reproduction

The origin of information (5,4,3,2,1)

May 21, 2018
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Human Brain, Light Energy, microRNA editing, Model Organisms, Physics, RNA Directed, RNA-directed DNA methylation, Subatomic
No Comments

Summary: These findings reveal a new GLU biosynthetic pathway, which could contribute to some of the sunlight-induced neurobehavioral changes. The claims about new biosynthetic pathways should be placed into the context of what is known about the energy-dependent origin of all pathways. Researchers may have solved origin-of-life conundrum …the conditions that produce nucleic acid precursors also create the starting materials needed to make natural amino acids and lipids. That suggests a single set of [light activated] reactions could have given…

Read More
An evolutionary theory killer

A reversible TCA cycle in a thermophile (3)

February 9, 2018
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
One Comment

A pathway for mitotic chromosome formation The combination of nested loops distributed around a helically twisted axis plus dense chromatin packing achieves the 10,000-fold compaction of chromatin into linearly organized chromosomes that is required for accurate chromosome segregation when cells divide. The compaction of chromatin in the context of hydrophobicity is the topic of: Structural diversity of supercoiled DNA Our data provide relative comparisons of supercoiling-dependent twisted, writhed, curved, and kinked conformations and associated base exposure. Each of these structural…

Read More
For God and Country

Kinetically Stable Thermodynamically Activated Cell Metabolism (7)

December 26, 2017
James Kohl
RNA Directed
No Comments

Summary: Why is anyone enrolled in a Ph.D program at CU Boulder’s Environmental Studies Program not aware of the facts of life presented in Schrodinger’s “What is Life? (1944) and during a virtual conference on Precision Medicine as Energy as information and constrained endogenous RNA interference See for example: Aridity weakens population-level effects of multiple species interactions on Hibiscus meyeri Reported as: A classic Darwinian ecological hypothesis holds up—with a twist December 25, 2017 Darwin and others have said that…

Read More

The overwhelming ignorance of sex researchers (2)

December 13, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, Variations
No Comments

Conclusion: There is a clear link from Estrogen receptor α polymorphism in individuals and in species with differences in behavioral phenotypes. The differences are food energy-dependent and RNA-mediated. The differences link the sense of smell and the pheromone-controlled physiology of reproduction in soil bacteria from The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression to the report on the Obligatory role of hypothalamic neuroestradiol during the estrogen-induced LH surge in female ovariectomized rhesus monkeys Reported…

Read More

Light-activated error-free DNA repair (4)

November 21, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Diseases & Disorders, Ecology, microRNA editing, RNA Directed, RNA editing
No Comments

Summary: Most of what you probably thought was about science is based on the pseudoscientific nonsense touted by biologically uninformed theorists. Attempts to mine data from any peer-reviewed article that has been published by a theorist should start with the first article that linked energy-dependent life to the creation of uranium isotopes. See: PLOS & The Hacker Within: mining scientific articles tutorial & hackathon See for comparison: microRNA See: Biogenic non-crystalline U(IV) revealed as major component in uranium ore deposits…

Read More

From base editing to RNA editing (5)

November 1, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Nutrigenomics, RNA Directed, RNA editing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
No Comments

1) Maturity’ molecule helps adolescent brain grow up   2) Geneticists are starting to unravel evolution’s role in mental illness: Hints emerge that past environments could have influenced psychiatric disorders   Please try to link the maturity molecule to the evolution of mental illness outside the context of food energy-dependent base editing, RNA editing, RNA-mediated amino acid substitutions and the pheromone-controlled physiology of reproduction that stabilizes the organized genomes of all living genera via chromosomal rearrangements.   Then see:Oppositional COMT…

Read More

The next reformation: 500 years too late? (3)

October 31, 2017
James Kohl
Adaptations, base editing, Ecology, RNA editing
One Comment

Historical perspective: October 31, 1517 was the first Reformation Day At the October 24, 2017 premiere of “Light Unshackled” (in Morganton, Georgia), I learned how the dramatic history of “The Reformation” was linked from the unnecessary suffering and premature death of many people to the life’s works of John Calvin, the leading French Protestant Reformer. Phillip Mills, Phillip Mills, Jr. and others helped me realize that John Calvin’s works led to an attempt by the Templeton Foundation to bastardize what…

Read More

From base editing to RNA editing (2)

October 27, 2017
James Kohl
Adaptations, base editing, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, RNA Directed, RNA editing, RNA-mediated epigenetic regulation of gene expression, Variations
No Comments

Summary: The link from the creation of the sun’s anti-entropic virucidal energy and the physiology of pheromone-controlled reproduction to fixation of RNA-mediated amino acid substitutions in the organized genomes of all living genera is all that is required to claim adaptation for comparison to Koonin’s moronic assertion that the amino acid composition of proteins varies because the composition evolved. Digital reconstruction of the Ceprano calvarium (Italy), and implications for its interpretation A “fresh” (i.e., not yet “fossil”) bone can be…

Read More
For God and Country

Energy-dependent structure and function: Until death (5)

October 12, 2017
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression
No Comments

Summary: If a player starts with evolution instead of the creation of energy that links ATP to the creation of RNA, the player is a loser. Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull Secular: Ancient Viruses Are Buried in Your DNA (2017) by…

Read More
For God and Country

Life and death via chemical effects on photosynthesis

September 26, 2017
James Kohl
Adaptations, Diseases & Disorders, Ecology, Human Brain, Model Organisms, Neuronal Plasticity, Nutrigenomics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, Variations
No Comments

Summay: “…chemosignals are a promising approach both to modeling posttraumatic stress disorders in humans [36] and to searching for mehods of their treatment.” Serious scientists linked the sense of smell in bacteria from the physiology of pheromone-controlled reproduction in all living genera to our visual perception of energy and mass in the context of the space time continuum. The fact that food odors and pheromones biophysically constrain cell type differentiation in mammals was first placed into the context of [Pheromonal…

Read More
RSS Perfuming the Mind