RNA-Mediated

Why Don’t The Amish Get Cancer? …the Amish commitment to simple, productive lives and clean, local food is benefiting their health in ways that the rest of America can only dream about. They exemplify what it means to be an ecologically adapted human population. See also: Past 5,000 years prolific for changes to human genome The facts support the beliefs of young earth creationists. That invites ridicule and denigration of my published works. But the experimental evidence of biologically-based cause and…

Critical values expose virus-driven energy theft

January 7, 2017

Adaptations, Autophagy, biophotonics, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA–Mediated Epigenetic Heredity, Variations

Critical Values: is ASCP’s quarterly magazine with news and features covering trends of interest to pathologists and laboratory professionals alike. See for example: Attentive Clinical Laboratory Scientist Discovers First Human Case of Borrelia turicatae Critical Values spoke with technologist Dolli Lane, MLT(ASCP)CMCsCM, and the chief of the hematology section, Chris Boyd, MLT(ASCP)CM, about their findings. Their story demonstrates how attention to detail saves lives. Every serious scientist I know is on the verge of linking the creation of the sun’s…

Energy-dependent chirality

January 1, 2017

Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations

See also: Achiral glycine Summary: Virus-driven energy theft alters the interactions between physics and chemistry that maintain biophysically constrained biodiversity. That’s how viruses are linked from mutations to all pathology. Nutrient energy-dependent changes in the context of the pheromone-controlled physiology of reproduction biophysically constrain biodiversity via the fixation of amino acid substitutions in supercoiled DNA, which protects organized genomes from virus-driven pathology. Chirality (chemistry) Two enantiomers of a generic amino acid that is chiral The chirality of amino acids is energy-dependent…

Vietnam Veterans and others with glioblastoma

December 30, 2016

Adaptations, Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, Model Organisms, Neuronal Plasticity, Nutrigenomics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Variations, What's in the News

The Agent Orange Widows Club After their husbands died of an aggressive brain cancer, the widows of Vietnam veterans have found one another as they fight the VA for benefits. See also: Vietnam Veterans with Glioblastoma Multiforme Stage 4 Brain Cancer This post was removed: Targeting NF-κB in glioblastoma: A therapeutic approach This is the level of complexity that the VA needs to understand and link to the treatment of this aggressive cancer, which is obviously caused by virus-driven energy theft.…

Energy-dependent sensory maps (1996-2016)

December 30, 2016

Adaptations, Alternative Splicings, Autophagy, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations, What's in the News

Developmental broadening of inhibitory sensory maps My summary: They help to detail how olfactory input causes the energy-dependent de novo creation of sensory maps, which are representations of the external world. The experience-dependent representations link chemotaxis and phototaxis to biophysically constrained behavior. The representations are systematically organized in brain structures throughout development. Simply put, the maps are links from the epigenetic landscape to the physical landscape of supercoiled DNA in organized genomes. By investigating how ongoing neurogenesis in the mouse…

Energy-dependent oscillating gene networks organize life

December 26, 2016

Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations

Nascent, innate, intrinsic, and biofunctional are among the “weasel words” used by theorists who ignore the fact that all life-sustaining energy comes from the sun via hydrogen-atom transfer in DNA base pairs in solution. See how Jon Lieff continues to misrepresent that fact, by placing everything known about RNA-mediated cell type differentiation back into the context of evolution. Like all pseudoscientists, he starts with energy but fails to mention where the energy came from or where it goes when virus-driven…

2016 obfuscated facts about energy as information

December 23, 2016

Adaptations, Alternative Splicings, Ecology, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations

Illumination of the fluorescent biomarker in green revealed that the adult mouse brain could be infected by Zika in a region called the subgranular zone of the hippocampus. Full of neural progenitor cells, this part of the brain is important in learning and memory. Credit: Laboratory of Pediatric Brain Disease at The Rockefeller University/Cell Stem Cell As reported by Bob Yirka in: Best of Last Year – The top Medical Xpress articles of 2016 a team of MIT biologists reported…

More refutations of neo-Darwinian nonsense

December 23, 2016

Adaptations, Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations

New CRISPR–Cas systems from uncultivated microbes In bacteria, we discovered two previously unknown systems, CRISPR-CasX and CRISPR-CasY, which are among the most compact systems yet identified. Notably, all required functional components were identified by metagenomics, enabling validation of robust in vivo RNA-guided DNA interference activity in E. coli. Interrogation of environmental microbial communities combined with in vivo experiments allows access to an unprecedented diversity of genomes whose content will expand the repertoire of microbe-based biotechnologies. They discovered that energy-dependent RNA-mediated…

Re-inventing mutation-driven evolution (2)

December 20, 2016

Adaptations, Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, RNA Directed

See: Re-inventing mutation-driven evolution See also: Temperature regulates splicing efficiency of the cold-inducible RNA-binding protein gene Cirbp … we suspected that splicing efficiency, as defined by the fraction of pre-mRNA converted into mature mRNA, must have contributed to temperature-dependent Cirbp mRNA accumulation Splicing efficiency is energy-dependent in the context of temperature-dependent oscillations that link the sun’s anti-entropic virucidal energy to all biodiversity via Turing’s claims and my model. See also: The B/Z reaction, and the problem with peer review In…

Bio-functional information

December 17, 2016

Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations