pathology

Amino acids and virus penetration

For an example of the ocean of information you must swim through to get to an important fact about virus-driven energy theft and all pathology, see: The bacteriophage ϕ29 tail possesses a pore-forming loop for cell membrane penetration (June 15, 2016) They cite “PrDOS: prediction of disordered protein regions from amino acid sequence” (2007). Excerpt: We have also developed a system to predict disordered regions from the amino acid sequence. Our system is composed of two predictors, that is, a…

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Masters of deception about nature (2)

See my other blog posts on RNA methylation Thanks for your review of How Can Physics Underlie the Mind?: Top-Down Causation in the Human Context (The Frontiers Collection) Others linked the sun’s anti-entropic virucidal energy from energy-dependent changes in hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects all organized genomes from virus-driven energy theft and genomic entropy. Ellis comments on at least one of Schrodinger’s claims from “What is Life?” but he largely ignores the…

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Masters of deception about nature

Masters of Physics in Nature Excerpt: This interaction raises the possibility that particle velocity information and electrical information, and interactions between them, can be encoded by a single hair.” It also raises the possibility that “electroreception is widespread in arthropods, fulfilling functions beyond the detection of floral electric fields. My comment: Energy-dependent microRNA flanking sequences linked all invertebrates to all vertebrates in the context of what was published as:  The phylogenetic utility and functional constraint of microRNA flanking sequences and…

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Cracking the Olfactory Code?

What a smell looks like Excerpt:  This experiment was created so scientists could study how animals and humans use smells to navigate their surroundings. That question forms the heart of a new $6.4 million project, sponsored by the National Science Foundation and the White House Brain Initiative, called Cracking the Olfactory Code. My comment to the PBS site: Re: “Smell was part of very ancient evolution…. Bacteria use olfaction, single-celled organisms use olfaction, worms use olfaction.” The de novo creation…

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RNA methylation, behavior, and disease

Epigenetics and Genetics of Viral Latency by Paul M. Lieberman (May 11, 2016)   My comment: Lieberman succinctly confirmed the fact that …viral latency is responsible for life-long pathogenesis and mortality risk… His simplistic conclusion also attests to the fact that there is no defined boundary between epigenetics and genetics. Epigenetic effects on metabolic networks must be linked to genetic networks via the energy-dependent innate immune system. That’s how all serious scientists knew they would need to link angstroms to ecosystems…

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Energy-dependent RNA methylation (9)

Epigenetics and How Our Decisions Affect Our DNA Excerpt (with my emphasis): With the Genetics and Genomics 2016 virtual conference now on demand, we are extending the genetics conversation into this month with a new infographic. Epigenetics has been in the news quite a bit lately as researchers have been able to learn more about its process and influences. It turns out that epigenetics is an ever-changing process within our cells, causing more rapid modification within a generation. Unlike standard…

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Energy-dependent RNA methylation (10)

Plexciton Dirac points and topological modes Reported as: Scientists design energy-carrying particles called ‘topological plexcitons’ Excerpt: This should eventually enable engineers to create plexcitonic switches to distribute energy selectively across different components of a new kind of solar cell or light-harvesting device. My comment: “Single-residue insertion switches the quaternary structure and exciton states of cryptophyte light-harvesting proteins” links their discovery to the complexity of energy-dependent epigenetically-effected biophysically constrained protein folding chemistry in all living genera. Two epigenetic traps are required…

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Energy-dependent RNA methylation (1)

“How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?” — Roger Penrose “We know, for instance, when we eat food nucleic acids can get into our cells. Also, there is a theory that our cells in the body keep sending out nucleic acids and one theory has it that it seems to correct the mistakes that other cells have suffered…

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Energy-dependent biodiversity (3)

Higher Abundance of Bacteria than of Viruses in Deep Mediterranean Sediments Conclusion: Results obtained in this study suggest that the number of viruses in deep-sea sediments might be dependent upon complex interactions with both abiotic factors (such as pressure, physical disturbance, and redox conditions) and biotic factors, including bacterial metabolic state and virus supply from the water column. Further studies are needed to clarify the causes of the low viral density, to estimate the actual impact of viruses on benthic…

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The tipping point? 50, 000 publications

There’s 10 trillion microbes on you; the White House wants to figure them out Excerpt: …start research into the microbes that shape life on Earth — including those in plants, animals, water, soil and air — as part of an effort to fight disease… “The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis…“– Eugene Koonin (May 7, 2015)  …

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