reproduction

microRNA-mediated biodiversity (9)

February 20, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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microRNA (miR-KT-635) encoded by Cyprinid herpesvirus 2 regulates the viral replication with targeting to the ORF23 (2/19/22) has been linked to the patented cure for all virus-driven diseases across kingdoms via Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency (2/8/22) Who, besides our NIH Director, Lawrence A. Tabak and former President Trump is not surprised to see that researchers from Harvard collaborated with researchers from China to obfuscate the facts from the patent for…

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microRNA-mediated biodiversity (2)

February 3, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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From microRNA-mediated biodiversity (1) See for comparison my blog posts that mention: glycine, which start with Epigenetic regulation of aging by glycine and GnRH 5/26/15 The focus here is on vertebrates, but the conserved molecular mechanisms extend across all species. Who else is watching science journalist John Hewitt continue on his collision course with reality? In Myelin is a gift from retroviruses 2/1/22, he again fails to link light-activated carbon fixation in cyanobacteria to biophysically constrained naturally attenuated viral endemicity…

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The origin of information (5,4,3,2,1)

May 21, 2018
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Human Brain, Light Energy, microRNA editing, Model Organisms, Physics, RNA Directed, RNA-directed DNA methylation, Subatomic
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Summary: These findings reveal a new GLU biosynthetic pathway, which could contribute to some of the sunlight-induced neurobehavioral changes. The claims about new biosynthetic pathways should be placed into the context of what is known about the energy-dependent origin of all pathways. Researchers may have solved origin-of-life conundrum …the conditions that produce nucleic acid precursors also create the starting materials needed to make natural amino acids and lipids. That suggests a single set of [light activated] reactions could have given…

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An evolutionary theory killer

A reversible TCA cycle in a thermophile (3)

February 9, 2018
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
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A pathway for mitotic chromosome formation The combination of nested loops distributed around a helically twisted axis plus dense chromatin packing achieves the 10,000-fold compaction of chromatin into linearly organized chromosomes that is required for accurate chromosome segregation when cells divide. The compaction of chromatin in the context of hydrophobicity is the topic of: Structural diversity of supercoiled DNA Our data provide relative comparisons of supercoiling-dependent twisted, writhed, curved, and kinked conformations and associated base exposure. Each of these structural…

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For God and Country

Kinetically Stable Thermodynamically Activated Cell Metabolism (7)

December 26, 2017
James Kohl
RNA Directed
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Summary: Why is anyone enrolled in a Ph.D program at CU Boulder’s Environmental Studies Program not aware of the facts of life presented in Schrodinger’s “What is Life? (1944) and during a virtual conference on Precision Medicine as Energy as information and constrained endogenous RNA interference See for example: Aridity weakens population-level effects of multiple species interactions on Hibiscus meyeri Reported as: A classic Darwinian ecological hypothesis holds up—with a twist December 25, 2017 Darwin and others have said that…

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The overwhelming ignorance of sex researchers (2)

December 13, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, Variations
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Conclusion: There is a clear link from Estrogen receptor α polymorphism in individuals and in species with differences in behavioral phenotypes. The differences are food energy-dependent and RNA-mediated. The differences link the sense of smell and the pheromone-controlled physiology of reproduction in soil bacteria from The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression to the report on the Obligatory role of hypothalamic neuroestradiol during the estrogen-induced LH surge in female ovariectomized rhesus monkeys Reported…

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Light-activated error-free DNA repair (4)

November 21, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Diseases & Disorders, Ecology, microRNA editing, RNA Directed, RNA editing
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Summary: Most of what you probably thought was about science is based on the pseudoscientific nonsense touted by biologically uninformed theorists. Attempts to mine data from any peer-reviewed article that has been published by a theorist should start with the first article that linked energy-dependent life to the creation of uranium isotopes. See: PLOS & The Hacker Within: mining scientific articles tutorial & hackathon See for comparison: microRNA See: Biogenic non-crystalline U(IV) revealed as major component in uranium ore deposits…

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From base editing to RNA editing (5)

November 1, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Nutrigenomics, RNA Directed, RNA editing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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1) Maturity’ molecule helps adolescent brain grow up   2) Geneticists are starting to unravel evolution’s role in mental illness: Hints emerge that past environments could have influenced psychiatric disorders   Please try to link the maturity molecule to the evolution of mental illness outside the context of food energy-dependent base editing, RNA editing, RNA-mediated amino acid substitutions and the pheromone-controlled physiology of reproduction that stabilizes the organized genomes of all living genera via chromosomal rearrangements.   Then see:Oppositional COMT…

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The next reformation: 500 years too late? (3)

October 31, 2017
James Kohl
Adaptations, base editing, Ecology, RNA editing
One Comment

Historical perspective: October 31, 1517 was the first Reformation Day At the October 24, 2017 premiere of “Light Unshackled” (in Morganton, Georgia), I learned how the dramatic history of “The Reformation” was linked from the unnecessary suffering and premature death of many people to the life’s works of John Calvin, the leading French Protestant Reformer. Phillip Mills, Phillip Mills, Jr. and others helped me realize that John Calvin’s works led to an attempt by the Templeton Foundation to bastardize what…

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From base editing to RNA editing (2)

October 27, 2017
James Kohl
Adaptations, base editing, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, RNA Directed, RNA editing, RNA-mediated epigenetic regulation of gene expression, Variations
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Summary: The link from the creation of the sun’s anti-entropic virucidal energy and the physiology of pheromone-controlled reproduction to fixation of RNA-mediated amino acid substitutions in the organized genomes of all living genera is all that is required to claim adaptation for comparison to Koonin’s moronic assertion that the amino acid composition of proteins varies because the composition evolved. Digital reconstruction of the Ceprano calvarium (Italy), and implications for its interpretation A “fresh” (i.e., not yet “fossil”) bone can be…

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