polycombic ecological adaptations

UV light, H2O, and epigenetic effects… (1)

September 25, 2020
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Physics, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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See first: Coherently organized healthy longevity (4) UV light, H2O, and epigenetic effects affect behavior and sympatric speciation Submitted by James V. Kohl on 9/25/20 for presentation during the Epigenetics – From Bench to Clinic session: RNA modifications and epitranscriptomics​​ Moderator Tony Kouzarides Title: UV light, H2O, and epigenetic effects affect behavior and sympatric speciation James V. Kohl* MicroRNA.pro Introduction UV light-activated, H2O-dependent oxidative phosphorylation links microRNA-mediated epigenetic effects on organized genomes from bench to clinic.  For a historical perspective,…

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pH-dependent viral latency (1)

May 22, 2020
James Kohl
Adaptations, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA Directed, RNA interference
One Comment

Four back-to-back articles in Science Magazine on May 15, 2020 attest to facts about how God’s Creation of energy-as-information was linked to all biodiversity on Earth via President Donald J. Trump’s claim about UV light and facts about light activated microRNA biogenesis, which biophysically constrains viral latency via the pH-dependent physiology of reproduction.   1) Modeling infectious disease dynamics The current pandemic has no parallel…, but the new virus is following rules common to other pathogens. The so-called “rules” are…

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Less evolvable RNA-mediated ecological adaptations

March 29, 2018
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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No experimental evidence of biophysically constrained RNA-mediated cell type differentiation supports the claim about “…the evolutionary plasticity of the regulatory regions involved in transcriptional regulation…” The overwhelming systems complexity of energy-dependent RNA-mediated cause and effect can no longer be placed into the context of the pseudoscientific nonsense touted by theorists. Watch Andrea Wagner’s group try to escape from the claims made by losers. But first see: Kalevi Kull: Censorship & Royal Society Evo Event Nobody wants to belong to the…

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Achromobacter and killer theories

November 14, 2017
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Variations
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A pan-genomic approach to understand the basis of host adaptation in Achromobacter  Ecological variation is linked to food energy-dependent biophysically constrained viral latency by the pheromone-controlled physiology of reproduction in species from microbes to humans. For comparison, these authors claim: This study provides strong phylogenetic and pan-genomic bases to motivate further research on Achromobacter, and contributes to the understanding of opportunistic pathogen evolution. Their claim exemplifies how teaching neo-Darwinian theory causes unnecessary suffering and how it may cause the premature…

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Sal Giardina: apologetics revisited

March 27, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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March 26, 2017 Sal Giardina wrote: “James, I appreciate your responding to my posts but I would prefer that your input would be related to the content of the post.” My reply: If you do not want people to learn how my claims are linked to yours, please tell me that you intend to continue with apologetics rather the concept of energy as information. Apologetics: … the religious discipline of defending or proving the truth of religious doctrines through systematic…

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RNA editing refutes theistic evolution

February 21, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Physics, RNA Directed, RNA editing, RNA-directed DNA methylation, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals January 9, 2017 Reported February 19, 2017 as A new way Forward for Gene Therapy If you want an explanation of how mRNA works within a cell, check out the video above from the Khan Academy. Unfortunately, the speaker seems to think that sickle-cell disease is caused by a mutation. All serious scientists know that the hemoglobin S variant is a biophysically constrained nutrient energy-dependent ecological…

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George Church refutes theistic evolution (2)

February 10, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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See: George Church refutes theistic evolution George Church may not know that he refuted every aspect of theistic evolution in his presentation on February 8, 2017. Hopefully, someone will tell him how he linked quantum physics from chemistry to biophysically constrained protein folding and all biodiversity, or explain to others how he did that. Here is my explanation of his admissions. I placed the explanation into the context of this poster session submission. Title: Energy as information and constrained endogenous…

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Energy as information and constrained endogenous RNA interference (2)

February 4, 2017
James Kohl
Adaptations, Diseases & Disorders, Ecology, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Variations
2 Comments

Precision Medicine virtual conference, Feburary 22-23, 2017 This abstract has been accepted for presentation as a poster. Title: Energy as information and constrained endogenous RNA interference  James V. Kohl RNA-mediated.com jvkohl@bellsouth.net Abstract describing the poster Abstract: Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry.  Light induced energy-dependent changes link  angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing  to the physiology of reproduction…

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Base pairs, amino acids and phenotypes

November 20, 2016
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase DNA repair by homologous recombination (HR) underpins cell survival and fuels genome instability, cancer, and evolution. Autophagy is the established link from energy-dependent changes in base pairs and RNA-mediated amino acid substitutions to DNA repair in the context of polycombic ecological adaptations that prevent the hecatombic evolution of virus-driven pathology. Inventing new detailed models of DNA repair serves only to confuse those who have already…

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Polycombic ecological adaptation as a science, not a theory

October 26, 2016
James Kohl
Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Multi-omic data integration enables discovery of hidden biological regularities   Excerpt: Tracing the central dogma of biology (left column), we can link specific data types (middle column) to explain each of these biological processes. In this work, novel biological regularities that relate these processes are discovered through: (i) primary omics data (top box, right column) and (ii) integration with GEMs (bottom box, right column).   Excerpt: The approach directly addresses the BD2K grand challenge and is made conceptually accessible by…

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