Physiopathology

Misunderstanding cancer

Tumor-Only Genetic Sequencing May Misguide Cancer Treatment in Nearly Half of All Patients, Study Shows Excerpt 1) “…they counted 382 possible tumor-related changes. But after comparing a patient’s full germline genome to his or her tumor genomes, they determined that, on average, 249 of these changes were part of the patient’s normal, inherited genetic variation and were not tumor-specific.” Excerpt 2) “In addition to selecting personalized therapies for patients with cancer, sequencing the normal tissue genome can also increase the…

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Origin of life and cancer (1,2,3)

1) On the Origins of Life The physics of the light-induced de novo creation of the amino acids was placed into the context of  ‘cyanosulfidic’ protometabolic systems chemistry. The systems chemistry links substitution of achiral glycine in the gonadotropin releasing hormone (GnRH) decapeptide to the biophysically constrained nutrient dependent RNA-mediated chemistry of protein folding in all vertebrates. The role of food odors and hormone-controlled cell type differentiation in all vertebrates also links changes in the balance of viral microRNAs and…

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RNA-mediated “repurposing” is nutrient-dependent and pheromone-controlled

 Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system Excerpt: The fast-spreading strain AR2F had acquired an additional point mutation in the σ54-dependent EBP gene ntrC, which alters an amino acid (R442C) within the DNA binding domain (Table 1 and table S2). Reported as: Evolutionary Rewiring Strong selective pressure can lead to rapid and reproducible evolution in bacteria. By Ruth Williams | February 26, 2015 Excerpt: NtrC shares 30 percent amino acid identity with FleQ, suggesting the…

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An epigenetic trap (the prequel)

See also: An epigenetic trap (the sequel) Excerpt: “Support for the link from one epigenetic trap to cell type differentiation was included in the molecular epigenetics section of our 1996 review, which detailed how RNA-mediated chromatin remodeling occurs.” My comment: One epigenetic trap leads to the de novo creation of olfactory receptor genes and cell type differentiation. See also: Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons. The first epigenetic trap links the sun’s biological energy to cell type…

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The anti-entropic force of "Nature"

Exploring the Epigenome A National Institutes of Health-funded consortium publishes 111 reference maps of DNA and histone marks. By Jenny Rood | February 18, 2015 Excerpt:  “All our cells have a copy of the same book, but they’re all reading different chapters, bookmarking different pages, and highlighting different paragraphs and words.” These chemical bookmarks, such as methylation and acetylation, help control which genes are transcribed into RNA and expressed in a given cell type, thus aiding the maintenance of a…

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Military combat training to fight disease

Q: What is the extent of your formal scientific education? I see that you attended the University of Nevada at some point. A: I had already been trained in the military to combat evolutionary theory (see also Combating Evolution to Fight Disease). After time spent in the hospital medical records department, I became the liaison between people who were being processed for medical discharge and the Medical Evaluation Board, I organized case histories that included all testing and learned about…

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Epigenetic effects of viruses on cellular homeostasis (2)

TSLive: The Enemy Within (video) How viruses wield tiny molecules of RNA to help them persist in our bodies for years, decades, and sometimes an entire life span By The Scientist Staff | February 1, 2015 This brief video (below) packages an exceptional amount of information. In less than 2 minutes, it links the epigenetic effects of viral microRNAs to the differentiation of all cell types in all individuals of all species via the innate ability of immune system regulation…

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Are viruses microRNAs? (2)

The role of microRNAs in cell type differentiation can be compared in the context of the role of viruses and mutations that cause cancer. Facts provide a basis for explaining the biological basis of epigenetically-effected cell type differentiation in species from microbes to man. But first, those who are biologically uninformed must answer the question: Are viruses microRNAs? Andrew Jones aka anonymous_9001 is correct. Viruses are not microRNAs. anonymous_9001 5 / 5 (6) 11 hours ago Stupid question of the…

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