pre-mRNA

Alternative splicings (very technical)

From time to time I try to update my knowledge base on specific aspects included in my model. Here is the link to an open access article that may be of interest to others who want to learn more about biologically based cause and effect. This is not the type of information that you are likely to see in news reported by science journalists. Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition Excerpt 1) DNA…

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Pheromones and cancer

Transcription Factor-MicroRNA-Target Gene Networks Associated with Ovarian Cancer Survival and Recurrence Excerpt: “MicroRNAs (miRNAs) are small, non-coding RNA molecules that bind to complementary sequences on target mRNA transcripts, and thus, regulate gene expression at the post-transcription stage. Transcription factors (TFs) are a different type of regulator. These proteins bind to specific DNA sequences in the promoter region, promoting or repressing transcription into mRNA, and thus, regulate genes at a pre-transcription stage [4]. TFs and miRNAs can regulate each other and…

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