RNA-directed

Evolution outside the context of “the light of evolution” (2)

September 13, 2017
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Variations
One Comment

See first: Evolution outside the context of “the light of evolution” How many proponents of Intelligent Design never learned that Darwinian evolution was based on his “conditions of life?” ch 4 IV. Natural Selection; or the Survival of the Fittest  “IF under changing conditions of life…” ch 5 http://www.bartleby.com/11/5002.html “…the greater variability of species having wider ranges than of those with restricted ranges, lead to the conclusion that variability is generally related to the conditions of life…” “…we cannot tell…

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The Origin of Information (3)

August 3, 2017
James Kohl
Adaptations, Cytosis, Ecology, Model Organisms, Nutrigenomics, RNA Directed, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Variations
One Comment

Summary: I presented two poster sessions during the Labroots virtual conference “Neuroscience,” March 16-17, 2016 One linked sunlight to energy as the origin of information. The other linked energy as information to biophysically constrained viral latency via the pheromone-controlled physiology of reproduction in all living genera. Additional experimental evidence of top-down causation has since confirmed that the creation of sunlight can be linked from energy as information to all biodiversity via its anti-entropic virucidal effects. The direct quantitative measurement of…

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Theories vs facts about polycombic adaptation

December 6, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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See: Demoncrats fight polycombic ecological adaptation Exosomes as miRNA Carriers: Formation–Function–Future Important aspects will be highlighted as a take-home message (THM) at the end of each paragraph. THM: Extracellular vesicles transport miRNA in a paracrine and endocrine manner. Questions regarding the cellular options of producing either microvesicles or exosomes and their difference in miRNA composition and number are still unknown. In my 2014 invited review, the four F’s, Formation–Function–Future and Copulation were included in details about how the nutrient energy-dependent…

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RNA-mediated physics, chemistry, and molecular epigenetics (3)

May 9, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Microtargeting cancer metabolism: opening new therapeutic windows based on lipid metabolism reported as: Using microRNAs to target cancer cells By Dawn Hayward Conclusion:  MicroRNAs stand out from conventional gene-therapy-based approaches and have a niche in lipid metabolism. They can be designed specifically to target a gene and serve as modulators rather than on/off switches. Increased lipid formation and breakdown in cancer cells creates vulnerability that might be taken advantage of by microRNAs. In addition, cancer as a whole involves a…

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Confusing effects and affects of visual input

March 24, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Their report indicates that these researchers never learned to differentiate between epigenetic effects on RNA-mediated cell type differentiation compared to the experience-dependent affects on behavior of amino acid substitutions. Experience Affects Critical Period Plasticity in the Visual Cortex through an Epigenetic Regulation of Histone Post-Translational Modifications Excerpt: We show that the early exposure of rat pups to enriching environmental conditions accelerates the critical period for plasticity in the primary visual cortex, linking this effect to increased histone acetylation, specifically at…

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Energy-dependent purpose vs teleophobic telorexia

March 14, 2016
James Kohl
Adaptations, Ecology, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
No Comments

I’m not getting any responses to an attempt to discuss  On epigenetics: We are not just our DNA. That suggests I should use the claims and my attempt to discuss them in a blog post. If no one else wants to discuss the links from atoms to ecosystems in the diagram above, at least there will be a record to show they ignored them, again. James V. Kohl March 11, 2016 at 9:55 am Thanks for reporting on the symposium…

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RNA-mediated theory killers (4)

December 19, 2015
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer Excerpt: At this moment, DNA methylation and non-coding RNA including with microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) represent the largest body of available literature on epigenetic biomarkers with the highest potential for cancer diagnosis. My comment: The SLC19A3 microRNA was mentioned in the context of cancer and brain development in The impact of new technologies on clinical decision-making in health care. The location of the base…

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Life and death predicted by DNA methylation

November 28, 2015
James Kohl
Adaptations, Ecology, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
No Comments

The bounce rate here has more than doubled  (from 20% to 44%) during the past week at the same reports continue to support all the claims I have made about RNA-mediated cell type differentiation. Obviously, pseudoscientists are not willing to examine any evidence of biologically-based cause and effect that refutes their ridiculous claims about mutations and evolution. For comparison, serious scientists will want to read this: See: DNA methylation age is associated with mortality in a longitudinal Danish twin study…

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Theorists can’t understand biology

November 19, 2015
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Variations
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See also: Neuroplasticity Thanks to Teresa Binstock for calling my attention to this:   Thanks to Anna Di Cosmo for calling the attention of others to this: My comment: Attempts to explain the “binding problem” of integration in the context of ecoimmunology and disease ecology compared to emergence and evolution are examples of how much pseudoscientific nonsense has been accepted and touted in the context of the neo-Darwinian “Modern Synthesis.” For comparison, serious scientists have detailed a model of top-down…

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Receptor methylation controls behavior

November 15, 2015
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Variations
No Comments

The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling Excerpt 1) The addition of a methyl group to an arginine residue can remove a hydrogen bond donor and decrease the electrostatic surface potential at the residue, resulting in a change in size and hydrophobicity that can affect its interaction with binding partners (21). Excerpt 2) Together, these results led us to propose that arginine methylation promotes D2-like dopamine receptor signaling and that this mechanism of receptor regulation is conserved…

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