RNA-mediated amino acid substitutions

Molecular Diagnostics: What is unprotected life? (2)

April 2, 2016
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
2 Comments

See also: Molecular Diagnostics: What is unprotected life? What is life when it is not protected from virus driven entropy Published on 30 Mar 2016. Presentated at Molecular Diagnostics on April 6 and 7, 2016 The poster also is available at Figshare POSTER (abstract) “The anti-entropic force of virucidal ultraviolet (UV) light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from…

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Molecular Diagnostics: What is unprotected life?

April 2, 2016
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
One Comment

Facile Recoding of Selenocysteine in Nature Abstract excerpt: This illustrates the ease by which the genetic code may evolve new coding schemes, possibly aiding organisms to adapt to changing environments, and show the genetic code is much more flexible than previously thought. My comment: It also refutes the ridiculous theories of neo-Darwinists, by placing ecological variation and ecological adaptation into the context of how nutrient-dependent RNA-mediated events are linked from the innate immune system to the physiology of reproduction and…

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Virus-driven sex differences?

April 2, 2016
James Kohl
Adaptations, Diseases & Disorders, Ecology, Human Brain, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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DNA methylation on N6-adenine in mammalian embryonic stem cells Excerpt: DNA methylation is a crucial component of epigenetic regulation that controls many important aspects of mammalian biology, such as imprinting, X chromosome inactivation and tumorigenesis1, 2. My comment: Nutrient-dependent RNA-directed DNA methylation links RNA-mediated amino acid substitutions to protein folding chemistry during thermodynamic cycles of energy dependent protein biosynthesis and degradation. Sex of a baby? Ancient virus makes the call Excerpt: …in other organisms, such as C elegans and the…

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Ricki Lewis’ Time Machine (4)

April 1, 2016
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
One Comment

Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan Excerpt: The signal we observe is driven by rs429358, a non-synonymous Cys112Arg variant, which defines the ε4 allele and which has not previously been shown to be the causal variant influencing lifespan. See also: Gorilla Genome 2.0: Lessons for the Clinic? Excerpt: VARIANTS OF UNCERTAIN SIGNIFICANCE With phrases such as “settled science” and “scientific proof” part of the lexicon, it’s little wonder that health care consumers expect…

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Creating and/or programming the immune system

March 31, 2016
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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A programming language for living cells Thanks to Fabricio Paes de Medeiros for calling attention to this example of an engineered innate immune system. The immune system links the epigenetic landscape to the physical landscape of supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. Excerpt: The sensors can detect different compounds, such as oxygen or glucose, as well as light, temperature, acidity, and other environmental conditions. My comment: It will be interesting to see…

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Energy-dependent RNA-mediated immunity (1)

March 4, 2016
James Kohl
Adaptations, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
2 Comments

Regulatory evolution of innate immunity through co-option of endogenous retroviruses Excerpt: The analysis revealed a primate-specific element that orchestrates the transcriptional response to interferons. Selection can therefore act on selfish genetic elements to generate novel gene networks. Reported as: A copy-and-paste gene regulatory network Excerpt: Chuong et al. provide evidence that concerted processes, involving endogenous retroviruses (ERVs), which are remarkably abundant in mammalian genomes, have contributed to the evolution of the regulatory systems that control the mammalian immune system (6).…

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NORAD: air defense and defense against genomic entropy

December 30, 2015
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
One Comment

NORAD may refer to: North American Aerospace Defense Command… that provides aerospace… defense for North America Norwegian Agency for Development Cooperation Noradrenaline, a hormone and a neurotransmitter with multiple biological roles My comment: The modern use of radar includes air-defense systems and ocean surveillance systems.  High tech radar systems are designed to use the systems complexity of signaling and sensing to extract useful information from levels of very high noise.  In the context of protection from virus-driven genomic entropy use…

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Human pheromone deniers: What’s next?

October 31, 2015
James Kohl
Adaptations, Alternative Splicings, Ecology, Human Pheromones, Model Organisms, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Variations
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Adapted from Human pheromones: What should these idiots do next? RNA-directed DNA methylation and RNA-mediated gene duplication and RNA-mediated amino acid substitutions link the nutrient-dependent physiology of pheromone-controlled reproduction to morphological and behavioral phenotypes in species from microbes to humans. Why would any serious scientist claim that there is a need to find human pheromones? Does any serious scientist not realize that the molecular mechanisms that link ecological variation to ecological adaptation must be the same in all living genera?…

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