RNA splicing

RNA-mediated nutritional psychiatry (2)

Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition The amino acid optimality code (Fig 6) provides an alternative perspective on sequence changes between paralogs in evolution and human disease. Neo-Darwinian theorists dispense with Darwin’s food energy-dependent  “conditions of life.” They link mutations and disease to evolution via mathematical models. They exemplify human idiocy. See for example: Neopterygian phylogeny: the merger assay Reported as: Adaptive radiations in the Mesozoic Bony fishes are the most diverse of all…

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RNA-mediated nutritional psychiatry

Summary: Young Genes are Highly Disordered as Predicted by the Preadaptation Hypothesis of De Novo Gene Birth Stop this nonsense about de novo gene birth and you will help to stop the school shootings without more gun control. See my presentation at the 2017 Precision Medicine Virtual Conference (2/15/17) Energy as information and constrained endogenous RNA interference See also: Pat Sweeney et al (3/13/2017) Protein misfolding in neurodegenerative diseases: implications and strategies.  A notable development is the creation of collaborative…

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From nitrogen atoms to ecosystems in all living genera

Summary: The “tiny machines” that “massacre viruses” link the creation of the anti-entropic virucidal energy of sunlight to the pheromone-controlled physiology of reproduction in all living genera via the nitrogen-dependent weekend resurrection of the bacterial flagellum in P. fluorescens. See: Virus-mediated archaeal hecatomb in the deep seafloor We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in…

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Sexual communication signals: New Insights!

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull New insights in the evolution of sexual communication signals Abstract excerpt: Our research focuses on identifying a) the genes underlying sexual signals and responses in both sexes2-4, and b) ecological factors that may cause divergence in…

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RNA splicing, genetic variation, and disease

More than 600 blog posts on this domain attest to the fact that nutrient energy-dependent RNA-mediated cell type differentiation is the key to healthy longevity in all living genera. Only those who have missed the accurate representations of others who have linked angstroms to ecosystems via the innate immune system, the physiology of reproduction, and supercoiled DNA will continue to place RNA splicing into the context of disease, without acknowledging that RNA splicing is the key to Precision Medicine. RNA…

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Bacteria see the light and they adapt

Cyanobacteria use micro-optics to sense light direction Excerpt: From the observed dimensions of the spot of 488 nm light focused by Synechocystis cells (Figure 3c) we can estimate that Synechocystis “vision” has an angular resolution (FWHM) of about 21°, essentially limited by light wavelength and the area of the plasma membrane, which is tiny in comparison to an animal retina. However, this resolution is sufficient to incorporate quite complex spatial information into a 360° image of the cell’s surroundings, and…

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Non-mainstream scientist shares Nobel prize in Medicine

Youyou Tu is the 12th women awarded the Nobel Prize in Physiology or Medicine (2015) for her discoveries concerning a novel therapy against Malaria. Historical perspective: Lasker~DeBakey Clinical Medical Research Award Excerpt: Tu discovered a passage in the Handbook of Prescriptions for Emergencies (340 CE) by Ge Hong that referenced Qinghao’s malaria-healing capacity. It said “Take a handful of Qinghao, soak in two liters of water, strain the liquid, and drink.” She realized that the standard procedure of boiling and…

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Is SUMOylation RNA-directed DNA methylation?

System-wide identification of wild-type SUMO-2 conjugation sites Excerpt: SUMOylated proteins were found to be predominantly nuclear, and involved in chromatin remodelling, RNA splicing, transcription and DNA repair. When compared with other SUMOylation studies, a significant overlap with PRISM-identified SUMO sites (48%) and SUMO target proteins (85%) was confirmed. We discovered one-fifth of the PRISM-identified SUMOylated lysines to overlap with ubiquitylation and acetylation. My comment: SUMOylation appears to be a new name for RNA-directed DNA methylation, which links nutrient-dependent RNA-mediated amino…

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