protein-folding

A “new” code enables ecological adaptation

Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity Reported as: Discovery of new code makes reprogramming of cancer cells possible Excerpt: …an unexpected new biology that provides the code, the software for turning off cancer,” says the study’s senior investigator, Panos Anastasiadis, Ph.D., chair of the Department of Cancer Biology on Mayo Clinic’s Florida campus. That code was unraveled by the discovery that adhesion proteins — the glue that keeps cells together —…

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Is life the balance between quantum and classical physics?

If life hangs in the balance between quantum and classical physics, the anti-entropic effect of the sun’s biological energy is what keeps it hanging, albeit not indefinitely. Until you consider the fact that viruses link entropic elasticity to genomic entropy in all genera, you may not realize that your life hangs in the balance between pseudoscientific nonsense about mutations and facts about the biophysically constrained nutrient-dependent RNA-mediated protein folding. Protein folding links physics and chemistry to biology via everything know…

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Anti-entropic containment of energy: symbiosis 1.0

Scientists explore the origins of energy in chemical reactions using experimental quantum chemistry Excerpt: One thing that all chemical reactions have in common—whether they are the reactions that take place inside a battery, the metabolic reactions inside a living organism, or the combustion reactions that cause an explosion—is that they all involve some kind of change in energy. My comment: Therein lies the problem with attempts by pseudosceintists to link nutrient energy from ecological variation to epigenetically-effected ecological adaptation, which…

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The “great filter” is an epigenetic trap

The great filter The silence of universe seems ominous. Was Earth lucky? Thanks to George Ellis​ for alerting others to this. Excerpt: Nick Lane in his magnificent new book The Vital Question thinks that a peculiar feature of all earthly life — that it traps energy in the form of protons pumped across membranes… Excerpt 2) Next, after a couple of billion years, creatures bigger than microbes emerged, once (Nick Lane argues) an energy-per-gene limit was breached by the invention…

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Information and communication (2)

Leaving an Imprint Among the first to discover epigenetic reprogramming during mammalian development, Wolf Reik has been studying the dynamics of the epigenome for 30 years. By Anna Azvolinsky | August 1, 2015 Excerpt: In the mammalian field, the imprinting field, together with the X-inactivation field, was the birthplace of epigenetics. My comment: Researchers like Wolf Reik never mentioned the role viruses play in preventing cell type differentiation. The birthplace of epigenetics became associated with a “still-birth.” The still-birth continued to…

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Rs3827760 is Val370Ala and EDARV370A

Introduction: A Single Nucleotide Polymorphism (SNP) is a DNA sequence variation in which a single nucleotide — A, T, C or G — in the genome (or other shared sequence) differs between members of a biological species or paired chromosomes. SNPs within a coding sequence do not necessarily change the amino acid sequence of the protein that is produced. Rs3827760 is Val370Ala Excerpt: …Val370Ala, is a SNP in the ectodysplasin A receptor EDAR gene on chromosome 2. The EDAR gene…

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Domestication via a single amino acid substitution

Evidence That the Origin of Naked Kernels During Maize Domestication Was Caused by a Single Amino Acid Substitution in tga1 Excerpt: “Our molecular and genetic analyses of tga1 show how a simple amino acid change can alter protein function and thereby drive the evolution of a new phenotypic state.” Reported as: Study shows how a kernel got naked and corn became king Excerpt: The answer often lies in mutations, the currency of evolution. Sometimes single letters are changed in the…

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Decreased phenotypic variation: Faith in Facts

Serious scientists have known for more than a decade that …phenotypic variation decreases through geologic time, because microRNAs (miRNAs) increase genic precision, by turning an imprecise number of mRNA transcripts into a more precise number of protein molecules… See for example: MicroRNAs and metazoan macroevolution: insights into canalization, complexity, and the Cambrian explosion That fact links the anti-entropic epigenetic effects of nutrient-dependent microRNAs to DNA repair in the organized genomes of species from microbes to man. Viruses appear to cause…

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RNA-mediated gene duplication, fixation, and ecological adaptation

Chromosomal Arrangement of Phosphorelay Genes Couples Sporulation and DNA Replication Excerpt: The simplicity of this coordination mechanism suggests that it may be widely applicable in a variety of gene regulatory and stress-response settings. Reported as: Bacteria use DNA replication to time key decision Excerpt: “Successful sporulation requires two complete copies of the bacterial chromosome, so coordination between the sporulation decision and the completion of DNA replication is very important,” Narula said. “A good analogy might be a semester-long course in…

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MicroRNA controlled growth and brain development

Navigable networks as Nash equilibria of navigation games Nature Communications | Article  Open Excerpt: Here we show that the ideal maximally navigable networks do share some basic structural properties with the Internet, E.coli metabolic network, English word network, US airport network, the Hungarian road network and a structural network of the human brain. Reported as: Researchers find the organization of the human brain to be nearly ideal Excerpt: “An optimal network in the brain would have the smallest number of…

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