protonated RNA interference

RNAi 2002 to AI 2021 (2)

December 30, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
One Comment

For more facts that link RNAi to young earth creationism and AI to pseudoscientific nonsense, see: DNA from dirt can offer new view of ancient life 7/12/21 The new study adds to a handful of others to show the power of DNA from ancient soils. No experimental evidence of biophysically constrained energy-dependent top-down creation of soil types exists that extends the dating from Biblical Genesis beyond the past 5-10,000 years. That fact places God’s Creation of energy-as-information into the context…

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microRNA-mediated cures (4)

December 9, 2021
James Kohl
RNA Directed
One Comment

The link from God’s Creation of sunlight and humidity to the ATP-dependent Creation of RNA was reported in 1964. See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” The synthesis of RNA in isolated thymus nuclei is ATP dependent. That fact has been linked to biophysically constrained viral latency across kingdoms at every level of examination by all intelligent serious scientists, since 1964. For example, start with God’s Creation…

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God’s microRNA-mediated Creation of genotypes (1)

September 8, 2021
James Kohl
Adaptations, base editing, biophotonics, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
One Comment

See first: Natural selection for adaptation (10) DNA Logic Circuits for Multiple Tumor Cells Identification Using Intracellular MicroRNA Molecular Bispecific Recognition  9/5/21 The bispecific intracellular miRNA controllable DNA circuit…easily extends to various cell type discrimination by adjusting the [energy-dependent biophysically constrained Creation of] miRNA species… When Fauci claimed it was molecularly impossible to engineer SARS-CoV-2 in the Wuhan lab, the extent of his lies became clear. The fact that he lied before Congress is now clearer. See: Learning noncoding RNA…

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Natural selection for adaptation (10)

September 7, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
One Comment

See: Ignoring light-activated microRNA biogenesis 10/16/18, and compare our section on pre-mRNAs and molecular epigenetics in: From Fertilization to Adult Sexual Behavior (1996) to MicroRNAs buffer genetic variation at specific temperatures during embryonic development 10/16/18, which was previously published sans mention of microRNAs as Temporal development of Drosophila embryos is highly robust across a wide temperature range 7/11/18 Changing the term from pre-mRNAs to microRNAs obfuscated food energy-dependent pheromone-regulated genetic processes of cause and effect, but see ~127,000 indexed publications…

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Natural selection for adaptation (9)

September 7, 2021
James Kohl
Adaptations, Diseases & Disorders, Ecology, microRNA editing, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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“Mapping the dynamic transfer functions of eukaryotic gene regulation” 8/31/21 links energy-dependent changes from angstroms to ecosystems via “Sterically confined rearrangements of SARS-CoV-2 Spike protein control cell invasion“ For review see Lynn Zechiedrich‘s group: “Structural diversity of supercoiled DNA” and the representation of God’s Creation of energy-dependent microRNA-mediated biodiversity in: See also: Chemists Know (10/6/14) Remember to start with Feynman’s claims about food energy. Stop the killing spree! Protect yourself sans synthetic mRNA vaccine-induced pathology. See also: Getting Closer to…

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MicroRNA-mediated population control (9)

August 13, 2021
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA interference, What's in the News
No Comments

See first: MicroRNA-mediated population control (8) 8/6/21 Light-activated microRNA biogenesis and peptide synthesis at the origin of life link biophysical constraints on the 2nd Law of thermodynamics  to microRNA-mediated biophysically constrained viral latency in all model organisms. Added support for the facts were published on 8/11/21. See: Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients The facts were reported as: Study finds four circulating miRNAs which could effectively inhibit SARS-CoV-2 replication…

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microRNA-mediated election cycles (7)

July 15, 2021
James Kohl
Adaptations, base editing, Diseases & Disorders, Ecology, microRNA editing, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic
One Comment

Are multi-quasiparticle interactions important in molecular ionization? 3/28/21 GWΓ [calculations] offers a unified description across all relevant energy scales. Our results suggest that the multi-QP regime corresponds to dynamical correlations, which can be described via perturbation theory. Few intelligent serious scientists understand the complexities of calculations needed to link God’s Creation of energy-as- information to biophysically constrained viral latency and healthy longevity across kingdoms. Most of them know what happens when a paradigm fails. Pseudoscientists know when they got stuck…

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microRNA-mediated replication cycles (10)

July 7, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, Subatomic, Variations
No Comments

See first: microRNA-mediated replication cycles (9) Conclusion from Guenther Witzany What is Life? 3/18/20 …new nucleotide sequences now appear to have originated from social agents such as viruses, their parasitic relatives, and related RNA networks, not from errors. A new definition of life must integrate the current empirical knowledge about interactions between cells, viruses, and RNA networks to provide a better explanatory power than the twentieth century narrative. The twentieth century narrative led to curated news reports that favored stupid…

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microRNA-mediated replication timing (5)

July 2, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
One Comment

Facts about energy-dependent microRNA-mediated biophysical constraints, which link protonated RNA interference (RNAi) to cell type differentiation across kingdoms via the physiology of reproduction and fixation of amino acid substitutions in organized genomes, are included in: pre-mRNA spatial distributions suggest that splicing can occur post-transcriptionally 6/29/21 Our results suggest a model in which transcription and splicing are largely independent, and the existence of a slow moving zone around the transcription site allows for the unification of co-transcriptional and post-transcriptional models of…

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microRNA-mediated replication timing (1)

June 17, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
2 Comments

The phylogenetic utility and functional constraint of microRNA flanking sequences links the patent for naturally occurring light-activated carbon fixation to viral latency and healthy longevity across kingdoms. The patent: RNA-Guided Human Genome Engineering was linked from functional constraints to gain-of-function research in High-Quality Overlapping Paired-End Reads for the Detection of A-to-I Editing on Small RNA WHO failed to examine the problems associated with gain-of-function research, which researchers now suggest led to the creation of SARs-CoV-2. The creation of SARs-CoV-2 can be…

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