pathology

The emergence of light as energy from a life-giving star

June 20, 2017
James Kohl
Adaptations, base editing, biophotonics, Ecology, Light Energy, Model Organisms, Physics, RNA editing, Variations
3 Comments

The Sun – our steady, reliable companion – tells a very different story up close “…a mesmerising, perspective-shaking glimpse at Earth’s life-giving star.” (video) Questions: 1) Did the energy in this life-giving star create itself? 2) How is hydrogen-atom transfer in DNA base pairs in solution biophysically constrained. 3) Who created the feedback loops that link the solar analemma from the time-space continuum to representations of biophysically constrained life and free will in the Mobius strip. 4) Was Linda Buck…

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MicroRNAs GnRH and the failure of sex research

June 16, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Summary: “The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression” accurately represents what is known about food energy-dependent RNA-mediated cell type differentiation in species from soil microbes to humans. MicroRNAs are not new players in the hypothalamic control of fertility and the effects of food odors and pheromones on microRNAs link energy-dependent changes in hormones to behavior. That fact was detailed two decades ago in our Hormones and Behavior review. Now see: [MicroRNAs: new players…

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What energy source do proteins prefer?

May 5, 2017
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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Quantized energy as information is the anti-entropic virucidal source of healthy longevity. All pathology is caused by virus-driven energy theft. Impact of cytosine methylation on DNA binding specificities of human transcription factors …many developmentally important proteins display preference for mCpG-containing sequences.   How do proteins display a preference for anything except food and codon optimality? Natural selection for quantized food energy-dependent codon optimality links the structure and function of supercoiled DNA to protection from virus-driven energy theft. That fact was…

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Energy-dependent microRNA biogenesis

May 4, 2017
James Kohl
Adaptations, Ecology, Human Pheromones, Model Organisms, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, Variations
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Published May 3, 2017 Genetic variation and RNA structure regulate microRNA biogenesis …primary sequence determinants and RNA structure are key regulators of miRNA biogenesis. Genetic variation aka primary sequence determinants are energy-dependent and RNA-mediated. Energy-dependent RNA methylation is an experience-dependent link from natural selection for energy-dependent codon optimality. Natural selection for energy-dependent codon optimality links ATP-dependent microRNA biogenesis to RNA biosynthesis. Ridiculous attempts to portray energy-dependent top-down causation as if genetic variation came first may continue for another 52 years.…

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Draining the academic swamp of parasites

May 3, 2017
James Kohl
Adaptations, Autophagy, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA-directed DNA methylation, Variations
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National Academies Revise Conflict of Interest Policy The proposed changes follow revelations in recent years that committee members preparing reports for the Academies did not disclose industry relationships. By Ashley P. Taylor | May 3, 2017 Excerpt: They are also thinking about including not only current activities and relationships, as they do now, but past ones when determining whether or not a committee member has a COI. See for comparison: Ian Hodder: Çatalhöyük, Religion & Templeton’s 25% My comment: Past…

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Dispensing with March for Science Dispatches (1)

April 24, 2017
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, RNA Directed
One Comment

Earlier today, Phillip from ATT repaired the splicings that were required to re-establish my energy-dependent internet access. I published 1000 posts to this blog before the April 22, 2017 March for Science. Most of the blog posts attest to the facts about energy-dependent alternative splicings of RNA that link chirality and autophagy to all biodiversity on Earth via the physiology of pheromone-controlled reproduction. See for comparison: March for Science: Dispatches from Washington, DC “The hope is somebody will listen. We’re…

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Viruses in pathogenic variants disrupt alternative splicings (2)

April 18, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, Cytosis, Diseases & Disorders, Ecology, Physics, RNA Directed, RNA interference, RNA methylation, RNA-mediated epigenetic regulation of gene expression
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Autophagy is activated by virus-driven energy theft. Click on the term “Autophagy” That fact is clear in the diagram of systems complexity and in my model. See for contrast:  Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors A key question in virology, that is potentially answerable using paleovirological analyses, is what caused the elimination of extinct viral lineages? Conclusion: The selection pressures acting on hsaHTenv, its orthologs and progenitors might have been complex. Loss of fusogenicity…

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Cytosis: Biology Content

April 4, 2017
James Kohl
Adaptations, Diseases & Disorders, Ecology, Light Energy, Model Organisms, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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  Help Me Write Some Biology Content Project Update #5: Cytosis: A Cell Biology Board Game by John Coveyou (Genius Games) Many of you have mentioned that you’d like to have an explanation of the biology behind Cytosis available… and I think that is an AWESOME plan. Every time I’ve taught the game to non-science players in the past, they say gameplay made even more sense (and was so much more enjoyable) when I explained the science as well. This…

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Cytosis: A Cell Biology Board Game

March 27, 2017
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA interference, RNA-directed DNA methylation, RNA-mediated gene silencing, Variations
One Comment

Cytosis: A Cell Biology Board Game A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses! 3/27/17 My comment: On March 24, 2017 this article was published in ‘Science.’ A conserved NAD+ binding pocket that regulates protein-protein interactions during aging The article linked virus-driven energy theft from hydrogen-atom transfer in DNA base pairs in solution to all pathology. On March 24, 2017 this article also was published in…

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Sal Giardina: apologetics revisited

March 27, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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March 26, 2017 Sal Giardina wrote: “James, I appreciate your responding to my posts but I would prefer that your input would be related to the content of the post.” My reply: If you do not want people to learn how my claims are linked to yours, please tell me that you intend to continue with apologetics rather the concept of energy as information. Apologetics: … the religious discipline of defending or proving the truth of religious doctrines through systematic…

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