Pharmacogenomics

Evolution outside the context of “the light of evolution” (2)

See first: Evolution outside the context of “the light of evolution” How many proponents of Intelligent Design never learned that Darwinian evolution was based on his “conditions of life?” ch 4 IV. Natural Selection; or the Survival of the Fittest  “IF under changing conditions of life…” ch 5 http://www.bartleby.com/11/5002.html “…the greater variability of species having wider ranges than of those with restricted ranges, lead to the conclusion that variability is generally related to the conditions of life…” “…we cannot tell…

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The Origin of Information (3)

Summary: I presented two poster sessions during the Labroots virtual conference “Neuroscience,” March 16-17, 2016 One linked sunlight to energy as the origin of information. The other linked energy as information to biophysically constrained viral latency via the pheromone-controlled physiology of reproduction in all living genera. Additional experimental evidence of top-down causation has since confirmed that the creation of sunlight can be linked from energy as information to all biodiversity via its anti-entropic virucidal effects. The direct quantitative measurement of…

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RNA-mediated physics, chemistry, and molecular epigenetics

RNA-mediated physics, chemistry, and molecular epigenetics Genetics and Genomics May 11-12, 2016 Published on 3 May 2016  See the full size poster displayed on Figshare.com Abstract: Olfaction and the innate immune system link energy as information from the epigenetic landscape to the physical landscape of supercoiled DNA. The sun’s biological energy is the source of the information that links angstroms to ecosystems via physics, chemistry, and molecular epigenetics. RNA-mediated protein folding chemistry and amino acid substitutions link the anti-entropic quantized…

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Pathology: Eating and breathing viruses

RNA viruses can hijack vertebrate microRNAs [miRNAs] to suppress innate immunity Excerpt: The extent of sequence complementary between the miRNA and mRNA leads to control of mRNA-encoded polypeptide levels by either a block in translation, degradation of the mRNA, or both5, 6. For RNA viruses, limited evidence exists for host miRNAs binding to viral RNAs and restricting infection or affecting disease1, 7, 8. In the excerpt above, the host miRNAs offer nutrient-dependent protection against viral RNAs. Earlier blog posts on…

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A “new” code enables ecological adaptation

Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity Reported as: Discovery of new code makes reprogramming of cancer cells possible Excerpt: …an unexpected new biology that provides the code, the software for turning off cancer,” says the study’s senior investigator, Panos Anastasiadis, Ph.D., chair of the Department of Cancer Biology on Mayo Clinic’s Florida campus. That code was unraveled by the discovery that adhesion proteins — the glue that keeps cells together —…

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Is the best Chinese research from China?

8 and great: the best Chinese research of 2015 in Genome Biology Excerpt 1) They found that the relationship between mRNA and protein levels is increasingly unlinked during aging. This occurrence is likely caused by modifications to the mRNA that alter stability, or prevent translation into proteins. Many of the genes that were predicted to be targeted for these modifications are known to be involved in lifespan extension, mitochondrial function, and Alzheimer’s disease. My comment: The modifications to the mRNA…

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Viruses, amino acids, and somatic cell types (3)

A co-author of our 1996 Hormones and Behavior review of hormone-organized and hormone-activated behaviors gave her permission to add additional items of interest to this series of blog posts about viruses, amino acids, and somatic cell types. Teresa Binstock is largely responsible for my knowledge of RNA-mediated cell type differentiation. She introduced me and others to the complexity in the section of our review with the title Molecular epigenetics. Excerpt: It is now understood that certain genes undergo a process…

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MicroRNA controlled growth and brain development

Navigable networks as Nash equilibria of navigation games Nature Communications | Article  Open Excerpt: Here we show that the ideal maximally navigable networks do share some basic structural properties with the Internet, E.coli metabolic network, English word network, US airport network, the Hungarian road network and a structural network of the human brain. Reported as: Researchers find the organization of the human brain to be nearly ideal Excerpt: “An optimal network in the brain would have the smallest number of…

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microRNAs and memory: Why trust a theory?

Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems Abstract excerpt: … links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding… manifested in increasing organismal complexity… My comment: The increasing organismal complexity attributed to microRNAs is manifested in the learning abilities and in the memory of…

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Creating and maintaining the human virome

Comprehensive serological profiling of human populations using a synthetic human virome Excerpt from the editor’s summary: Despite differences in the rates of exposure to specific viruses, the antibody responses in most individuals targeted the same viral epitopes. My comment: Received: Fri, 05 Jun 2015 14:19:20 -0400 From an even broader perspective, this may be a step forward towards linking viruses and viral microRNAs to entropic elasticity and the anti-entropic epigenetic effects of nutrient-dependent microRNAs to cell type differentiation via the…

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