paradigm shift

Epistemic corruption (10)

Biosynthesis of cyanobacterin, a paradigm for furanolide core structure assembly 5/26/22 Full functional evaluation of the recombinant key enzymes in vivo and in vitro, individually and in concert, provided in-depth mechanistic insights into a streamlined C–C bond-forming cascade that involves installation of compatible reactivity at seemingly unreactive Cα positions of amino acid precursors. Our work extends the biosynthetic and biocatalytic toolbox for γ-butyrolactone formation, provides a general paradigm for furanolide biosynthesis and sets the stage for their targeted discovery, biosynthetic…

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microRNA-mediated election cycles (3)

See: microRNA-mediated election cycles (2) The most recent addition to the 124,062 indexed published works that mention ‘microRNA’ is A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine For background on this paradigm shift, see the following works: US Air Force Studying Impact of Exome Sequencing in Routine Care 10/19/17 The special considerations around fitness for duty and privacy make this a particularly challenging study to design and implement, but also an extremely important…

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microRNA-mediated quantum error correction (2)

What Fans of ‘Herd Immunity’ Don’t Tell You 10/19/20 …the White House has all but embraced herd immunity and has also poisoned the public with misinformation, making it all but impossible to get national, near-universal compliance with public health advice for the foreseeable future. Herd immunity exemplifies nutrient-dependent pheromone-controlled ecological adaptations, which annoys neo-Darwinian theorists and Big Bang cosmologists, especially those who also are Trump-haters. See for comparison: Robust Filtering and Noise Suppression in Intragenic miRNA-Mediated Host Regulation 9/21/20 Specifically,…

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Complexity: Routes and Patterns (1)

Physical foundations of biological complexity  “Routes and patterns of the evolution of complexity are poorly understood.” Serious scientists have linked differences in the competing energy of two photons from the proton motive force to biophysically constrained viral latency via the physiology of pheromone-controlled reproduction in species from microbes to humans. Ages 10+ can learn how serious scientists did this by playing the cell biology game “Cytosis.” It starts from the creation of the sun’s anti-entropic virucidal energy and links it…

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Pheromones biophysically constrain RNA-mediated biodiversity (1)

Elaine Morgan on paradigm shifts. Her view of the pseudoscientific nonsense touted by neo-Darwinian theorists and “Big Bang” cosmologists is humorous and she accurately represents what’s been happening to me and others like me for the past two decades. It’s what we expect. It’s your choice to keep laughing about it. See for comparison: Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest Reported as: Scientists have identified the metabolic pathway associated with heart…

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Synthetic RNA-based switches

Synthetic RNA-based switches for mammalian gene expression control Current Opinion in Biotechnology, Volume 48, December 2017, Pages 54–60 If you wait until December, 2017 to see this article in print, you will probably be among the last of those to have missed a two decades-old paradigm shift. The fact that these researchers created synthetic RNA-based switches attests to the fact that natural selection for energy-dependent codon optimality links what organisms eat to energy-dependent RNA-mediated amino acid substitutions. The substitutions help…

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Energy-dependent pheromone-controlled entropy (1)

Let’s make peer review scientific …peer review is often biased and inefficient. It is occasionally corrupt, sometimes a charade, an open temptation to plagiarists. Even with the best of intentions, how and whether peer review identifies high-quality science is unknown. It is, in short, unscientific. A recent PubMed search for more peer-reviewed articles that mention microRNA returned a link to this published work. “Genetic 3’UTR variation is associated with human pigmentation characteristics and sensitivity to sunlight” One energy-dependent variation links…

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Sunlight: the essence of precision medicine and world peace

See for review: The essence of precision medicine See for comparison: We not only reject Trump’s values and policies, we also renew our commitment to a future where both the church and the academy will foster attitudes and actions so that human beings and the whole of creation can thrive. We join our hearts, our minds, our voices, and our actions with those of religious believers–Christians, Jews, Muslims, and people of all faiths, as well as with secular people of…

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Light ‘drives’ adaptation; nothing ‘drives’ evolution (2)

See: Light ‘drives’ adaptation; nothing ‘drives’ evolution See also: Who rules the waves? – Viruses might just be bit players in the drama of the seas. Then again, they could be major actors Excerpt (from 1996):  Most consider viruses to be a legion of cripples, sterilised by ultraviolet radiation and rendered impotent by hosts that are largely immune to their threat. But a few researchers take the opposite view. And if they turn out to be right, viruses could radically…

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Demoncrats fight polycombic ecological adaptation

Comey sent Congress letter on Clinton emails despite DOJ warning it would breach policy Excerpt: …we don’t ordinarily tell Congress about ongoing investigations, but here I feel an obligation to do so given that I testified repeatedly in recent months that our investigation was completed,” Comey wrote, referring to the Bureau’s previous investigation into Clinton’s private email server. “I also think it would be misleading to the American people were we not to supplement the record. See also: 96. ‘The…

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