protein evolution

Coherently organized healthy longevity (1)

A large-scale binding and functional map of human RNA-binding proteins [RBPs] 7/29/20 We describe the spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization. These data expand the catalogue of functional elements encoded in the human genome by the addition of a large set of elements that function at the RNA level by interacting with RBPs. Reported as: ENCODE consortium identifies RNA…

Read More

Nick Lane refutes theistic evolution (1)

Neo-Darwinian theorists and others who are biologically uninformed will learn this in September (2018). Synopsis: The difference in two photons has been linked to the Proton motive force. It drives the activity of the enzyme, ATP synthase, which makes ATP. All energy-dependent biophysically constrained viral latency has since been linked from the creation of ATP synthase and the creaton of ATP to changes in the microRNA/messenger RNA balance and healthy longevity. For comparison, the virus-driven degradation of messenger RNA has…

Read More

Anti-entropic sunlight: Schrödinger’s Creationist Secret? (5)

Anti-entropic sunlight: Schrödinger’s Creationist Secret? (3) The list of those scheduled to present has changed. Michael Rosbash has been added. John E. Walker is not scheduled, which suggests that everyone else already knows that the creation of the sun’s anti-entropic virucidal energy is the link from the creation of ATP to the creation of RNA and all biophysically constrained viral latency via feedback loops and the physiology of reproduction. Rosbash, as all serious scientists know,  started with energy-dependent changes in…

Read More

Observing energy-dependent intelligence and human idiocy

Conclusion: “Absolutely no information is provided about the sensory systems that enabled predators to detect their single-celled prey. No explanation is offered of how the sensory systems came into being that permitted single-celled organisms to detect their enemies’ scents and thus survive. Neither are we told what “evolutionary” mechanisms entered the equation during the construction of this extraordinarily complex mechanism.” Seeing the Beautiful Intelligence of Microbes …slime molds have evolved a system for essentially mapping their terrain and memorizing where…

Read More

Dobzhansky 1973 and precision medicine (3)

Dobzhansky 1973 and precision medicine Dobzhansky 1973 and Precision Medicine (2) How Do Bacteria Help Cancer Studying bacterial effects on cancer are very complex, because there is no one clear mechanism Jon LIeff has again obfuscated the clarity of facts about energy-dependent conserved molecular mechanisms. These are the facts: 1) Closed feedback loops link nutrient energy-dependent pheromone-controlled quorum sensing in bacteria to supercoiled DNA in all living genera. 2) Virus-driven energy theft causes the degradation of messenger RNA in bacteria…

Read More

Origin and evolution of the genetic code

Origin and evolution of the genetic code: the universal enigma Excerpt: …it appears essentially certain that the evolution of the code involved some combination of frozen accident with selection for error minimization. My comment: This claim from 2009 failed to address anything currently known to serious scientists about the Schrodinger’s claim from 1944, in What is Life? Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state…

Read More

Deeply ingrained thoughts

A universal trend of amino acid gain and loss in protein evolution Excerpt: “We cannot conceive of a global external factor that could cause, during this time, parallel evolution of amino acid compositions of proteins in 15 diverse taxa that represent all three domains of life and span a wide range of lifestyles and environments. Thus, currently, the most plausible hypothesis is that we are observing a universal, intrinsic trend that emerged before the last universal common ancestor of all…

Read More

Understanding cell type differentiation

The Wisdom of the Fly Crowds by Ed Yong Excerpt: “This is a landmark study of collective behaviour,” says Iain Couzin… “Never before has it been possible to unweave the intricate coding of social behaviour during collective decision-making.” When it comes to fruit flies, scientists…  can really start to understand the origins of collective behaviour—how genes in the fly’s neurons are activated, how those neurons process signals from the fly’s environment, and how they drive individual behaviours that, in turn,…

Read More

Thermodynamic constraints and ecological adaptations sans evolution

Relationship between protein thermodynamic constraints and variation of evolutionary rates among sites Excerpt: “…a two-variable model that combines stability and stress signi ficantly improves predictions. Therefore, both the overall stability [symbol] and the stress [symbol] seem to capture distinct thermodynamic constraints on protein evolution.” My comment: Proteins do not evolve. Nutrients are required. Metabolism of nutrients to species-specific pheromones controls the physiology of reproduction in species from microbes to man. The nutrient-dependent pheromone-controlled physiology of reproduction enables epistasis via nutrient-dependent RNA-directed DNA…

Read More