phenotypes

Quantized energy-dependent viral trophism (2)

See first: Quantized energy-dependent viral trophism Summary of Quantized energy-dependent viral trophism (2) WTH*? The species evolved to F*- itself? (H*eck) (*Fertilize) Rapid genome shrinkage in a self-fertile nematode reveals sperm competition proteins Science  05 Jan 2018 …we compared chromosome-scale assemblies of the outcrossing nematode Caenorhabditis nigoni to its self-fertile sibling species… The chromosome-scale assemblies extend across species to the fact that a difference in the diet of P. pacificus links its pheromone-controlled physiology of reproduction from C. elegans to…

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Who created your virus-driven death gene? (2)

Evolution of Constrained Gonadotropin-releasing Hormone Ligand Conformation and Receptor Selectivity These findings indicate that the substitution of glycine for a chiral amino acid in GnRH during evolution allows a more constrained conformation for receptor binding and that this subtle single amino acid substitution in a site remote from the ligand functional domains has marked effects on its structure and activity. The difference between an energy-dependent RNA-mediated amino acid substitution and a mutation has been largely ignored as pseudoscientists linked accidents…

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The overwhelming ignorance of sex researchers

Summary: J. Michael Bailey, and others like him, pretend to not know how non-coding variants are epigenetically linked from differences in hydrogen bonds to all energy-dependent biophysically constrained morphological and behavioral phenotypes. Genome-Wide Association Study of Male Sexual Orientation [Energy-dependent changes in biophysically constrained viral latency] We identified several [energy-dependent changes in] SNPs with p < 10−5, including regions of multiple supporting SNPs on chromosomes 13 (minimum p = 7.5 × 10−7) and 14 (p = 4.7 × 10−7). The genes nearest to these peaks have functions plausibly relevant to…

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Trump’s appeal to common sense (2)

See: Trump’s appeal to common sense Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation To our knowledge, this is the first study to use a genetic mouse model to simultaneously map Gpr182 localization patterns and elucidate novel physiological functions for the negative regulation of intestinal proliferative capacity, especially during regeneration and adenoma formation. Future studies to identify the ligand for this exciting and physiologically relevant orphan GPCR [G protein-coupled receptor] will shed light on its tractability as…

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Dobzhansky 1973 and precision medicine

MicroRNA-34 directly targets pair-rule genes and cytoskeleton component in the honey bee Our findings point to miR-34-5p as novel regulatory component in the complex molecular cascade that governs insect segmentation and to a broader role of miRNAs in the early development due to the detection of mature transcripts from both 5p and 3p arms for several precursor miRNAs. Thus, this work encourages further investigation to pinpoint miRNAs as fine tuners of insect early development. Anna Di Cosmo‘s group took the…

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Epigenetics and autophagy vs mutations and evolution (7)

RNA interference (RNAi) fails to protect all cell types from virus-driven energy theft. The effect on some cell types cannot be controlled. That’s because nutrient energy-dependent endogenosymbiosis and the pheromones-controlled physiology of reproduction protect the organized genomes of species from microbes to humans. Billions of waster dollars have been spent with no end to the waste in sight — until the Trump administration stops it. As that begins to happen, see: tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence (open access)…

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Epigenetics and autophagy vs mutations and evolution (6)

Bird embryos uncover homology and evolution of the dinosaur ankle Conclusion: The early formation of the limb skeleton is often assumed to be well known from ‘classic’ published lines of work using traditional techniques and model species. However, it is worth revising this basic information. New methods and better taxon sampling can provide increased detail and substantial revision, with important evolutionary implications. In addition to the fossil record, reliable embryological data from birds are important to understand their evolution from…

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Polycombic ecological adaptation as a science, not a theory

Multi-omic data integration enables discovery of hidden biological regularities   Excerpt: Tracing the central dogma of biology (left column), we can link specific data types (middle column) to explain each of these biological processes. In this work, novel biological regularities that relate these processes are discovered through: (i) primary omics data (top box, right column) and (ii) integration with GEMs (bottom box, right column).   Excerpt: The approach directly addresses the BD2K grand challenge and is made conceptually accessible by…

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Did evolution autophosphorylate your kinases? (3)

Did evolution autophosphorylate your kinases? (1) Did evolution autophosphorylate your kinases? (2) See also: N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection Reported as: Chemical tags affect ability of RNA viruses to infect cells Dynamics of Human and Viral RNA Methylation during Zika Virus Infection Reported as:  Zika virus infection alters human and viral RNA My comment: Virus-driven hecatombic evolution of all pathology is linked from the failure of energy-dependent phosphorylation to biophysically constrain the RNA-mediated damage to DNA via…

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Chromatin: The structure of DNA (2)

A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation Excerpt (with my emphasis): Highlights •    A histone H4K20me1-specific live-cell probe, H4K20me1-mintbody, was developed. •    Dynamics and replication timing of Xi were visualized. •    Critical amino acids for the stability and/or folding of the mintbody were revealed. Reported as: Catching histones by the tail: A new probe to track histone modifications in living cells Excerpt: H4K20me1 is most likely associated with the tight packing of a redundant (inactivated) female X…

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