pathology

Hypothesis free pseudoscience vs facts (2)

See first: Hypothesis free pseudoscience vs facts (1) Kondrashov and Kondrashov study shows the complexities of evolution at the mitochondrial tRNA level Conclusion: “As compelling as the step-by-step model of Darwinian evolution is, it seems that at least for stems of mt-tRNAs a majority of substitutions involve population dynamics that allow a population to jump over a short but deep valley in fitness.” My comment: As I recall, de Vries defined “mutation” in the content of sudden jumps in morphological…

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Chromatin: The structure of DNA

Update on Inflammation and Degenerative Brain Disease Excerpt: While mapping connections of neurons has become the holy grail of current neuroscience, it is clear that communication of neurons with many other types cells is, also, vitally important to every aspect of brain function. My comment: Understanding dementia was placed into the context of understanding how virus-driven energy theft alters the de novo creation of olfactory receptor genes and causes the loss of function that is linked to all pathology via…

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Unconstrained mutations, Zika virus, Kallmann’s syndrome

Frequency and Types of Chromosomal Aberrations in the Patients with Hypogonadism Published December 11, 2014 Reported in Journals and Conferences on Genetics & Molecular Biology·Wednesday, September 7, 2016 See also: Epigenetics and Genetics of Viral Latency … viral latency is responsible for life-long pathogenesis and mortality risk… X Chromosome-Linked Kallmann Syndrome: Clinical Heterogeneity in Three Siblings Carrying an Intragenic Deletion of the KAL-1 Gene Received: December 18, 2002 Accepted: February 02, 2003 First Published Online: January 14, 2009 Kallmann syndrome…

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Protecting 4 billion people from virus-driven entropy

New England Biolabs® Announces 2016 Passion in Science Awards® Recipients Congratulations to Scott O’Neill for helping to protect the health of billions of people from virus-driven energy theft and genomic entropy by infecting mosquitoes with viruses before they can spread virus-caused pathology. Content is covered by one or more patents, trademarks and/or copyrights owned or controlled by New England Biolabs, Inc.  However, its use may require you to obtain additional third party intellectual property rights for certain applications. See also: Chris…

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Energy-dependent cellular communication

Communication shapes sensory response in multicellular networks Significance Cells routinely sense and respond to their environment, and they also communicate with each other. Exactly how communication impacts sensing remains poorly understood. We study a population of fibroblast cells that responds to a chemical stimulus (ATP) and communicates by molecule exchange. Combining experiments and mathematical modeling, we find that cells exhibit calcium oscillations in response to not only the ATP stimulus but also, increased cell–cell communication. Our results show that, when…

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Anthetical conclusions (2)

From Fertilization to Adult Sexual Behavior (1996) …ribosomal proteins S4X and S4Y (rpS4X, rpS4Y) are produced by sexually dimorphic genes whose protein products are sexually dimorphic. This suggests the possibility of subtle nuances in the ribosomal translation of at least some mRNA, in certain cell types (Fisher et al.,1990; Zinn et al., 1994). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster…

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Virus-driven downsizing of the human brain (3)

Is there anyone who is still touting neo-Darwinian pseudoscientific nonsense who understands how the transgenerational epigenetic inheritance of Zika virus damage must be linked to all energy-dependent RNA-mediated cell type differentiation or from the virus-driven degradation of messenger RNA to all pathology? Evolution 2016 Videos (Indexed) Youtube videos Posters See for comparison: Direct radiocarbon dating and genetic analyses on the purported Neanderthal mandible from the Monti Lessini (Italy) Conclusion: If materials from sites excavated long ago (e.g. Riparo Mezzena) are…

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Did “Nature” kill Steve Jobs?

See also: Energy-dependent RNA methylation (7) How cancer was created by evolution (revisited) Excerpt: Cell division in our bodies is very heavily controlled. For instance, when you were first growing your hands, some cells went through “cell suicide” – a process called apoptosis – to carve out the spaces between your fingers. My comment: Cell division is energy-dependent and the result is controlled by the physiology of reproduction in species from microbes to humans.  Energy-dependent RNA-mediated cell type differentiation must…

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RNA methylation, learning, memory and behavior,

Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice    Excerpt: Our findings suggest that m6A is regulated in an activity-dependent manner in the adult brain, and may function to fine-tune mRNA turnover during memory-related processes.   My comment: They cite: Alarcón CR, Lee H, Goodarzi H, Halberg N, Tavazoie SF (2015) N6-methyladenosine marks primary microRNAs for processing. Nature 519:482–485.   In the context of experience-dependent learning and memory, the authors link quantized energy…

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Innate immunity and multiplexing

Scientists Hope to Cultivate an Immune System for Crops by Carl Zimmer Excerpt: The complex microbial world in the soil may protect plants much like our immune system protects our bodies. My comment: The speed of light on contact with water links the sun’s quantized anti-antropic virucidal energy from the de novo creation of nucleic acid precursors to biophysically constrained RNA-mediated protein folding chemistry and supercoiled DNA, which protects all living genera from virus-driven energy theft and genomic entropy. See…

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