RNA-mediated autophagy

The tipping point (revisited): 100K (3)

More than 100,000 indexed published works that mention microRNAs link the Creation of anti-entropic virucial light from light-activated microRNA biogenesis to RNA-mediated autophagy via the physiology of reproduction and biophysically constrained viral latency in all living genera. See for review: The tipping point (revisited): 100K (1) at MicroRNA-mediated.pro See for review: The tipping point (revisited): 100K (2) at Autophagy.pro Moving forward to what is known about how microRNAs are linked from RNAs to healthy longevity see: Autophagy regulation by microRNAs:…

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RNA-mediated nutritional psychiatry (2)

Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition The amino acid optimality code (Fig 6) provides an alternative perspective on sequence changes between paralogs in evolution and human disease. Neo-Darwinian theorists dispense with Darwin’s food energy-dependent  “conditions of life.” They link mutations and disease to evolution via mathematical models. They exemplify human idiocy. See for example: Neopterygian phylogeny: the merger assay Reported as: Adaptive radiations in the Mesozoic Bony fishes are the most diverse of all…

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RNA-mediated nutritional psychiatry

Summary: Young Genes are Highly Disordered as Predicted by the Preadaptation Hypothesis of De Novo Gene Birth Stop this nonsense about de novo gene birth and you will help to stop the school shootings without more gun control. See my presentation at the 2017 Precision Medicine Virtual Conference (2/15/17) Energy as information and constrained endogenous RNA interference See also: Pat Sweeney et al (3/13/2017) Protein misfolding in neurodegenerative diseases: implications and strategies.  A notable development is the creation of collaborative…

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Energy-dependent polycombic ecological adaptation

Are Humans Evolving Now Excerpt: This post will discuss current genetic data on what current evolution seems to be taking place. My comment: It is time for all science bloggers and journalists to stop making claims about evolution. None of their claims have ever been supported by experimental evidence of biologically-based energy-dependent top-down causation and the effects of energy on the physiology of reproduction in all living genera. For example: 1) Virus-driven energy theft is clearly the difference between bacteria…

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The natural success of RNAi and failed treatment

see my other blog posts on m6A Dynamics of Human and Viral RNA Methylation during Zika Virus Infection Excerpt: …ZIKV infection alters m6A location in mRNAs, methylation motifs, and target genes modified by methyltransferases. Our results identify a mechanism by which ZIKV interacts with and alters host cell functions. Reported as: Zika virus infection alters human and viral RNA Excerpt: When Zika virus infects a human cell, Rana’s team found, the cell modifies viral RNA with m6A as a means…

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