Epigenetics II: Cellular Memory, Imprinting, and Targeting Genome Configuration With RNA Excerpt: “… germline-specific piRNA-targeted epigenetic control is key to understanding how life history events activate natural genetic engineering.” My comment: Researchers are not reporting the molecular epigenetics of RNA-mediated genetic engineering in the context of natural genetic engineering. Indeed, it sometimes seems that other … RNA-mediated genetic engineering
Physics, Chemistry, and Molecular biology (PCMb) link ecological variation to ecological adaptations via a model of gene-cell-tissue-organ-organ system complexity that I first presented in 1992. After adding gene activation by pheromones, I co-authored a book that linked the pheromone-controlled physiology of reproduction across species from microbes to man: The Scent of Eros: Mysteries of Odor … Physics, Chemistry, and Molecular biology (PCMb)
Epigenetics of Trained Innate Immunity: Documenting the epigenetic landscape of human innate immune cells reveals pathways essential for training macrophages. By Ruth Williams | September 25, 2014 [open access] Excerpt: “…they then analyzed genome-wide distributions of four epigenetic indicators of gene activity: DNAse hypersensitivity and three different histone modifications—trimethylation of histone H3 at lysine 4, … Epigenetically-effected metabolic shifts and ecological adaptations
Hypothesis & Theory ARTICLE Front. Genet. | doi: 10.3389/fgene.2014.00345 Interplay of microRNA and epigenetic regulation in the human regulatory network. Excerpt: “…a detailed model of the epigenetic interaction and its relations with the cellular environment would be required, and this is still an open issue (24).” My comment: Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Conclusion: “Minimally, … Mathematical model: microRNA and epigenetic regulation
Scientists discover an on/off switch for aging cells The switch controls the growth of telomeres, the timekeepers of cells September 19, 2014 Excerpt: Understanding how this “off” switch can be manipulated–thereby slowing down the telomere shortening process–could lead to treatments for diseases of aging (for example, regenerating vital organs later in life).” My comment: Seemingly … Seemingly futile cycles are not thermodynamically futile
Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons Directed evolution of a far-red fluorescent rhodopsin reported as: New technique uses a genetic tool and light to view and map neuronal circuits Excerpt 1): “This [directed evolution] experiment demonstrates how rapidly these remarkable bacterial proteins can evolve in response to new demands. … New technique used in report of atomic-level ecological adaptations
Heritable Histones Scientists show how roundworm daughter cells remember the histone modification patterns of their parents. By Ruth Williams | September 18, 2014 My comment: Strike three, your theories are out. Re: Strike 1) Combating Evolution to Fight Disease Strike 2) RNA and dynamic nuclear organization Strike 3) Starvation-Induced Transgenerational Inheritance of Small RNAs in … Can epigenetic inheritance occur without concurrent changes in morphology AND behavior?
Diana Maria Petrosanu asked a question in an Evolutionary Psychology News discussion about Evolution’s Random Paths Lead to One Place. I’ve been very vocal in other discussions that tout ridiculous theories that have been repeatedly refuted by biological facts. My answer to her question might help others to understand the language of RNA-mediated events. That’s … Behavior: The first response is RNA-mediated not genetically-determined
Pregnancy Stress Spans Generations The stressors a female rat experiences during pregnancy can have repercussions for her granddaughters, a study shows. By Anna Azvolinsky | August 7, 2014 Excerpt: “These changes could be the result of a microRNA (miRNA)-mediated mechanism, which may be epigenetically inherited across generations.” My comment: There is currently no alternative explanation for these changes. However, … A microRNA-mediated mechanism that is epigenetically inherited
Everything known about quantum biology “…suggests conscious experience is intrinsically connected to the fine-scale structure of space–time geometry, and that consciousness could be deeply related to the operation of the laws of the universe.” See for review: Consciousness in the universe: A review of the ‘Orch OR’ theory. These laws of the universe might lead others … The quantum biology of consciousness
