pathology

RNA-mediated physics, chemistry, and molecular epigenetics

RNA-mediated physics, chemistry, and molecular epigenetics Genetics and Genomics May 11-12, 2016 Published on 3 May 2016  See the full size poster displayed on Figshare.com Abstract: Olfaction and the innate immune system link energy as information from the epigenetic landscape to the physical landscape of supercoiled DNA. The sun’s biological energy is the source of the information that links angstroms to ecosystems via physics, chemistry, and molecular epigenetics. RNA-mediated protein folding chemistry and amino acid substitutions link the anti-entropic quantized…

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Ignore the evidence: Rachel Feltman

“There is incontrovertible evidence that Alzheimer’s Disease has a dormant microbial component. We can’t keep ignoring all of the evidence” –Professor Douglas Kell, Manchester University Experts Say There’s a Herpes-Alzheimer’s Link Excerpt: …herpes has been linked to damage in the central nervous system and the limbic system, which is associated with mental decline and personality changes, the Telegraph reported. The experts called for a deeper investigation into the connection. Calm down: Herpes probably isn’t going to give you Alzheimer’s Excerpt:…

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Virus-driven disorder prevention and health promotion

The dynamic epigenome and its implications for behavioral interventions: a role for epigenetics to inform disorder prevention and health promotion Excerpt: Evidence has also been growing about the role of epigenetic modification in response to the social environment. My comment: Unexpectedly, Szyf et al., (2016) fail to mention all the evidence of epigenetically-effected RNA-mediated cause and effect that has accumulated since we published our 1996 Hormones and Behavior review. That may explain why they also failed to link energy-dependent hydrogen-atom…

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Science vs semantics

Re-interpreting long-term evolution experiments — Is delayed adaptation an example of historical contingency or a consequence of intermittent selection? Excerpt: “… the series of events used to explain adaptation in the short-transfer LTEE (and in speciation) might need to be revised. The amplification model supported by this article has already be proposed as a means of evolving new genes (1) and has been experimentally shown capable of generating a novel genetic function within as few as 3000 cell generations (11).…

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Another failed rescue attempt

Social Darwinism, A Case of Designed Ventriloquism Excerpt:  In Wilson’s view, Social Darwinism “is perhaps the most important example of a term that became tainted and needs to be rescued.” According to him, from the very beginning, this term “was used as a pejorative to brand laissez faire policies that Darwin did not endorse. My comment: Darwin knew nothing about genetics. He stressed the fact that “conditions of life” must be placed before natural selection. Others ignored that fact and…

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Ecological genomics: teleophobes respond (too late)

Forecasting Ecological Genomics: High-Tech Animal Instrumentation Meets High-Throughput Sequencing Conclusion: Twenty years ago, an essay about sequencing genomes and remotely tracking animals across the globe in real time would have been the subject of science fiction. In 2015, there are over 50,000 animals being tracked [12], and single research groups now sequence dozens, up to hundreds, of individual genomes [17,82]. By embracing new technology and integrating these data streams into an ecological genomic framework (Fig 1), we are now poised…

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Finding peace and π in the light of H bond energy

It might be amusing if the misrepresentations of links between energy and cell type differentiation by people like PZ Myers were not going to cause more suffering and death.  Instead, two years after his attack on me for my accurate representations of the link from nutrient energy-dependent chromosomal rearrangements to pheromone-controlled biodiversity in species from microbes to humans we see this: You’re trying to explain a random phenotype by looking for a randomization mechanism in the genome. No one will…

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A two-faced protein enables RNA-mediated DNA repair (3)

See: A two-faced protein enables RNA-mediated DNA repair (2) See: A two-faced protein enables RNA-mediated DNA repair My comment: Attempts to place what is currently known about the links from atoms to ecosystems back into the context of neo-Darwinian pseudoscientific nonsense have been doomed to fail ever since Dobzhansky (1973) wrote: Nothing in Biology Makes Any Sense Except in the Light of Evolution. He linked nutrient-dependent amino acid substitutions to cell type differentiation across species and also claimed “…the so-called…

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Sensationalizing no new mechanism

Scientists discover new mechanism that protects brain stem cells against aging-induced damage Excerpt: Sebastian Jessberger says: This is an exciting new mechanism involved in stem cell division and aging. But as of now we are only just beginning to understand the molecular constituents and the true meaning of the barrier for stem cell division in the brain. One key question to be answered is whether the barrier is established in all somatic stem cells of the body. My comment: There…

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Cancer: forward and reverse

The convergent cancer evolution toward a single cellular destination Abstract excerpt: …cancer evolution is a directional process toward a defined cellular destination, a finding reconciling development and evolution, the two seemingly incompatible philosophies both adopted by the cancer research community, and also raising new questions to evolutionary biology. My comment: The idea that cancers evolve and the idea that species evolve are not compatible. Taken  together, the incompatible ideas that have been adopted by cancer researchers led to 32 years…

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