RNA-mediated cell type differentiation

Virus-driven cystinosis

May 1, 2018
James Kohl
Adaptations, base editing, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, RNA Directed, RNA editing, RNA interference, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
No Comments

A friend asked about nephropathic cystinosis, which is a disease caused by the virus-driven theft of quantized energy. All serious scientists have linked viruses from the degradation of messenger RNA to mutations and all pathology. Nephropathic cystinosis (NC) is the most frequent cause of Fanconi syndrome (FS) in young children. It will be linked from the virus-driven degradation of messenger RNA to azoospermia and/or progressive neuromuscular degeneration via the conserved molecular mechanisms of RNA-mediated cell type differentiation compared to mechanisms…

Read More

Abiogenesis vs microRNA biogenesis (3)

April 20, 2018
James Kohl
Adaptations, base editing, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
No Comments

Reappraising the human mitochondrial DNA recombination dogma   My comment to BioRxiv (Hold on, this is waiting to be approved by BioRxiv) Thank you for helping to show what has been missing from neo-Darwinian theories and other claims that were based on de Vries 1902 definition of mutation. Theorists may now want to learn more about the energy-dependent molecular mechanisms of recombination. Most of them will not like the findings you have provided. The peer-review process is especially deadly to…

Read More
An evolutionary theory killer

The eternal significance of microRNAs (3)

April 13, 2018
James Kohl
Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
No Comments

Summary:  RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment was not linked to sympatric speciation via The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression Something has gone horribly wrong.   I suspect the overwhelming ignorance of biologically uninformed theorists is the problem because their silence is deafening. When trapped by their ridiculous theories, they no longer kick, scream, or bite (like weasels). They participate in so-called marches like the 2018 March for…

Read More

Sympatric Speciation vs Pseudoscientific Nonsense (1)

April 7, 2018
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
No Comments

Summary: The “Science Behind the Game” from the cell biology game “Cytosis” supports all claims that clearly link energy-dependent alternative splicings of pre-mRNAs (aka microRNAs) to biophysically constrained viral latency. Game play by ages 10+ establishes the requirement for viral latency in the context of ecological variation and ecological adaptation outside the context of neo-Darwinian pseudoscientific nonsense. Simply put, Darwin presciently placed his “conditions of life” into the current perspective on ecological niche construction and sympatric speciation, which exemplifies ecological…

Read More

Part 2: Light-controlled cell biology (revisited)

March 23, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, RNA Directed
No Comments

Greg Bear took the lead with this approach in his novel Quantico (2006). A genetically engineered virus was used to erase the memory of a specifically targeted human population to reduce inter-ethnic conflict. [Greg Bear] …served as a consultant for NASA, the U.S. Army, the State Department, the International Food Protection Association, and Homeland Security on matters ranging from privatizing space to food safety, the frontiers of microbiology and genetics, and biological security. Greg Bear is a likely candidate for…

Read More

Ecological adaptation: a new definition of heredity (4)

March 9, 2018
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
No Comments

Experimentally Induced Metamorphosis in Axolotl (Ambystoma mexicanum) Under Constant Diet Restructures Microbiota Accompanied by Reduced Limb Regenerative Capacity (2018) Our results show that distinct bacterial communities inhabit individual organs of Axolotl and undergo substantial restructuring through metamorphosis. The restructuring during metamorphosis is biophysically constrained by feedback loops that link olfaction from food odors and pheromones to the creation of enzymes in bacteria and the secretion of the vertebrate decapeptide hormone GnRH (gonadotropin releasing hormone). See: Gonadotropin-releasing hormone agonist binding in…

Read More

The MicroRNAome Strikes Back: A Sokalian hoax (10)

February 1, 2018
James Kohl
Adaptations, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA-directed DNA methylation, Variations
No Comments

Linda Buck, Ben Feringa, Michael Gazzaniga, Christof Koch, Nick Lane and Svante Paabo are among the presenters who will almost undoubtedly discuss some or all of my claims. Prepare to ask questions or intelligently discuss accurate representations of top-down causation by watching this: The energy-dependent creation of the microRNAome protects the organized genomes of all living genera from the virus-driven degradation of messenger RNA that links mutations to all pathology. See: The Bull Sperm MicroRNAome and the Effect of Fescue…

Read More

From Autophagy.pro (transitions)

December 15, 2017
James Kohl
RNA Directed
No Comments

Summary: Who lets biologically uninformed theorists make presumptions about evolution after all serious scientists have linked light-harvesting from energy-dependent changes in electrons to ecosystems in all living genera via natural selection for food energy-dependent codon optimality. Who lets them pretend not to know that the pheromone-controlled physiology of reproduction links autophagy to the transgenerational epigenetic inheritance of healthy longevity? Who is causing the unnecessary suffering and premature death of your loved ones? Elsevier publishing supports the pseudoscientific nonsense touted by…

Read More

Achromobacter and killer theories

November 14, 2017
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Variations
No Comments

A pan-genomic approach to understand the basis of host adaptation in Achromobacter  Ecological variation is linked to food energy-dependent biophysically constrained viral latency by the pheromone-controlled physiology of reproduction in species from microbes to humans. For comparison, these authors claim: This study provides strong phylogenetic and pan-genomic bases to motivate further research on Achromobacter, and contributes to the understanding of opportunistic pathogen evolution. Their claim exemplifies how teaching neo-Darwinian theory causes unnecessary suffering and how it may cause the premature…

Read More
RSS Perfuming the Mind