replication stress

microRNA-mediated replication timing (4)

See first: microRNA-mediated replication timing (1) 6/17/21 microRNA-mediated replication timing (2) 6/27/21 microRNA-mediated replication timing (3) 6/29/21 Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome 1/15/21 was reported on 6/29/21 as Study provides first genome-wide evidence for functional importance of unusual DNA structures Some regions of the human genome where the DNA can fold into unusual three-dimensional structures called c (G4s) show signs that they are preserved by natural selection. The…

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The stability of organized genomes (4)

Note: Replication stress can be linked from nutrient stress or from social stress to thermodynamic cycles of protein biosynthesis and degradation. Stress induced pathologies arise in the context of virus perturbed protein folding, Healthy longevity arises in the context of nutrient-dependent RNA-mediated gene duplication and fixation of RNA-mediated amino acid substitutions in organized genomes via the physiology of reproduction. Others have now linked stress to cancer but they have not linked RNA-mediated amino acids substitutions and ecological adaptations to healthy…

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