polymorphism

The essence of precision medicine

The media-industrial complex attack CNN chief: Politicians should oppose Trump’s attack on media …Trump’s labeling of the media as the enemy of the state was unfortunate and dangerous. It was an accurate label that has been supported by Bill Gates and the Allen Institute in the context of the forthcoming viral apocalypse. See for comparison this enemy of the state-issued media representation:   “We are all proud of professor Filipp’s accomplishments,” Vice Chancellor for Research Samuel Traina said. “He exemplifies…

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Chirality is reality

I was banned from commenting on phys.org posts about a year ago, but recently found I could post to their FB page. This forces their “science” journalists to fight against the accurate representations of biologically-based cause and effect. Here’s an example of how they scrambled to defend their .org domain after my series of ~ 40 posts on chirality culminated with this one from January 1, 2017: Energy-dependent chirality (2) They linked light-induced changes in gamma oscillations (20-50 Hz) to…

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Sudden death indel polymorphism

An insertion/deletion polymorphism within 3’UTR of RYR2 modulates sudden unexplained death risk in Chinese populations. …different alleles of rs10692285 could alter the local structure of RYR2 mRNA and microRNA (miRNA) binding. See for comparison: Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant The differences between the 370A knockin mouse phenotypes and those of loss- and gain-of-function models emphasize the advantage of a more accurate mouse model. In this study an adaptive variant links the mouse…

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Phylogenetic similarity sans energy

Phylogenetic Similarity of Popular Rice Varieties from Different Sources (2016) Cites: Sablok and Shekhawat (2008) Excerpt: “Microsatellites, often abbreviated as simple sequence repeats (SSRs), are 1 to 5 bp repeat mutation prone motifs. Due to mutation prone specific and high rate of polymorphism, microsatellites (SSR) have become a modern genetic resource tool for the genetic mapping studies, developing and establishing new patterns of molecular breeding and in inferring the phylogenetic and comparative genome analysis. These repetitive stretches are distributed in…

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Hydrogen-atom energy in DNA base pairs

See also: Consciousness is simply food rearranged Role of Double Hydrogen Atom Transfer Reactions in Atmospheric Chemistry Abstract excerpt:  Hydrogen atom transfer (HAT) reactions are ubiquitous and play a crucial role in chemistries occurring in the atmosphere, biology, and industry. My comment: The link from physics to chemistry and the conserved molecular mechanisms of biologically-based RNA-mediated cell type differentiation has been the focus my works for more than 20 years, even before I knew what I would need to explain…

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From angstroms to ecosystems and entropy

Text with these references to follow. The two submissions should be available within the month. I will announce the availability and add the text with links to the citations at that time. From hydrogen-atom transfer in DNA base pairs to ecosystems [1] Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system [2] Ultraviolet Absorption Induces Hydrogen-Atom Transfer in G⋅C Watson–Crick DNA Base Pairs in Solution. [3] Photonic Maxwell’s Demon [4] Common origins of RNA, protein and lipid…

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Multi-omic analysis features (SNPs, miRNA)

See also: Viral and Cellular Genomes Activate Distinct DNA Damage Responses Excerpt: Central to life is the faithful replication, inheritance, and maintenance of genomic DNA. The MRE11/RAD50/NBS1 (MRN) complex andATMplay a critical role in this biological mandate (Ciccia and Elledge, 2010). Cellular double-strand breaks (DSBs) are sensed by MRN and trigger the assembly of DNA damage response (DDR) foci that amplify global ATM signaling to induce cell-cycle arrest and DNA repair (Polo and Jackson, 2011). DNA viruses are an ancient…

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What about birds?

A sex researcher who typically fails to respond to my comments and questions recently noted that: “New species are only supposed to arise when a population separates into two.” She asked: “So what’s going on with the birds on tiny Santa Cruz Island?” I would have been happy to tell her — if ever she had responded to my past comments. Instead, her question makes good cannon fodder for this blog. See: This Jay Is Evolving in a Very, Very…

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The new light of chromosomal rearrangements

SCIENCE Seeing X Chromosomes in a New Light By CARL ZIMMER JAN. 20, 2014 NY TIMES Excerpt 1: In the journal Neuron, a team of scientists has unveiled an unprecedented view of X-chromosome inactivation in the body. They found a remarkable complexity to the pattern in which the chromosomes were switched on and off. My comment: The remarkable complexity of nutrient-dependent pheromone-controlled chromosomal rearrangements that led to difference in sex chromosomes was detailed in our 1996 Hormones and Behavior review article in the section on: Genetic…

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