pre-mRNA

From base editing to RNA editing

October 27, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, Physics, RNA editing, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Variations
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Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine “Nature conveniently provides us with cytosine deaminase enzymes that operate on DNA,” Liu tells The Scientist. The creation of quantized energy in sunlight links energy as information from electrons to ecosystems via the physiology of reproduction in all living genera. The claim that “Nature” provides us with cytosine deaminase enzymes makes it seem that the enzymes emerged and automagically evolved to become purposeful and meaningful in the context of ridiculous theories…

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Cryo-EM from atoms to ecosystems

October 6, 2017
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, RNA Directed
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Summary: I’m not going to continue repeating myself indefinitely. See: Reduced protein synthesis in schizophrenia patient-derived olfactory cells The reduced protein synthesis is a clear link from the virus-driven degradation of messenger RNA to all pathology. October 5, 2017 Lactate Metabolism in Human Lung Tumors Reported as: Study challenges long-standing concept in cancer metabolism “We were completely shocked by our findings,” said Dr. Ralph DeBerardinis, Professor at CRI, Director of CRI’s Genetic and Metabolic Disease Program, and Chief of the Division…

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Predicting who wins the 2017 Nobel Prizes (3)

October 2, 2017
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, Model Organisms, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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Summary: The unique mechanism detailed in the context of “Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression” is obviously not a unique mechanism. The mechanism exemplifies the fact that RNA-directed DNA methylation is energy-dependent and the fact that virus-driven energy theft causes the degradation of messenger RNA, which serious scientists have linked to all pathology. My failure to accurately predict who would win the 2017 Nobel Prize in Physiology or Medicine can now be placed into…

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For God and Country

Life and death via chemical effects on photosynthesis

September 26, 2017
James Kohl
Adaptations, Diseases & Disorders, Ecology, Human Brain, Model Organisms, Neuronal Plasticity, Nutrigenomics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, Variations
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Summay: “…chemosignals are a promising approach both to modeling posttraumatic stress disorders in humans [36] and to searching for mehods of their treatment.” Serious scientists linked the sense of smell in bacteria from the physiology of pheromone-controlled reproduction in all living genera to our visual perception of energy and mass in the context of the space time continuum. The fact that food odors and pheromones biophysically constrain cell type differentiation in mammals was first placed into the context of [Pheromonal…

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Pseudoscientists hate what science explains! (3)

August 17, 2017
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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See also: Pseudoscientists hate what science explains (2) Summary: In addition to germline silencing via information transfer to the physical landscape of supercoiled DNA, multicopy transgene arrays are linked from changes in the microRNA/messenger RNA balance to variation in their somatic expression level. That fact helps to establish the difference between healthy longevity and pathology across generations. Problems with DNA replication can cause epigenetic changes that may be inherited for several generations My summary: The polycomb repressive complex 2, additional…

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MicroRNAs GnRH and the failure of sex research

June 16, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Summary: “The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression” accurately represents what is known about food energy-dependent RNA-mediated cell type differentiation in species from soil microbes to humans. MicroRNAs are not new players in the hypothalamic control of fertility and the effects of food odors and pheromones on microRNAs link energy-dependent changes in hormones to behavior. That fact was detailed two decades ago in our Hormones and Behavior review. Now see: [MicroRNAs: new players…

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Food energy-dependent epigenetic adaptation (2)

May 24, 2017
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Physics, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Variations
One Comment

Due to the overwhelming support for my model of top-down causation and all energy-dependent biophysically constrained biodiversity on Earth, I will replace Food energy-dependent epigenetic adaptation (2) with the more appropriately titled God’s shrinking role in your salvation See: Food energy-dependent epigenetic adaptation and God’s shrinking role in your salvation (in prep) before proceeding to the rest of this series on epigenetic adaptation.  

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Energy-dependent epigenetic translation to mRNA stability (6)

May 22, 2017
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
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See: Energy-dependent epigenetic translation to mRNA stability (5) Five energy-dependent amino acid substitutions are linked to differences in RNA content and biodiversity in 4 mammalian species. Excerpt: Species- and tissue-specific variation in mt-tRNA incorporation into the mt-LSU was analyzed….  Analysis of porcine dermal fibroblasts (C), human osteosarcoma 143B cells (D), bovine cardiac tissue (E), and rat hepatic tissue (F) depicts the relative abundance of each mt-tRNA across fractions (ImageQuant software); represented as a percentage of the total signal. In my…

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Energy-dependent epigenetic translation to mRNA stability (5)

May 22, 2017
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA-directed DNA methylation, Variations
One Comment

Energy-dependent epigenetic translation to mRNA stability (4) From Fertilization to Adult Sexual Behavior Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…. See also: The Supraspliceosome – A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus Abstract conclusion: …changes in these regulatory processing activities are associated with human disease and cancer. These findings emphasize the supraspliceosome as…

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Respiration-dependent endogenous RNA interference

April 14, 2017
James Kohl
Adaptations, Alternative Splicings, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Variations
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If you are a theorist, please take a deep breath before beginning to read this. The speed of light on contact with water has been linked from the level of oxygen on Earth to all biodiversity via the physiology of pheromone-controlled reproduction and the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes in all living genera. @jvkohl 15h15 hours ago  It’s “game over” for all theorists. There’s a new game in town. https://www.kicktraq.com/projects/geniusgames/cytosis-a-cell-biology-board-game/ … It’s an evolutionary theory killer. @jvkohl…

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