RNA-directed DNA methylation

Amino acids and virus penetration

For an example of the ocean of information you must swim through to get to an important fact about virus-driven energy theft and all pathology, see: The bacteriophage ϕ29 tail possesses a pore-forming loop for cell membrane penetration (June 15, 2016) They cite “PrDOS: prediction of disordered protein regions from amino acid sequence” (2007). Excerpt: We have also developed a system to predict disordered regions from the amino acid sequence. Our system is composed of two predictors, that is, a…

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RNA methylation, behavior, and disease

Epigenetics and Genetics of Viral Latency by Paul M. Lieberman (May 11, 2016)   My comment: Lieberman succinctly confirmed the fact that …viral latency is responsible for life-long pathogenesis and mortality risk… His simplistic conclusion also attests to the fact that there is no defined boundary between epigenetics and genetics. Epigenetic effects on metabolic networks must be linked to genetic networks via the energy-dependent innate immune system. That’s how all serious scientists knew they would need to link angstroms to ecosystems…

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Energy-dependent RNA methylation (7)

“…viral latency is responsible for life-long pathogenesis and mortality risk…” – Lieberman (2016) My comment: Energy-dependent RNA-mediated amino acid substitutions are responsible for life-long healthy longevity and decreased mortality risk. See for comparison: How cancer was created by evolution Excerpt 1) But even though it is evolutionary processes that have made cancer such a problem, it is also evolutionary thinking that is now leading to pioneering treatments that could stack the odds against cancer and in favour of our health.…

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Energy-dependent RNA methylation (1)

“How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?” — Roger Penrose “We know, for instance, when we eat food nucleic acids can get into our cells. Also, there is a theory that our cells in the body keep sending out nucleic acids and one theory has it that it seems to correct the mistakes that other cells have suffered…

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Thermotolerance and longevity (2)

See also: Thermotolerance and Longevity This article is part of the Research Topic Brain nutrient sensing in the control of energy balance: new insights and perspectives Excerpt: It is well established that nutrients act as signaling molecules in synergy with nervous and hormonal signals to inform the brain about the nutritional status of the body. The integration of these signals within the hypothalamus and other brain regions triggers behavioral and physiological responses through efferent autonomic nerves, hypothalamic-pituitary-Adrenal and thyroid axis…

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MicroRNAs and/or QTLs: Who buried what?

Making precision medicine a reality: Genomics researchers unveil road map to disease origin Excerpt: This study highlights the significance of mechanistic similarities for uncovering additional interacting downstream effectors of intergenic SNPs… My comment: Use of the term QTL may limit the understanding of how energy-dependent cell type differentiation occurs and how virus-driven energy theft is linked to all pathology. It would be great if someone would explain the difference between what QTLs do and what microRNA flanking sequences  do in…

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From nothing to life and death everywhere

Astronomers in South Africa discover mysterious alignment of black holes Excerpt 1) This implies that there is a coherent spin in the structure of this volume of space that was formed from the primordial mass fluctuations that seeded the creation of the large-scale structure of the universe. Excerpt 2) “This is not obviously expected based on our current understanding of cosmology. It’s a bizarre finding.” Excerpt 3) A large-scale spin distribution has never been predicted by theories – and an…

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Molecular Diagnostics: What is unprotected life (4)

Pado, a fluorescent protein with proton channel activity can optically monitor membrane potential, intracellular pH, and map gap junctions Excerpt: Nature has developed a vast array of voltage-responsive proteins. To improve our ability to optimize the voltage sensitivity, kinetics, and signal size of GEVIs, an in silico search strategy was developed to identify potential voltage-sensing proteins since new genomes are routinely being sequenced. The use of a conserved amino acid motif in the second transmembrane segment of the voltage-sensing phosphatase…

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Molecular Diagnostics: What is unprotected life? (2)

See also: Molecular Diagnostics: What is unprotected life? What is life when it is not protected from virus driven entropy Published on 30 Mar 2016. Presentated at Molecular Diagnostics on April 6 and 7, 2016 The poster also is available at Figshare POSTER (abstract) “The anti-entropic force of virucidal ultraviolet (UV) light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from…

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Virus-driven sex differences?

DNA methylation on N6-adenine in mammalian embryonic stem cells Excerpt: DNA methylation is a crucial component of epigenetic regulation that controls many important aspects of mammalian biology, such as imprinting, X chromosome inactivation and tumorigenesis1, 2. My comment: Nutrient-dependent RNA-directed DNA methylation links RNA-mediated amino acid substitutions to protein folding chemistry during thermodynamic cycles of energy dependent protein biosynthesis and degradation. Sex of a baby? Ancient virus makes the call Excerpt: …in other organisms, such as C elegans and the…

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