replication

Defeating Disease and Communism (2)

On 4/23/20 former President Donald J. Trump reportedly linked God’s Creation of sunlight and humidity to the energy-dependent weakening of coronaviruses via RNA–RNA interaction between host and virus, but see Experts say there’s no medical basis for Trump’s suggestion that sunlight, disinfectants may treat coronavirus 4/24/20 Jonathan Reiner, professor of medicine at The George Washington University Hospital, said there’s no medical basis for Trump’s statements about sunlight. Reiner’s stupid claim can be placed into the context of “…a computational model…

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Defeating Disease and Communism (1)

Defeating Diseases with Energy 1/9/18 The mitochondria turn food’s hydrogen and carbon and inhaled oxygen into carbon dioxide (CO2), water and adenosine triphosphate, or ATP, which stores energy. God’s ATP-dependent Creation of RNA links protonated RNA interference to healthy longevity. See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964) The synthesis of RNA in isolated thymus nuclei is ATP dependent. For the link to RNA-mediated ecological adaptations, see:…

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Loss of energy as information (1)

Summary: Koonin claims that the theories of population geneticists have replaced what he calls the just-so stories of adaptationists with testable predictions. He claims that serious scientists should attempt to falsify the ridiculous theories touted by people like him, so that the ongoing use of ridiculous mathematical models can improve our understanding of evolution. I think Koonin may be attempting to address the concerns brought forward after another biologically uninformed science idiot claimed that my refutation of neo-Darwinian pseudoscientific nonsense…

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Cryo-EM: More than a suggestion

Cryo-EM imaging suggests how the double helix separates during replication October 23, 2017   Details in the structure not previously seen reveal how various protein subunits of the twin hexamers latch on to the double helix, via tiny loop-like structures. What are the subunits of protein? The subunits of proteins are called amino acids. I will not stop saying that cryo-EM links what is known about energy-dependent changes in the microRNA/messenger RNA balance from electrons to ecosystems via fixation of…

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Lethal virus kills 5 billion people?

Entertaining yourself to death

Summary: Food energy is required for the creation of enzymes that metabolize the food, which links the metabolism to the pheromone-controlled physiology of reproduction in species from microbes to humans via alternative splicings of pre-mRNAs, which are now called microRNAs in more than 65,000 published works. The horrid tradjedy of of yet another preventable death by suicide extends those works to preventing the cause of death of those killed by Stephen Paddock. Vegas gunman transferred $100K, set up cameras at…

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Coulombic interactions facilitate polycombic adaptation

RNA Structural Modules Control the Rate and Pathway of RNA Folding and Assembly Summary: Everything known to serious scientists about energy-dependent biophysically constrained RNA-mediated protein folding chemistry is attributed to “Nature” and evolution with no consideration for where the energy came from or where it goes when viruses use it for their replication. See also: War Games: False Flag Terrorism (2) I baited Sean Ovis, and caused him to join a discussion on “The Battlefield.“Sean Ovis regurgitated parts of my…

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Polycombic ecological adaptation as a science, not a theory (2)

Evolutionary Constraints in the β-Globin Cluster: The Signature of Purifying Selection at the δ-Globin (HBD) Locus and Its Role in Developmental Gene Regulation Conclusion: … the results here presented indicate that purifying selection is driving not only HBD evolution but also its neighbor pseudogene, HBBP1. In the light of recent advances in the characterization of the β-globin cluster, we propose that the complex patterns of diversity observed in this genomic region arose from distinct functional constraints related with the intricate…

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RNA methylation, learning, memory and behavior,

Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice    Excerpt: Our findings suggest that m6A is regulated in an activity-dependent manner in the adult brain, and may function to fine-tune mRNA turnover during memory-related processes.   My comment: They cite: Alarcón CR, Lee H, Goodarzi H, Halberg N, Tavazoie SF (2015) N6-methyladenosine marks primary microRNAs for processing. Nature 519:482–485.   In the context of experience-dependent learning and memory, the authors link quantized energy…

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Olfaction & the octopus and human genomes (2)

Darwinian evolution in the light of genomics Eugene Koonin excerpt: The distribution of evolutionary rates across sets of orthologous genes, the distribution of the sizes of paralogous gene families, the negative correlation between the expression level and the sequence evolution rate of a gene, and other relationships between key evolutionary and phenomic variables seem to be genuine universals of evolution. The simplicity of these universal regularities suggests that they are shaped by equally simple, fundamental evolutionary processes, rather than by…

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Faithfully repaired DNA

Origin and Evolution of DNA and DNA Replication Machineries Excerpt: …DNA replaced RNA as genetic material because it is more stable and can be repaired more faithfully.4 My comment: RNA-mediated amino acid-dependent DNA repair is nutrient-dependent. That fact need not be taken “on faith.” Without DNA repair, ecological variation could not be linked to ecological adaptations in all genera — except via the ridiculous theories invented by population geneticists. See also: The traits that make human beings unique Excerpt: That our…

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