual Conference is difficult to understand.Thus, 10 months later, Nik Willmore asked: 12/24/17 What are your insights into CRISPR and mTOR, for a young audience? I’m not mocking you…yet, Humpty Dumpty. What is the basis of your unifying principle? Vibration? Bohmian morphogenetic fields? Modified Darwin? God? –Nik Willmore @nikwillmore 12/25/17 Replying to @nikwillmore @jhewitt123 God created the anti-entropic virucidal energy of sunlight and…

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Energy-dependent epigenetic translation to mRNA stability (6)

See: Energy-dependent epigenetic translation to mRNA stability (5) Five energy-dependent amino acid substitutions are linked to differences in RNA content and biodiversity in 4 mammalian species. Excerpt: Species- and tissue-specific variation in mt-tRNA incorporation into the mt-LSU was analyzed….  Analysis of porcine dermal fibroblasts (C), human osteosarcoma 143B cells (D), bovine cardiac tissue (E), and rat hepatic tissue (F) depicts the relative abundance of each mt-tRNA across fractions (ImageQuant software); represented as a percentage of the total signal. In my…

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UV light and non-coding RNA

UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene …these events underlie a switch to expression of short mRNA isoforms and preferential use of alternative last exons in a number of genes, including ASCC3. Intriguingly, the switch between ASCC3 isoforms occurs on more than one level, in that the long mRNA isoform encodes a protein, functioning in the context of the ASCC complex and required for maintaining transcriptional suppression in the late stages of…

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Teleophobes vs teleophiles: a recent history

  Teleology is a reason or explanation for something in function of its end, purpose, or goal. The teleological or physico-theological argument, also known as the argument from design, or intelligent design argument is an argument for the existence of God or, more generally, for an intelligent creator “based on perceived evidence of deliberate design in the natural or physical world” My comment: Teleophobes make weak arguments peppered with logical fallacies.  They do not make physico-theological arguments, which can be supported…

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NORAD: air defense and defense against genomic entropy

NORAD may refer to: North American Aerospace Defense Command… that provides aerospace… defense for North America Norwegian Agency for Development Cooperation Noradrenaline, a hormone and a neurotransmitter with multiple biological roles My comment: The modern use of radar includes air-defense systems and ocean surveillance systems.  High tech radar systems are designed to use the systems complexity of signaling and sensing to extract useful information from levels of very high noise.  In the context of protection from virus-driven genomic entropy use…

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RNA-mediated events: chromosomal rearrangements and genomic rearrangements

The Architecture of a Scrambled Genome Reveals Massive Levels of Genomic Rearrangement during Development Excerpt: “Genome-wide DNA rearrangements are most exaggerated in ciliates, particularly in the model organism Oxytricha trifallax, which programs not only DNA deletion, but also total reorganization, through RNA-mediated events (Fang et al., 2012; Nowacki et al., 2008). ” My comment: The RNA-mediated events that lead to DNA rearrangements were reported as: In one of nature’s innovations, a single cell smashes and rebuilds its own genome Excerpt:…

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