pre-mRNA splicing

2018 March for Science vs microRNAs

Summary: Only biologically uninformed theorists and other pseudoscientists do not seem to know that all carbon-based life is quantized energy-dependent and that biophotonic energy as information comes from the sun. It is obvious to all serious scientists that proton gradients link photons from quantized energy as information to the proton motive force, which is how the potential of hydrogen (pH) is linked to changes in the microRNA/messenger RNA balance that biophysically constrain viral latency in the context of hydrogen-atom transfer…

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An evolutionary theory killer

The eternal significance of microRNAs (3)

Summary:  RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment was not linked to sympatric speciation via The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression Something has gone horribly wrong.   I suspect the overwhelming ignorance of biologically uninformed theorists is the problem because their silence is deafening. When trapped by their ridiculous theories, they no longer kick, scream, or bite (like weasels). They participate in so-called marches like the 2018 March for…

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From Precis to Proof in 6000 years (3)

See first: Coulombic interactions facilitate polycombic adaptation See also: From Precis to Proof in 6000 years (2) See also: RNA catalyses nuclear pre-mRNA splicing 06 November 2013 Conclusion: …our data indicate that the spliceosome, like the ribosome44,45, uses RNA to effect catalysis in the context of a complex ribonucleoprotein assembly. Moreover, the common catalytic mechanism used by the spliceosome and group II introns is consistent with a common evolutionary origin between the spliceosome and these ancient RNA retroelements46,47. Our findings…

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Biophotonics, glycobiology, quantized biodiversity (2)

From Fertilization to Adult Sexual Behavior (1996) In our section on Molecular epigenetics, we wrote: Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility…

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Mystery machine vs medical intelligence

There’s a Mystery Machine That Sculpts the Human Genome Excerpt 1) This is an important milestone in understanding the three dimensional structure of chromosomes, but like most great papers, it raises more questions than it provides answers… My comment: That claim is common among researchers who need to keep being funded. Excerpt 2) “There’s a growing appreciation that some diseases are related to how the genome is oriented rather than just a mutation,” adds Rao. “This is a little speculative,…

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Alternative splicings (very technical)

From time to time I try to update my knowledge base on specific aspects included in my model. Here is the link to an open access article that may be of interest to others who want to learn more about biologically based cause and effect. This is not the type of information that you are likely to see in news reported by science journalists. Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition Excerpt 1) DNA…

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