RNA-mediated events

For God and Country

Sci-Hub vs limits on the dissemination of information

September 20, 2017
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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The ideology of “Americanism” is not consistent with the tactics of academics and politicians that constrain release of accurate information about  biologically-based cause and effect. …Americanism is an ideology, or belief in devotion, loyalty, or allegiance to the United States of America, or to its flag, traditions, customs, culture, symbols, institutions, or form of government.[2] In the words of Theodore Roosevelt, “Americanism is a question of spirit, conviction, and purpose, not of creed or birthplace.”[3] Americanism has two different meanings.…

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Wasted Templeton Funding (3)

April 22, 2016
James Kohl
Adaptations, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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See also: Wasted Templeton Funding (2) Templeton grant funds evolution rethink Excerpt: …parents can influence offspring not just through their DNA but by passing on the microorganisms they host or by transmitting epigenetic marks to subsequent generations. “Innovation may be a developmental response that becomes stabilized through genetic changes,” explains Armin Moczek, an evolutionary developmental biologist at Indiana University, Bloomington. My comment: He has not explained how nutrient energy-dependent changes in base pairs link hydrogen-atom transfer in solutions from microRNA…

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Ricki Lewis’ Time Machine (2)

January 24, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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See also: Can a Quirky Chromosome Create a Second Human Species? Reported here as: Ricki Lewis’ Time Machine Physics’s pangolin Trying to resolve the stubborn paradoxes of their field, physicists craft ever more mind-boggling visions of reality Excerpt 1) with my emphasis Physicists are deeply aware of the schizophrenic nature of their science and long to find a synthesis, or unification. Such is the goal of a so-called ‘theory of everything’. However, to non-physicists, these competing lines of thought, and…

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Another failed rescue attempt

January 16, 2016
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
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Social Darwinism, A Case of Designed Ventriloquism Excerpt:  In Wilson’s view, Social Darwinism “is perhaps the most important example of a term that became tainted and needs to be rescued.” According to him, from the very beginning, this term “was used as a pejorative to brand laissez faire policies that Darwin did not endorse. My comment: Darwin knew nothing about genetics. He stressed the fact that “conditions of life” must be placed before natural selection. Others ignored that fact and…

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Ecological genomics: teleophobes respond (too late)

January 11, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Forecasting Ecological Genomics: High-Tech Animal Instrumentation Meets High-Throughput Sequencing Conclusion: Twenty years ago, an essay about sequencing genomes and remotely tracking animals across the globe in real time would have been the subject of science fiction. In 2015, there are over 50,000 animals being tracked [12], and single research groups now sequence dozens, up to hundreds, of individual genomes [17,82]. By embracing new technology and integrating these data streams into an ecological genomic framework (Fig 1), we are now poised…

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Assumptions prove ignorance (2)

January 1, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, Pharmacogenomics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Neolithic and Bronze Age migration to Ireland and establishment of the insular Atlantic genome Conclusion: Hemochromatosis, known as the “Celtic” disease (44), is a variably penetrant recessive disorder, potentially fatal, due to excessive retention of dietary iron. It has been suggested that the high frequencies of both C282Y and H63D are due to heterozygote advantage related to nutritional advantage in Neolithic iron-poor diets (52), mitigation of celiac disease (53), and increased resistance to parasitic infection (54). To our knowledge, our…

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Unraveling the secrets of RNA-mediated events

November 10, 2015
James Kohl
Adaptations, Alternative Splicings, Ecology, Model Organisms, Nutrigenomics, Pharmacogenomics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Variations
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Unraveling the Secrets of DNA Excerpt: Belmont’s team will “rewire” chromosome regions to different nuclear locations and then determine the functional consequences of this rewiring. My comment: The “rewiring” can be placed into the context of nutrient-dependent pheromone-controlled rewiring of the genome that led to a report of over-the-weekend” re-evolution of the bacterial flagellum. Two nutrient-dependent amino acid substitutions linked the metabolic networks to the genetic networks and the RNA-mediated substitutions led to a second-chance resurrection of a functional structure.…

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Olfaction & the octopus and human genomes (2)

August 13, 2015
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, Physics, RNA Directed, Variations
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Darwinian evolution in the light of genomics Eugene Koonin excerpt: The distribution of evolutionary rates across sets of orthologous genes, the distribution of the sizes of paralogous gene families, the negative correlation between the expression level and the sequence evolution rate of a gene, and other relationships between key evolutionary and phenomic variables seem to be genuine universals of evolution. The simplicity of these universal regularities suggests that they are shaped by equally simple, fundamental evolutionary processes, rather than by…

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Viruses, amino acids, and somatic cell types

July 31, 2015
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, RNA Directed
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Although the ultimate origins of RNA viruses are uncertain, it seems reasonable to assume that these infectious agents have a long evolutionary history, appearing with, or perhaps before, the first cellular life-forms (38). The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis… Perhaps the evolutionists have placed the cart before the horse on this issue, as proposed by several…

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Protein folding and Google page rank

June 30, 2015
James Kohl
Adaptations, Ecology, Human Pheromones, Model Organisms
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Pheromones.com has been on the first page of a Google search for “pheromones” for several months. See: https://www.google.com/?gws_rd=ssl#q=pheromones Today, RNA-mediated.com appeared on the first page of a Google search for “RNA mediated” See: https://www.google.com/?gws_rd=ssl#q=RNA+mediated My domains may remain in a key position for information dissemination, or they may be placed into the background by Google’s algorithms. In either case, it has become clear that RNA-mediated events link the nutrient-dependent pheromone-controlled physiology of reproduction to biodiversity in species from microbes to…

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