nutrient-dependent microRNAs

Molecular Diagnostics: What is unprotected life (3)

Researchers use sunlight to produce chemicals and energy Excerpt: “It has always been right beneath our noses, and yet no one has ever taken note: Photosynthesis by way of the sun doesn’t just allow things to grow; the same principles can be applied to break plant matter down, allowing the release of chemical substances. In other words, direct sunlight drives chemical processes. The immense energy in solar light can be used so that processes can take place without additional energy…

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NORAD: air defense and defense against genomic entropy

NORAD may refer to: North American Aerospace Defense Command… that provides aerospace… defense for North America Norwegian Agency for Development Cooperation Noradrenaline, a hormone and a neurotransmitter with multiple biological roles My comment: The modern use of radar includes air-defense systems and ocean surveillance systems.  High tech radar systems are designed to use the systems complexity of signaling and sensing to extract useful information from levels of very high noise.  In the context of protection from virus-driven genomic entropy use…

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RNA-mediated theory killers (3)

  Ghosts in the Genome How one generation’s experience can affect the next By Oliver J. Rando | December 1, 2015 My comment: “…epigenetic information carriers include covalent modifications to nucleotides and histones, providing a wide variety of mechanisms that enable organisms to transmit information extragenomically.” When this was placed into its proper perspective, it was used in a parody by researchers who know how atoms and ecosystems are linked by RNA-mediated cell type differentiation in all living genera. See: …

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RNA-mediated regulatory mechanisms link microbes to humans (3)

See also: RNA-mediated regulatory mechanisms link microbes to humans and RNA-mediated regulatory mechanisms link microbes to humans (2) Regulation of gene expression The effects of miRNA dysregulation of gene expression seem to be important in cancer.[10] For instance, in gastrointestinal cancers, a 2015 paper identified nine miRNAs as epigenetically altered and effective in down-regulating DNA repair enzymes.[11] The effects of miRNA dysregulation of gene expression also seem to be important in neuropsychiatric disorders, such as schizophrenia, bipolar disorder, major depressive…

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A two-faced protein enables RNA-mediated DNA repair (3)

See: A two-faced protein enables RNA-mediated DNA repair (2) See: A two-faced protein enables RNA-mediated DNA repair My comment: Attempts to place what is currently known about the links from atoms to ecosystems back into the context of neo-Darwinian pseudoscientific nonsense have been doomed to fail ever since Dobzhansky (1973) wrote: Nothing in Biology Makes Any Sense Except in the Light of Evolution. He linked nutrient-dependent amino acid substitutions to cell type differentiation across species and also claimed “…the so-called…

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A two-faced protein enables RNA-mediated DNA repair (2)

A two-faced protein enables RNA-mediated DNA repair See also: Abundant contribution of short tandem repeats to gene expression variation in humans (subscription required) Excerpt: …suggesting that STRs have a key role in the evolution of expression. Indeed, several candidate gene studies in humans reported that STR variations modulate gene expression19,33–37 and alternative splicing… Reported as:  Researchers find repetitive DNA provides a hidden layer of functional information Excerpt:  He is calling these variants eSTRs, or expression STRs, to note that they…

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RNA-mediated everything

Odorant receptor gene choice and axonal wiring in mice with deletion mutations in the odorant receptor gene SR1 Abstract: In the mouse, a mature olfactory sensory neuron (OSN) of the main olfactory epithelium (MOE) expresses one allele of one of the 1200 odorant receptor (OR) genes in the genome. The mechanisms that underlie the one receptor–one neuron rule remain poorly understood. A popular experimental paradigm for OR gene choice is to delete an OR coding region by gene targeting or…

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A two-faced protein enables RNA-mediated DNA repair

Janus: …is the god of beginnings and transitions,[1] and thereby of gates, doors, doorways, passages and endings. He is usually depicted as having two faces, since he looks to the future and to the past. My comment: Nutrient-dependent beginnings of morphological and behavioral diversity are biophysically constrained by the physiology of species-specific RNA-mediated DNA repair in the context of reproduction. Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains Excerpt: Despite barely conserved primary sequences (Supplementary Fig.…

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Models are not theories (1)

Cells or Animals: Which model is better? Excerpt: …animal models allow testing on intact physiological systems of many cell types simultaneously. Excerpt:  …it is important to note that human and rodent physiology is not identical, and even sophisticated animal models can have shortcomings. My comment: For comparison to neo-Darwinian theories, it is more important to note that the RNA-mediated cell type differentiation of all living genera is nutrient-dependent and controlled by the physiology of reproduction. Also note, in species from…

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The virome, microbiome, replisome and supercoiled DNA

First Complete Pictures of Cells’ DNA-Copying Machinery Excerpt: This architecture could also potentially play an important role in developmental biology by providing a pathway for treating the two daughter strands differently. Many modifications to DNA, including how it is packaged with other proteins, control which of the many genes in the sequence are eventually expressed in cells. An asymmetric replisome may result in asymmetric treatment of the two daughter strands during cell division—an essential step for making different tissues within…

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