plasticity

Light, behavior and autophagy, a gender-specific risk factor

Structure of photosystem II and substrate binding at room temperature Excerpt: PS II, a membrane-bound multi-subunit pigment protein complex, couples the one-electron photochemistry at the reaction centre with the four-electron redox chemistry of water oxidation at the Mn4CaO5 cluster in the oxygen-evolving complex (OEC). New, detailed snapshots capture photosynthesis at room temperature The living machinery responsible for photosynthesis – while commonplace and essential to life on Earth – is still not fully understood. It is understood at every level of…

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Light ‘drives’ adaptation; nothing ‘drives’ evolution (3)

See also Light ‘drives’ adaptation; nothing ‘drives’ evolution (2) 100 feet below the surface bioluminescent organisms are the dominant light source, study shows Excerpt: “Luminescent marine organisms each have a unique light signature. By looking at the time series light generated by a flash within the instrument, we were able to determine who was there making the flash,” Cohen explained. “It’s a useful tool, particularly at this time of year when relatively few species are present.” Bioluminescence is known to…

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The last RNA-mediated theory killer (2)

Autophagy (epigenetically effected by nutrient-energy and controlled by the physiology of reproduction) See for comparison: Virus-driven energy theft and epigenetically-effected autophagy Selleck Chem product use citations Excerpts: Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Inhibitors of cellular kinases with broad-spectrum antiviral activity for hemorrhagic fever viruses. A causal link from ALK to hexokinase II overexpression and hyperactive glycolysis in EML4-ALK-positive lung cancer. The number of citations to published works that link the use of…

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Hypothesis free pseudoscience vs facts (5)

See first: Hypothesis free pseudoscience vs facts (4) Re: There is literally nothing left of neo-Darwinian pseudoscientific nonsense, and yet pseudoscientists still make the same ridiculous claims. See for comparison:  Current Drug Design Studies for Hsp70 in Oncological Applications SBD [substrate binding domain] contains hydrophobic amino acid residues, and this hydrophobic cavity helps unfolded substrate proteins to fold their native structure. Thus, exposed part of the folded proteins may not interact with each other and cause aggregation [in the context…

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Base pairs, olfaction and RNA thermometers

RNA thermometer controls temperature-dependent virulence factor expression in Vibrio cholerae (2014) Excerpt: The stem-loop can be stabilized by strengthening the base pairing between the fourU element and SD sequence through the substitution of G-C base pairs, and this results in an elevated melting temperature (10). Conclusion: RNA thermometers represent a simple yet elegant mechanism for controlling temperature-dependent gene expression and may be more widespread among pathogenic bacteria that interact with mammalian hosts than is currently known. See also:  MicroRNA Stability…

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Hydrogen-atom energy in DNA base pairs

See also: Consciousness is simply food rearranged Role of Double Hydrogen Atom Transfer Reactions in Atmospheric Chemistry Abstract excerpt:  Hydrogen atom transfer (HAT) reactions are ubiquitous and play a crucial role in chemistries occurring in the atmosphere, biology, and industry. My comment: The link from physics to chemistry and the conserved molecular mechanisms of biologically-based RNA-mediated cell type differentiation has been the focus my works for more than 20 years, even before I knew what I would need to explain…

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Antithetical conclusions (4)

Evidence for sex-specific genetic architectures across a spectrum of human complex traits …will need to disentangle whether sex genetic heterogeneity may arise as a consequence of interactions with genetic loci located on the sex chromosomes, differences in gene control due to differences in the sex-specific cellular environment, or more general differences in environmental exposures between the sexes. Nutrient energy-dependent pheromone-controlled sex differences in the cell types of species from yeasts to humans link changes in the microRNA/messenger RNA balance and…

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Antithetical conclusions (3)

Local modulation of chemoattractant concentrations by single cells: dissection using a bulk-surface computational model This is part of the Theme issue ‘Coupling geometric partial differential equations with physics for cell morphology, motility and pattern formation’ Excerpt: “The computed ligand concentration and receptor occupancy on the evolving cell membrane are shown in figure 5.” Conclusion: “…the detailed information gained through simulations of single cells or the interaction of a few cells could be used to better inform agent-based approaches and the…

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Anthetical conclusions

Something is antithetical when it is in complete and utter opposition to the character of something. Analysis of protein-coding genetic variation in 60,706 humans reported as: Largest collection of human exome sequence data yields unprecedented tool for diagnosing rare disease …variation that was expected, but not found, in the data offered new insight. Some genes were found to have less than the expected number of missense mutations, which change the protein sequence, or “loss-of-function” mutations, which obliterate protein function. With…

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Non-random pheromone-controlled cell type differentiation

Experience-Dependent Plasticity Drives Individual Differences in Pheromone-Sensing Neurons Aug 17, 2016   •Individual differences in cell types are not random •Sex differences in pheromone-sensing neurons are controlled by experience •Changes in specific cell types are governed via “use it and lose it” plasticity •Targeting plasticity to specific cell types changes animal behavior This was reported as: Long-term exposure to female scents changes courtship behavior in male mice The senior author co-authored Chromatin remodeling inactivates activity genes and regulates neural coding…

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