olfactory receptor genes

Tasting light links energy from creation to adaptation

The C. elegans Taste Receptor Homolog LITE-1 Is a Photoreceptor “In Brief: A taste receptor homolog absorbs UV light and mediates avoidance behavior in C. elegans in response to light exposure.” Excerpt: Light sensation is critical for all phyla of life, ranging from bacteria to humans (Wang and Montell, 2007; Yau and Hardie, 2009). Organisms have evolved various types of photoreceptor proteins… Photoreceptors are G protein-coupled receptors (GPCRs). No experimental evidence of biologically-based cause and effect links the evolution of any…

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Chromatin: The structure of DNA

Update on Inflammation and Degenerative Brain Disease Excerpt: While mapping connections of neurons has become the holy grail of current neuroscience, it is clear that communication of neurons with many other types cells is, also, vitally important to every aspect of brain function. My comment: Understanding dementia was placed into the context of understanding how virus-driven energy theft alters the de novo creation of olfactory receptor genes and causes the loss of function that is linked to all pathology via…

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Displays of ecological adaptation

A cinematic approach to drug resistance In a creative stroke inspired by Hollywood wizardry, scientists have designed a simple way to observe how bacteria move as they become impervious to drugs. The experiments are thought to provide the first large-scale glimpse of the maneuvers of bacteria as they encounter increasingly higher doses of antibiotics and adapt to survive—and thrive—in them. My comment: The nutrient-dependent pheromone-controlled ecological adaptations were reported as if mutation-driven evolution of bacteria had occurred. See for comparison:…

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The Origin of Information (2)

See also: The Origin of Information (1) Labroots Neuroscience virtual event: RNA mediated molecular epigenetics and virus driven entropy (working title: The Origin of Information) Published to Youtube March 2, 2016 RNA mediated molecular epigenetics and virus driven entropy Presented March 16 and 17, 2016  Login for free and go to the Poster Hall section on Neuron Biology for a full screen display of the poster or view the poster on Figshare Abstract: Energy-dependent molecular epigenetics support Einstein’s complete molecular…

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RNA methylation

This is a brief history of events that led me to found the domain RNA-mediated.com with some follow-up on the latest news about cell type differentiation In 2012, I attended this minisymposium 006.Transcribing Memories: New Mechanisms of Activity-Regulated Gene Expression and Their Roles in Experience-Dependent Plasticity. Description: Activity-regulated gene transcription is essential for orchestrating the gene expression programs that drive experience-dependent plasticity of neural circuits. Recent studies have not only vastly expanded our understanding of the mechanisms that mediate activity-regulated…

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Energy-dependent RNA methylation (6)

After I published Nutrient-dependent/pheromone-controlled adaptive evolution: a model, Lynnette Ferguson and Justin O’Sullivan invited me to submit this review of nutritional epigenetics for inclusion in a special issue of the journal “Nutrients.” Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (April 10, 2014) Abstract: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes…

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Countdown to Genetics and Genomics

RNA-mediated physics, chemistry, and molecular epigenetics (5) 5/10/16 Focus: Functional Implications of Human-Specific Changes in Great Ape microRNAs RNA-mediated physics, chemistry, and molecular epigenetics (4) 5/9/16 Focus: Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein RNA-mediated physics, chemistry, and molecular epigenetics (3) 5/9/16 Focus: Microtargeting cancer metabolism: opening new therapeutic windows based on lipid metabolism RNA-mediated physics, chemistry, and molecular epigenetics (2) 5/6/16 Focus: Micron-scale plasma membrane curvature is recognized by the septin cytoskeleton RNA-mediated physics, chemistry,…

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MicroRNAs and/or QTLs: Who buried what?

Making precision medicine a reality: Genomics researchers unveil road map to disease origin Excerpt: This study highlights the significance of mechanistic similarities for uncovering additional interacting downstream effectors of intergenic SNPs… My comment: Use of the term QTL may limit the understanding of how energy-dependent cell type differentiation occurs and how virus-driven energy theft is linked to all pathology. It would be great if someone would explain the difference between what QTLs do and what microRNA flanking sequences  do in…

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Wasted Templeton Funding (3)

See also: Wasted Templeton Funding (2) Templeton grant funds evolution rethink Excerpt: …parents can influence offspring not just through their DNA but by passing on the microorganisms they host or by transmitting epigenetic marks to subsequent generations. “Innovation may be a developmental response that becomes stabilized through genetic changes,” explains Armin Moczek, an evolutionary developmental biologist at Indiana University, Bloomington. My comment: He has not explained how nutrient energy-dependent changes in base pairs link hydrogen-atom transfer in solutions from microRNA…

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Molecular Diagnostics: What is unprotected life (4)

Pado, a fluorescent protein with proton channel activity can optically monitor membrane potential, intracellular pH, and map gap junctions Excerpt: Nature has developed a vast array of voltage-responsive proteins. To improve our ability to optimize the voltage sensitivity, kinetics, and signal size of GEVIs, an in silico search strategy was developed to identify potential voltage-sensing proteins since new genomes are routinely being sequenced. The use of a conserved amino acid motif in the second transmembrane segment of the voltage-sensing phosphatase…

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