nutrient-dependent

Energy-dependent maternal-to-zygotic transition

Small Non-coding RNAs Associated with Viral Infectious Diseases of Veterinary Importance: Potential Clinical Applications ON 11/14/16 The co-author Mohamed Samir wrote:  Because our article is among the top 25% most viewed and downloaded articles in the third quarter of 2016 in “Frontiers in Veterinary Science”, The editor of the journal has invited me to host and moderate a new research topic in his journal about miRNAs in veterinary filed. Thanks God. The topic is virtually guaranteed to bring out the…

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Pheromone-controlled autophagy

Reporting new theories of evolution that fail to address facts about how energy-dependent changes link angstroms to ecosystems via chromosomal rearrangements in all living genera is like reporting old theories that have been invalidated by experimental evidence of biologically-based cause and effect. See for example:  2016-04-20 Roberto Cazzolla Gatti. A conceptual model of new hypothesis on the evolution of biodiversity, Biologia (2016). DOI: 10.1515/biolog-2016-0032 2016-05-17 David Enard et al. Viruses are a dominant driver of protein adaptation in mammals, eLife…

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Virus-mediated hecatombic evolution

Virus-mediated archaeal hecatomb in the deep seafloor These findings provide new evidence for a possible link between viral infections and chemoautotrophic production in the microbial food web. My comment: I hereby stake my claim to the invention of the term”hecatombic evolution.” At the forthcoming meeting of the Royal Society next month, I expect full consideration to be given to use of “hecatombic evolution” to replace neo-Darwinian evolution and/or the “Modern Synthesis” or mutation-driven evolution until everyone in the world realizes…

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Nutrient-dependent autophagy

Autophagy: cellular and molecular mechanisms Excerpt: Autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress. Autophagy also plays a housekeeping role in removing misfolded or aggregated proteins, clearing damaged organelles, such as mitochondria, endoplasmic reticulum and peroxisomes, as well as eliminating intracellular pathogens. My comment: Autophagy is energy-dependent See for example: Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency…

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Chromatin: The structure of DNA (3)

See:  Chromatin: The structure of DNA (2) Inherited parental methylation shifts over time, may have functional effects in the brain and other tissues Excerpt: …researchers have theorized that inherited methylation, also referred to as parental imprinting, largely remains stable throughout development, except during two important developmental milestones: after fertilization and during the creation of sperm and egg cells. Altered gene imprinting at other times has been associated with developmental disorders and cancer. My comment: Theorists have historically failed to learn…

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Chromatin: The structure of DNA

Update on Inflammation and Degenerative Brain Disease Excerpt: While mapping connections of neurons has become the holy grail of current neuroscience, it is clear that communication of neurons with many other types cells is, also, vitally important to every aspect of brain function. My comment: Understanding dementia was placed into the context of understanding how virus-driven energy theft alters the de novo creation of olfactory receptor genes and causes the loss of function that is linked to all pathology via…

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Hydrogen-atom energy in DNA base pairs

See also: Consciousness is simply food rearranged Role of Double Hydrogen Atom Transfer Reactions in Atmospheric Chemistry Abstract excerpt:  Hydrogen atom transfer (HAT) reactions are ubiquitous and play a crucial role in chemistries occurring in the atmosphere, biology, and industry. My comment: The link from physics to chemistry and the conserved molecular mechanisms of biologically-based RNA-mediated cell type differentiation has been the focus my works for more than 20 years, even before I knew what I would need to explain…

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Light energy-dependent active motifs

Active Motif claims that Active Motif is the industry leader in developing and delivering innovative tools to enable epigenetics and gene regulation research. See how the role of light is portrayed in LightSwitch™ Luciferase Assay System (with my emphasis) Excerpt 1) Combined with our large collection of miRNA Mimics and Inhibitors, you have everything needed to study miRNA-3´UTR interactions, validate miRNA targets, measure RNA stability, translation efficiency and the functional impact of miRNAs on a gene-by-gene basis. Excerpt 2) The…

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Light energy-induced base pair changes (2)

See: Light energy-induced base pair changes (1) To help others move forward via the concept of energy-dependent biophysically constrained RNA-mediated protein folding and what is known about how virus-driven energy theft is linked to all pathology, see also: Subatomic Particles, Part 1: Leptons Subatomic Particles, Part 2: Baryons, the Substance of the Cosmos Subatomic Particles, Part 3: Mesons If you are not ready to start from the de novo creation of the energy in a hydrogen atom, you may need…

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Light energy-induced base pair changes (1)

Semisynthetic organisms and synthetic biology Unintended Consequences of Expanding the Genetic Alphabet Conclusion: …phototoxicity results presented herein using a human skin cancer cell line are intended to create awareness to the scientific community of the potential unintended consequences of expanding the genetic alphabet with unnatural nucleosides like those used in this work. Reported as:  Unintended consequences of creating the world’s first semisynthetic organism Excerpt: …the artificial base pair makes living cells more susceptible to damage from low doses of sunlight and…

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