OXIDATIVE PHOSPHORYLATION

UV light, H2O, and epigenetic effects… (4)

Before submitting your scientific manuscript for peer review, ensure that your results are reproducible by rigorously validating reagents such as antibodies. 9/29/2020 Find out how: Knockout validation: Overcoming the perils of poor antibody specificity Also, remember to link God’s Creation of UV light and water from oxidative phosphorylation and helioribogenetics to biophysically constrained viral latency across kingdoms via the physiology of pheromone-regulated genetic processes, or you will be referred to as a “theorist.” The theorists are stuck with a failed…

Read More

Protonated RNA interference vs stupid theories (1)

Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 …microRNA maturation efficiency may be encoded in the intrinsic dynamic ensemble of primary and precursor microRNAs, providing a potential means of regulating microRNA biogenesis in response to environmental and cellular stimuli. See for comparison:  The landscape of host genetic factors involved in immune response to common viral infections 10/27/20 Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the genetic mechanisms of immune response…

Read More

microRNA-mediated quantum error correction (4)

I’ve posted presentation abstract submissions here because I anticipated they would not be selected for presentation. See: UV light, H2O, and epigenetic effects… (1) 9/25/20 Submitted by James V. Kohl on 9/25/20 for presentation during the Epigenetics – From Bench to Clinic session: RNA modifications and epitranscriptomics​​ Moderator Tony Kouzarides Conclusion: Theorists who ignore the role of nutrition in biophysically constrained viral latency are largely to blame for all extant diseases. 21 See for instance: The Secret Language of Cells:…

Read More

From optoribogenetics to HelioRiboGenetics (4)

The 2020 Nobel Laureates in Physiology or Medicine failed to link God’s Creation of energy-as-information in ultraviolet (UV) light and His Creation of water to biophysically constrained viral latency across kingdoms via oxidative phosphorylation and RNA interference. See for comparison: Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers 9/30/20 Conclusion The data indicate that PPMO have the ability to potently and specifically suppress SARS-CoV-2 growth and are promising candidates for further pre-clinical development. If the history of published…

Read More

From optoribogenetics to HelioRiboGenetics (2)

See first: From optoribogenetics to HelioRiboGenetics (1) For consistency see Abcam’s: Spotlight on Neuroscience [and the 2020 Nobel Prize for Physiology or Medicine] Abcam’s forthcoming live sessions Adult Neurogenesis  Building and Reparing the Brain Epigenetics in the Nervous System On-demand webinars Role of chronic inflammation in risk for neurodegenerative disorders: Alzheimer’s disease Autophagy and Neurodegeneration Chronic virus-driven inflammation perturbs epigenetic effects on energy-dependent microRNA-mediated autophagy, which prevents neurodegeneration. Attempts to discredit Judy A. MIkovits for her role in linking God’s…

Read More

Optoribogenetic-driven sympatric speciation (1)

For presentation during session: Polycomb and chromatin remodeling Historical perspective: Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes… Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at…

Read More

UV light, H2O, and epigenetic effects… (3)

Trump nominates conservative Amy Coney Barrett for Supreme Court She would be the only justice on the current court not to have received her law degree from an Ivy League school. The eight current justices all attended either Harvard or Yale. Most researchers at Harvard and Yale failed to admit, and failed to teach their students, that God’s Creation of UV light and water biophysically constrains viral latency across kingdoms via oxidative phosphorylation. They are being forced to tell the…

Read More

UV light, H2O, and epigenetic effects… (1)

See first: Coherently organized healthy longevity (4) UV light, H2O, and epigenetic effects affect behavior and sympatric speciation Submitted by James V. Kohl on 9/25/20 for presentation during the Epigenetics – From Bench to Clinic session: RNA modifications and epitranscriptomics​​ Moderator Tony Kouzarides Title: UV light, H2O, and epigenetic effects affect behavior and sympatric speciation James V. Kohl* MicroRNA.pro Introduction UV light-activated, H2O-dependent oxidative phosphorylation links microRNA-mediated epigenetic effects on organized genomes from bench to clinic.  For a historical perspective,…

Read More

The microRNA-mediated fight against COVID-19 (1)

History (1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013) …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. History (2) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014 unpublished) This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino…

Read More

Coherently organized healthy longevity (1)

A large-scale binding and functional map of human RNA-binding proteins [RBPs] 7/29/20 We describe the spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization. These data expand the catalogue of functional elements encoded in the human genome by the addition of a large set of elements that function at the RNA level by interacting with RBPs. Reported as: ENCODE consortium identifies RNA…

Read More