pathology

Optogenetics: Let there be virucidal light!

NIH Awards $1.4M Grant to Support Optogenetics Research Excerpt: Synaptic plasticity, learning and memory are regulated by protein signaling in the brain. Many forms of learning disabilities and other mental diseases may be caused by abnormal protein signaling. To address these brain disorders and diseases, it is crucial to understand on a molecular level the underlying processes within the brain that are involved in learning and memory.” My comment: When someone like Anna Di Cosmo, John Hewitt or Bruce McEwen…

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Survivors of RNA-mediated terrorism

In Darwin’s Radio and Darwin’s Children, Greg Bear predicted there would be ecologically adapted survivors of the forthcoming viral apocalypse.  Could his “raw insight” help to save you, or help to save any of your loved ones who are not already dead? Or, is it too late for us all? See: “The Darwin Code: Intelligent Design without God” Excerpt:  Once again, evolution is a fresh territory, much larger than anyone thought. The Darwin code–the key to all of our new…

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Building delicious base pairs in class. It’s elementary Watson and Crick

 Candy DNA https://1.bp.blogspot.com/-72XtdR9SrgE/WC6D1cZx_TI/AAAAAAAAecg/bIVDL6mH4jE_HEJ8kxg16mzQj97tH5mkQCLcB/w400-h247-p/candy-chromosomes-Clinical-Laboratory-Blogspot-com.jpg Building delicious A- T and G – C pairs This might be the best way to show students that base pair changes are nutrient energy-dependent and biophysically constrained by autophagy in the context of the physiology of reproduction, which links them to chromosomes as the units of transgenerational epigenetic inheritance. For example, the educator could start by telling them that if the base pair changes were not biophysically constrained by the chemistry of RNA-mediated protein folding, the…

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Virus-driven mutation or amino acid substitution

A computer program just ranked the most influential brain scientists of the modern era Excerpt: “My first thought was, ‘Who could I tell without appearing immodest?’” he said. “I then realized the only people who would want to hear about this are my children!” My comment: Oxytocin-related peptides are 9-13 amino acids long, but they can be recognized in genomic sequences. That allows them to be placed into the context of claims that link the nutrient energy-dependent de novo creation…

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Epigenetically effected energy-dependent fluorescence (2)

We are just trying to understand your hypothesis. Peter Berean has wasted more of my time that nearly anyone else I have encountered, and he still claims my model is a hypothesis. On October 14, 2016 I asked: How can you or anyone else tell the difference between a secular humanist and an old earth creationist? For example, I can compare both sects to young earth creationists who have linked everything known about nutritional epigenetics to healthy longevity and everything…

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Epigenetics and autophagy vs mutations and evolution (7)

RNA interference (RNAi) fails to protect all cell types from virus-driven energy theft. The effect on some cell types cannot be controlled. That’s because nutrient energy-dependent endogenosymbiosis and the pheromones-controlled physiology of reproduction protect the organized genomes of species from microbes to humans. Billions of waster dollars have been spent with no end to the waste in sight — until the Trump administration stops it. As that begins to happen, see: tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence (open access)…

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Polycombic ecological adaptation as a science, not a theory

Multi-omic data integration enables discovery of hidden biological regularities   Excerpt: Tracing the central dogma of biology (left column), we can link specific data types (middle column) to explain each of these biological processes. In this work, novel biological regularities that relate these processes are discovered through: (i) primary omics data (top box, right column) and (ii) integration with GEMs (bottom box, right column).   Excerpt: The approach directly addresses the BD2K grand challenge and is made conceptually accessible by…

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Biological evolution as a philosophy, not a science

There is no indication in the abstracts that any of the presenters are going to address the facts that link quantised energy to polycombic ecological adaptation and virus-driven energy theft from hecatombic evolution to all pathology in all living genera. Virus-mediated archaeal hecatomb in the deep seafloor (2016) provides details on the hecatombin evolution of all patholgoy From Fertilization to Adult Sexual Behavior (1996) provides details on the polycombic ecological adaptation of all healthy longevity. For these experts to address…

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Did evolution autophosphorylate your kinases? (2)

Hecatombic evolution Deep-Sea Viruses Destroy Archaea Excerpt: Given the enormous scale of deep-sea ecosystems, the results indicate that archaea-virus relationships could be a major contributor to global biogeochemical cycles. My comment:  I know that Anna Di Cosmo​ and John Hewitt​ are able to link virus-driven energy theft to all pathology in all living genera via the conserved molecular mechanisms they have already placed into their proper perspective on natural selection for energy-dependent codon optimality, which links the innate immune system…

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Life is energy-dependent task management

See also: Life is energy-dependent task management (2) Press Release: The Nobel Prize in Chemistry 2016  for the design and synthesis of molecular machines Excerpt: They have developed molecules with controllable movements, which can perform a task when energy is added. My comment: When energy is added is the key to understanding healthy longevity in the context of popular information Popular information (link opens pdf) Excerpt: All chemical systems strive for equilibrium – a lower energy state – but this…

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