Remdesivir

MicroRNA-mediated existential threats (1)

See: RNA-mediated silencing (10) Second request for clarification. Do any of your #patents link naturally occurring light-activated #carbon_fixation in #cyanobacteria to biophysically constrained #microRNA-mediated protein folding #chemistry & #viral_endemicity across kingdoms via https://www.kickstarter.com/projects/geniusgames/cellulose-a-plant-cell-biology-game Cellulose Happy Easter! Thomas E. Ichim and others hold patents on food energy-dependent pheromone-regulated genetic processes of microRNA-mediated protein folding chemistry and the pH-dependent physiology of reproduction. Non-disclosure would be an existential threat to the microRNA-mediated future of humanity. See parts 1-10 of the series: The microRNA-mediated…

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Defeating disease and Communism (4)

On 3/16/21, Timothy Normand Miller, in his role as the stupid atheist, @theosib2 wrote: If there were any of the typical indications of a designer in DNA, then I would consider that there must have been a designer. However, none of those can be found. Peptide synthesis at the origin of life 11/13/20 and The Amino Acid Composition of Quadruplex Binding Proteins Reveals a Shared Motif and Predicts New Potential Quadruplex Interactors 9/13/18 were linked to Properties and biological impact…

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Impeaching the God of Abraham (6)

I repeat: “The epigenetic effects of olfactory/pheromonal input calibrate and standardize molecular mechanisms for genetically predisposed receptor-mediated changes in intracellular signaling and stochastic gene expression…” Catalytic Asymmetric Synthesis of the anti‐COVID‐19 Drug Remdesivir 9/1/20 The catalytic asymmetric synthesis of the anti-COVID-19 drug Remdesivir… showed that this DyKAT is a first-order visual kinetic reaction dependent on the catalyst concentration. The unique chiral bicyclic imidazole skeleton and carbamate substituent of the catalyst are both required for the racemization process… The racemization process…

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Protonated RNA interference vs stupid theories (10)

Researchers linked the molecular mechanisms of EIDD-280, HCQ and remdesivir from God’s Creation of hydrogen to peptide synthesis at the origin of life and to viral latency via the ferret model organism. See: Oral drug blocks SARS-CoV-2 transmission 12/3/20 President Donald J. Trump did that for a general audience of non-scientists on 4/23/20. See: Medical experts rip Trump’s suggestion that sunlight, disinfectants may treat coronavirus. Our President “…touted a federal study Thursday that indicates sunlight and humidity can weaken the…

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From optoribogenetics to HelioRiboGenetics (1)

Optoribogenetic control of regulatory RNA molecules 9/24/20 “Opto” means light. “Helio” links God’s Creation of UV light to RNA-mediated protection from viruses across kingdoms via hydrogen-atom transfer in DNA base pairs in solution. Had he lived, Bruce S. McEwen probably would have received the 2020 Nobel Prize in Physiology or Medicine for linking God’s Creation of UV light and water from energy-as-information to biophysically constrained viral latency across kingdoms. McEwen et al., (1964) linked that heliocentric approach to scientific creationism…

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The microRNA-mediated future of humanity (8)

The levels of complexity linked to the microRNA-mediated future of humanity can be examined by ages 10-14+ via game-play of: Bacillus (failed project) See instead: Function of miR825 and miR825* as Negative Regulators in Bacillus cereus AR156-elicited Systemic Resistance to Botrytis cinerea in Arabidopsis thaliana 10/17/19 Peptide Players compete to link amino acids to build a peptide chain (a fancy word for a protein). Virulence Players take on the role of viruses and compete to infect a host cell in…

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The microRNA-mediated future of humanity (7)

Until recently, particle physics could not be linked to coherently organized biology by arbitrarily large energies. But KB Whaley and others have linked quantum coherence to high energy completion and President Donald J. Trump’s claims about effective coronavirus treatment with remdesivir. See also: INDY inhibition attenuates diet-induced NASH  (March 2020) Conserved molecular mechanisms link the light-activated assembly of the microRNA-RNA-peptide nanocomplex from the plasma-membrane tricarboxylate transporter INDY (I’m Not Dead Yet) to effective treatment of coronavirus pathology with remdesivir. If…

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The microRNA-mediated future of humanity (5)

Coronavirus facts from Scientific Creationists in South Korea (reported as a coronavirus tip to Business Insider on 5/1/2020) Re: “South Korea says recovered coronavirus patients who tested positive again did not relapse: Tests picked up ‘dead virus fragments’ Summary: Scientists from the so-called “Creationist Capital of the World” linked inaccurate test results to the end of the ongoing well-orchestrated coronavirus crisis. They also linked President Trump’s claims about UV light-activated microRNA biogenesis to protection from stress-linked virus-driven pathology in all…

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WHO’s ignorance: From roots to shoots (2)

WHO’s ignorance: From roots to shoots (1) Amino acid substitutions within or near the active site of the viral neuraminidase (NA) may affect influenza virus fitness. See: Neuraminidase inhibitor susceptibility and neuraminidase enzyme kinetics of human influenza A and B viruses circulating in Thailand in 2010–2015  The authors cite the World Health Organization’s Summary of neuraminidase amino acid substitutions associated with reduced inhibition by neuraminidase inhibitors” The summary is available as a pdf download. See also: Viral Factors Associated With…

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