RNA-guided

An evolutionary theory killer

A single base change refutes theistic evolution (2)

Announcing publication of a model that links the creation of quantized energy from changes in subatomic particles to biophysically constrained viral latency and sympatric speciation in all living genera. Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems This angstroms to ecosystems model of ecological adaptation links nutrient energy-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA/messenger RNA balance and chromosomal rearrangements via the physiology of reproduction in species from microbes to humans. The…

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Energy as information and constrained endogenous RNA interference (4)

Premise: Sunlight is the energy as information that is required to link endogenous RNA interference to healthy longevity Counter claim:  The Quantum Thermodynamics Revolution: Information theory Understanding entropy as a subjective measure allows the universe as a whole to evolve without ever losing information. Precision Medicine virtual conference, Feburary 22-23, 2017 Title: Energy as information and constrained endogenous RNA interference  James V. Kohl RNA-mediated.com jvkohl@bellsouth.net Abstract describing the poster   Narrative: The term microRNA has been used in 58,000 indexed…

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Energy is information. Objections over ruled. You’re fired!

Objection: In the law of the United States of America, an objection is a formal protest raised in court during a trial to disallow a witness’s testimony or other evidence which would be in violation of the rules of evidence or other procedural law. Americanism (ideology) links the laws of United States of America to God’s “Laws of Biology.”  Pseudoscientists violated the rules of evidence that link Darwin’s “conditions of life” from God’s “Laws of Biology” to all nutrient energy-dependent…

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Happy Darwin Day (2017)

My series of blog posts about the refutation of theistic evolution by George Church led him to contact me via email. He asked why he would get credit for or against the refutations He claimed he was trained in quantum physics. He claimed that he has authored peer reviewed papers on protein folding, biodiversity, supercoiling, etc. He wanted to know more but did not know enough about my target audience to realize why I included information about the viral hecatomb.…

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Anthetical conclusions (2)

From Fertilization to Adult Sexual Behavior (1996) …ribosomal proteins S4X and S4Y (rpS4X, rpS4Y) are produced by sexually dimorphic genes whose protein products are sexually dimorphic. This suggests the possibility of subtle nuances in the ribosomal translation of at least some mRNA, in certain cell types (Fisher et al.,1990; Zinn et al., 1994). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster…

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RNAi: From magic bullet to billion dollar baby

UW-Madison technology enlisted in battle against hepatitis B DNA operates through RNA, and when RNA interference was discovered in 1998, it seemed like a magic bullet that could fight disease by specifically shutting down problematic genes. Before RNA interference was discovered pre-mRNAs were already linked to cell type differentiation in species from microbes to mammals. From Fertilization to Adult Sexual Behavior (1996) Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to…

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The tipping point? 50,000 publications (5)

For review see my blog posts “The tipping point? 50,000 publications” with follow-ups: (2) (3) & (4). There are now more than 52,000 published works that link microRNAs to cell type differentiation in the context of healthy longevity or virus-driven energy theft, which has been linked from viral latency to all pathology. At the rate of ~1000 more publications per month that link energy-dependent changes in the microRNA/messenger RNA balance to healthy longevity or link virus-driven energy theft to all…

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Did “Nature” kill Steve Jobs? (3)

So Many Research Scientists, So Few Openings as Professors Excerpt: Even someone as brilliant as Emmanuelle Charpentier, who in 2015 became head of the Max Planck Institute for Infection Biology after a momentous discovery in gene editing, spent the previous 25 years moving through nine institutions in five countries. My comment: Why did she move around so much when in the same year, on 07/02/2015, George Church and colleagues filed a patent application for “RNA-Guided Human Genome Engineering.” Excerpt: Repetitive…

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Funding the Human Genome Project-Write

The Genome Project-Write Excerpt: …understanding of genetic blueprints could come from construction of large, gigabase (Gb)-sized animal and plant genomes, including the human genome, which would, in turn, drive development of tools and methods to facilitate large-scale synthesis and editing of genomes. To this end, we propose the Human Genome Project-Write (HGP-write), named to honor HGP-read but embracing synthesis of all large genomes. My comment: Synthesis is nutrient energy-dependent and the synthesis of all large genomes links the innate immune…

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RNA-guided gene editing

From June 14, 2015 Light induced RNA-mediated gene activation Eye-independent, light-activated chromatophore expansion (LACE) and expression of phototransduction genes in the skin of Octopus bimaculoides Energy-dependent RNA-mediated prevention of heart failure Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure Theoretical pseudoscientific nonsense Ancient DNA reveals how Europeans developed light skin and lactose tolerance Energy dependent RNA-mediated brain development Scientists find genetic underpinnings of functional brain networks seen in imaging studies More pseudoscientific nonsense Scientists show future events…

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