protein-folding

Complexity: Routes and Patterns (5)

May 31, 2018
James Kohl
Adaptations, Diseases & Disorders, Ecology, Light Energy, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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Summary: Complexity does not emerge.Top-down causation is energy-dependent. Geoge FR Ellis, who co-authored The Large Scale Structure of Space-Time (1973) with physicist Stephen Hawking, just refuted every aspect of neo-Darwinian pseudoscientific nonsense and Big Bang cosmology by linking the creation of the sun’s anti-entropic virucidal energy to the complex metabolic regulatory networks of cellular function. Bacterial self-organization: co-enhancement of complexification and adaptability in a dynamic environment (2003) Learning from Bacteria about Natural Information Processing (2009) Focusing on the energy, matter,…

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Light-controlled cell biology (revisited)

March 21, 2018
James Kohl
Adaptations, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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See Sci-Bay Scholar for citations and downloads of more than 3300 published works that link viruses to microRNAs Summary: …either the organized genomes of all cell types use the energy source, or viruses use the biophysically constrained energy of the cell types. No extant species can be used as an example of how the virus-driven theft of quantized energy can be linked from natural selection to the evolution of a new species. See also, with my emphasis: Light Offers New…

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Diet-driven RNA interference and cancer prevention (3)

January 18, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, Cytosis, Diseases & Disorders, Ecology, RNA Directed
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Excerpt: They claim to have found novel autoregulatory feedback loops that link changes in microRNAs to the alternative splicing factors SRSF1 and SRSF2.  Ectopic expression of SRSF1 can automagically repress the level of multiple microRNAs and SRSF2 can automagically upregulate miRNA expression. The fact that a peer-reviewed work published in 2018 links autoregulatory feedback loops to automagically altered gene expression and apoptosis via alternative splicings of pre-mRNAs suggests it is time for all serious scientists to retire. The magic of pseudoscientists has…

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Energy-dependent pheromone-controlled entropy (3)

March 15, 2017
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Light Energy, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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See: Energy-dependent pheromone-controlled entropy (2) Let’s make peer review scientific …peer review is often biased and inefficient. It is occasionally corrupt, sometimes a charade, an open temptation to plagiarists. Even with the best of intentions, how and whether peer review identifies high-quality science is unknown. It is, in short, unscientific. Here’s another failed attempt to put top-down causation back into the context of peer review. Electron transfer between anatase TiO2 and an O2 molecule directly observed by atomic force microscopy…

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George Church refutes theistic evolution (2)

February 10, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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See: George Church refutes theistic evolution George Church may not know that he refuted every aspect of theistic evolution in his presentation on February 8, 2017. Hopefully, someone will tell him how he linked quantum physics from chemistry to biophysically constrained protein folding and all biodiversity, or explain to others how he did that. Here is my explanation of his admissions. I placed the explanation into the context of this poster session submission. Title: Energy as information and constrained endogenous…

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Theories vs facts about polycombic adaptation

December 6, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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See: Demoncrats fight polycombic ecological adaptation Exosomes as miRNA Carriers: Formation–Function–Future Important aspects will be highlighted as a take-home message (THM) at the end of each paragraph. THM: Extracellular vesicles transport miRNA in a paracrine and endocrine manner. Questions regarding the cellular options of producing either microvesicles or exosomes and their difference in miRNA composition and number are still unknown. In my 2014 invited review, the four F’s, Formation–Function–Future and Copulation were included in details about how the nutrient energy-dependent…

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Epigenetics and autophagy vs mutations and evolution (5)

November 11, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA methylation, Variations
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Two-Photon Microscopy’s Historic Influence on Neuroscience Excerpt: Yuste says he’s proud of what he and Denk accomplished. “But now I go to meetings where everyone is presenting two-photon calcium imaging, and no one knows, or remembers, or cites our work,” he says, laughing. My comment: What else can be done but laugh? Most researchers still have not linked the anti-entropic energy of virucidal ultraviolet light from the biophysically constrained RNA-mediated chemistry of protein folding to all biodiversity in all genera…

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Epigenetics and autophagy vs mutations and evolution

November 10, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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RNA interfernce in “evolution” My comment: What evolved? See for comparison: Energy-dependent RNA-mediated biophysically constrained protein folding chemistry in the context of ecological adaptation.  

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From Precis to Proof in 6000 years

November 5, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, RNA Directed
One Comment

Religious texts, such as The Holy Bible appear to be like a Precis of works from God. He seems to be explaining energy-dependent creation in the context of what is currently known to serious scientists about biophysically constrained RNA-mediated protein folding chemistry, healthy longevity and RNA-mediated biodiversity. God made it perfectly clear, in advance, that all miraculous biodiversity is energy-dependent. Energy as information is the theme that extends to the weekend resurrection of the bacterial flagellum in P. fluorscens. Biologically…

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Hydrogen-atom energy in DNA base pairs

September 19, 2016
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, Variations
One Comment

See also: Consciousness is simply food rearranged Role of Double Hydrogen Atom Transfer Reactions in Atmospheric Chemistry Abstract excerpt:  Hydrogen atom transfer (HAT) reactions are ubiquitous and play a crucial role in chemistries occurring in the atmosphere, biology, and industry. My comment: The link from physics to chemistry and the conserved molecular mechanisms of biologically-based RNA-mediated cell type differentiation has been the focus my works for more than 20 years, even before I knew what I would need to explain…

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