proteins

An evolutionary theory killer

A reversible TCA cycle in a thermophile (3)

A pathway for mitotic chromosome formation The combination of nested loops distributed around a helically twisted axis plus dense chromatin packing achieves the 10,000-fold compaction of chromatin into linearly organized chromosomes that is required for accurate chromosome segregation when cells divide. The compaction of chromatin in the context of hydrophobicity is the topic of: Structural diversity of supercoiled DNA Our data provide relative comparisons of supercoiling-dependent twisted, writhed, curved, and kinked conformations and associated base exposure. Each of these structural…

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Your indifference is killing you and others

Summary: Coherence-inducing mechanisms is double-speak for mechanisms that are nutrient-dependent and pheromone-controlled. Feedback loops link odor and pheromone signaling with reproduction has been presented in double-speak as Looplessness in networks is linked to trophic coherence We are currently studying the entropy of the coherence ensemble we defined for this work. “In general, higher trophic coherence would be associated with lower entropy states, which means that if networks are more coherent than the random expectation there must indeed be some kind…

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Measuring energy vs human idiocy (social science)

Summary: The “… universal applicability for determination of various targets such as metal ions, miRNAs, DNAs and proteins…” is the key to understanding the differences in the energy-dependent assembly of cell types with fixed amino acid substitutions that link natural selection for energy-dependent changes in base pairs from atoms to ecosystems in all living genera. Richard Feynman complains about all the different units that are used to measure the single concept of Energy in this snippet  from one of his…

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Thinking about energy is not radical re-thinking

The brain: a radical rethink is needed to understand it …Optogenetics, a technique that uses genetic modification of neurons so that their electrical activity can be controlled with light pulses – can help us to explore their specific contribution to brain function. Optogenetics links the speed of light on contact with water to what is known about all energy-dependent cell type differentiation in all individuals of all living genera. Serious scientists, for example, have linked angstroms to ecosystems in all living…

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Theistic evolutionists fight back and lose (2)

For a historical perspective on the amount of ignorance theistic evolutionists and atheists have repeatedly displayed as they ignored everything known about the energy-dependent RNA-mediated de novo creation of genes, see: The heat shock response is self-regulated at both the transcriptional and posttranscriptional levels (1982) Thirty-five years later, there is another clear indication that theorists and atheists will never consider the fact that there must be an anti-entropic virucidal source of energy. See for example: HSP90 Shapes the Consequences of…

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Dobzhansky 1973 and precision medicine (4)

See: Dobzhansky 1973 and precision medicine (3) Evidence-based medicine has been hijacked: a report to David Sackett Fake news See for comparison: Sugar Gliders, Flying Squirrels, and How Evolutionists Explain Away Uncooperative Data …contradictory evidence drives evolutionists to embrace irrational just-so stories. Natural selection cannot “adapt” anything. Natural selection kills off the bad designs. It cannot influence the random mutations that must, somehow, come up with such amazing designs. This is the hard reality, but in order to rationalize the…

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Happy biophysically constrained Thanksgiving (in the USA)

Is there any other holiday in the world that celebrates biophysically constrained cell type differentiation in all living genera? The availability of amino acids and proteins in new genes is nutrient energy-dependent. The de novo creation of genes is biophysically constrained by the innate immune system and the physiology of reproduction. That fact was detailed for a general audience in Biblical Genesis. Today, all of us can be thankful that the pseudoscientific nonsense of neo-Darwinian theory was replaced earlier in…

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Polycombic ecological adaptation as a science, not a theory (2)

Evolutionary Constraints in the β-Globin Cluster: The Signature of Purifying Selection at the δ-Globin (HBD) Locus and Its Role in Developmental Gene Regulation Conclusion: … the results here presented indicate that purifying selection is driving not only HBD evolution but also its neighbor pseudogene, HBBP1. In the light of recent advances in the characterization of the β-globin cluster, we propose that the complex patterns of diversity observed in this genomic region arose from distinct functional constraints related with the intricate…

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How did the innate immune system evolve?

Sexually Antagonistic Male Signals Manipulate Germline and Soma of C. elegans Hermaphrodites Abstract excerpt: Why would a system exist that reduces the vigor of potential mates prior to mating? Addressing this question could provide insights into mechanisms and evolution of sexual conflict and reveal sensory inputs that regulate aging. Highlights excerpt: An unknown signal accelerates larval development, specifically the onset of puberty Reported as: Male chemistry primes females for reproduction—but at a cost “There is a fine balance between reproduction and…

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Epigenetic (re)programming of behavior

Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus Excerpt: Our results suggest that behavioral plasticity in animals may be regulated in an epigenetic manner via histone modification. My comment: Experimental manipulation of a single gene changed behavior. The evidence suggests all invertebrate and all vertebrate morphological and behavioral phenotypes can be linked via nutrient-dependent changes in microRNAs, adhesion proteins, and supercoiled DNA. See: The phylogenetic utility and functional constraint of microRNA flanking sequences My comment: Nutrient-dependent RNA methylation, RNA-directed…

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