pathology Archives - Page 10 of 10

Viruses come alive: Tree of life pseudoscience

September 28, 2015

Adaptations, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, Pharmacogenomics, RNA Directed

See also: The creation and activation of GPCRs ‘Tree of life’ for 2.3 million species released This comment was removed from a “tree of life” discussion site by the “site staff.” In the context of anonymous “peer” review, the comment was removed for the following reason: PSEUDOSCIENCE, with an added threat that my account might be suspended in case of regular violations of the guidelines that led the “site staff” to remove this comment. Young earth creationists addressed the “Tree…

Viruses, amino acids, and somatic cell types

July 31, 2015

James Kohl

Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, RNA Directed

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Although the ultimate origins of RNA viruses are uncertain, it seems reasonable to assume that these infectious agents have a long evolutionary history, appearing with, or perhaps before, the first cellular life-forms (38). The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis… Perhaps the evolutionists have placed the cart before the horse on this issue, as proposed by several…

MicroRNA controlled growth and brain development

July 9, 2015

James Kohl

Adaptations, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, Variations

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Navigable networks as Nash equilibria of navigation games Nature Communications | Article Open Excerpt: Here we show that the ideal maximally navigable networks do share some basic structural properties with the Internet, E.coli metabolic network, English word network, US airport network, the Hungarian road network and a structural network of the human brain. Reported as: Researchers find the organization of the human brain to be nearly ideal Excerpt: “An optimal network in the brain would have the smallest number of…

Protein folding and Google page rank

June 30, 2015

James Kohl

Adaptations, Ecology, Human Pheromones, Model Organisms

No Comments

Pheromones.com has been on the first page of a Google search for “pheromones” for several months. See: https://www.google.com/?gws_rd=ssl#q=pheromones Today, RNA-mediated.com appeared on the first page of a Google search for “RNA mediated” See: https://www.google.com/?gws_rd=ssl#q=RNA+mediated My domains may remain in a key position for information dissemination, or they may be placed into the background by Google’s algorithms. In either case, it has become clear that RNA-mediated events link the nutrient-dependent pheromone-controlled physiology of reproduction to biodiversity in species from microbes to…

Creating and maintaining the human virome

June 5, 2015

James Kohl

Adaptations, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, Pharmacogenomics, RNA Directed

One Comment

Comprehensive serological profiling of human populations using a synthetic human virome Excerpt from the editor’s summary: Despite differences in the rates of exposure to specific viruses, the antibody responses in most individuals targeted the same viral epitopes. My comment: Received: Fri, 05 Jun 2015 14:19:20 -0400 From an even broader perspective, this may be a step forward towards linking viruses and viral microRNAs to entropic elasticity and the anti-entropic epigenetic effects of nutrient-dependent microRNAs to cell type differentiation via the…

Implicating microRNAs in cancer

March 9, 2015

James Kohl

Adaptations, Diseases & Disorders, Ecology

No Comments

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis Reported as: In vivo CRISPR-Cas9 screen sheds light on cancer metastasis and tumor evolution Excerpt: “Unexpectedly, the screen also implicated several microRNAs — small RNA segments that are functional in the cell. More experimental work remains to fully explore the genes and microRNAs uncovered in the screen.” It is the perturbed balance of viral microRNAs and nutrient-dependent microRNAs that obviously makes the difference between RNA-directed DNA methylation and…

Different physical locations and different molecular mechanisms of health and disease

September 29, 2014

James Kohl

Diseases & Disorders, Pharmacogenomics

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Reappraisal of known malaria resistance loci in a large multicenter study Abstract excerpt: “The finding that G6PD deficiency has opposing effects on different fatal complications of P. falciparum infection indicates that the evolutionary origins of this common human genetic disorder are more complex than previously supposed.” Reported as: Long term genetic study finds geographical differences in human immune response to malaria Excerpt: “…humans living in different physical locations have evolved different mechanisms for staving off the dreaded disease malaria.” My…

Stop evolutionary theorists. Kill cancers

September 25, 2014

James Kohl

Diseases & Disorders, Ecology, Pharmacogenomics

No Comments

Bacterial ‘communication system’ could be used to stop, kill cancer cells, study finds Excerpt: “During an infection, bacteria release molecules which allow them to ‘talk’ to each other,” said the lead author of the study. “Depending on the type of molecule released, the signal will tell other bacteria to multiply, escape the immune system or even stop spreading.” My comment: Nutrient-dependent cell type proliferation is pheromone-controlled during health and infections — and in other diseases and disorders. The conserved molecular…

Can epigenetic inheritance occur without concurrent changes in morphology AND behavior?

September 19, 2014

James Kohl

RNA Directed

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Heritable Histones Scientists show how roundworm daughter cells remember the histone modification patterns of their parents. By Ruth Williams | September 18, 2014 My comment: Strike three, your theories are out. Re: Strike 1) Combating Evolution to Fight Disease Strike 2) RNA and dynamic nuclear organization Strike 3) Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans Does anyone think this latest addition of experimental evidence on heritable histones is not just another thinly-veiled attempt to continue the fight against disease?…