RNA-directed DNA methylation

A two-faced protein enables RNA-mediated DNA repair (5)

The title of the article below about “gut bugs” attests to the fact that the popularity of neo-Darwinism is based on the lack of popularity for any alternative. For example, Schrodinger (1944) claimed: …in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded…

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Life and death predicted by DNA methylation

The bounce rate here has more than doubled  (from 20% to 44%) during the past week at the same reports continue to support all the claims I have made about RNA-mediated cell type differentiation. Obviously, pseudoscientists are not willing to examine any evidence of biologically-based cause and effect that refutes their ridiculous claims about mutations and evolution. For comparison, serious scientists will want to read this: See: DNA methylation age is associated with mortality in a longitudinal Danish twin study…

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Behavioral Immune System model

Was the dawn of man among trees in the cradle of disease? Reported on July 4, 2013 Excerpt (with my emphasis): The impact of a forest home on the social structure of the first homo sapiens will be examined by the Division’s Dr Peter Walsh, who researches social networks in primate ecology. A major theme of the conference will be what’s known as Behavioural Immune System hypothesis – the idea that social behavior is an intrinsic part of the immune…

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Theorists can’t understand biology

See also: Neuroplasticity Thanks to Teresa Binstock for calling my attention to this:   Thanks to Anna Di Cosmo for calling the attention of others to this: My comment: Attempts to explain the “binding problem” of integration in the context of ecoimmunology and disease ecology compared to emergence and evolution are examples of how much pseudoscientific nonsense has been accepted and touted in the context of the neo-Darwinian “Modern Synthesis.” For comparison, serious scientists have detailed a model of top-down…

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Neuroplasticity

Can You Think Yourself Into a Different Person? Excerpt 1) Those who over-evangelise emerging disciplines like neuroplasticity or epigenetics can sometimes be guilty of talking as if the influence of our genes no longer matters. Excerpt 2) Of course, it’s our malleable brains that have moulded themselves to these rhythms. See also: Nature and nurture: Human brains evolved to be more responsive to environmental influences See for comparison: Mae-Wan Ho: No Boundary Really Between Genetic and Epigenetic My comment: Everything…

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Nutrient-dependent RNA-directed DNA methylation

Pattern recognition Establishing, maintaining and modifying DNA methylation patterns in plants and animals Excerpt: FIGURE 2 | Model for RNA-directed DNA methylation. Download high-resolution Power Point slide (112 KB) Where did this pattern come from? It is clearly a consideration in the context of Sensory feedback shapes individuality to provide equal space for behavioral excellence and in Feedback loops link odor and pheromone signaling with reproduction. The pattern went missing in this report: Algal ancestor of land plants was preadapted…

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Is SUMOylation RNA-directed DNA methylation? (revisited)

See: Is SUMOylation RNA-directed DNA methylation? posted here on 6/16/15 See also: 1) The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3 (subscription required 6/17/15) 2) SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3 (open access 6/23/15) 3) The CPEB3 Protein Is a Functional Prion that Interacts with the Actin Cytoskeleton (open access 6/23/15) 4) MicroRNA-22 Gates Long-Term Heterosynaptic Plasticity in Aplysia through Presynaptic Regulation of CPEB and Downstream…

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Is SUMOylation RNA-directed DNA methylation?

System-wide identification of wild-type SUMO-2 conjugation sites Excerpt: SUMOylated proteins were found to be predominantly nuclear, and involved in chromatin remodelling, RNA splicing, transcription and DNA repair. When compared with other SUMOylation studies, a significant overlap with PRISM-identified SUMO sites (48%) and SUMO target proteins (85%) was confirmed. We discovered one-fifth of the PRISM-identified SUMOylated lysines to overlap with ubiquitylation and acetylation. My comment: SUMOylation appears to be a new name for RNA-directed DNA methylation, which links nutrient-dependent RNA-mediated amino…

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RNA directed DNA methylation and cell types

Cell type differentiation is included in all topics in biology, which is why it is important to understand what is currently known about top-down causation in the context of physics and chemistry. Taken together, physics, chemistry, and the conserved molecular mechanisms of biology link Drosophila to Octopuses and all other species on this planet via RNA-directed DNA methylation and RNA-mediated amino acid substitutions that differentiate cell types. See for examples: Let there be anti-entropic light (1) An antagonist led me…

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Understanding physical forces of ecological variation and adaptation

Discovery of new subatomic particle, type of meson, to ‘transform’ understanding of fundamental force of nature   Excerpt: “Because the Ds3*(2860)ˉ particle contains a heavy charm quark it is easier for theorists to calculate its properties. And because it has spin 3, there can be no ambiguity about what the particle is,” adds Professor Gershon. “Therefore it provides a benchmark for future theoretical calculations. Improvements in these calculations will transform our understanding of how nuclei are bound together.” My comment:…

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