RNA SYNTHESIS

NSF’s parrot and other parrots

Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964) “Isolated thymus nuclei transport amino acids into an intranuclear pool by a process which seems to depend on energy from nuclear ATP synthesis (20).” The energy must be biophysically constrained: Long-range coherence and energy storage in biological systems (1968) Human Pheromones: Linking Neuroendocrinology and Ethology (revisited) (2010) Slide # 6 attests to the fact that the levels of biological organization…

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The MicroRNAome Strikes Back: A Sokalian hoax (9)

Summary: Darwin’s “conditions of life” link the creation of sunlight from the creation of ATP to the creation of microRNAs and RNA-mediated cell type differentiation in the context of biophysically constrained viral latency. There is no magical creation of an RNA force field or protein force field that could be used to link the magic of evolution to biologically-based diversity in species from microbes to humans. RNA force field with accuracy comparable to state-of-the-art protein force fields The complex and…

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Interethnic genetic similarities and differences (2)

From Massivesci.com Simulating evolution helped scientists design a better virus: It sounds like an arcane superpower. It boils down to random mutation and selection  January 9, 2018 See also: In an information ecosystem that grows ever more politically siloed, such lines of study are worth pursuing. January 11, 2018 Information ecosystems are energy-dependent. See: MicroRNA + cadherin The creation of adhesion proteins prevents genomic entropy. On January 11, 2018 Nadja (Chief Content Officer) from Massivesci.com wrote: We’re in the midst…

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A mental health problem at the highest level

Investigators look for clues in deadly church shooting – news – att.net Investigators look for clues in deadly church shooting – news – att.net Todd Piro reports from Sutherland Springs, Texas. …the result of a “mental health problem at the highest level.” The mental health problem is caused by the virus-driven degradation of messenger RNA, and by the ignorance of theorists who claim that mutations cause evolution. The theorists may not be intelligent enough to play the cell biology game…

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Exome Sequencing Impact in Routine Care

Summary: They placed the pseudoscientific nonsense about selection for beneficial mutations into the context of positive selection for mutations, which are caused by the virus-driven degradation of messenger RNA. The mutations have been linked to all pathology. It’s as if all theorists want to become known as “biologically uninformed science idiots” via their associations with others who have touted claims about “beneficial mutations.” US Air Force Studying Impact of Exome Sequencing in Routine Care Who, among my fellow veterans, and…

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Losers: rediscovering an epigenetic key

Epigenetic mechanisms modulate differences in Drosophila foraging behavior Little is known about how genetic variation and epigenetic marks interact to shape differences in behavior. Reported as: An epigenetic key to unlock behavior change October 16, 2017 “One of the big questions in the Child & Brain Development program over the years has been how experience gets embedded in our biology and the mechanisms for that,” says Sokolowski. See for comparison: See Brain on stress: How the social environment gets under…

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For God and Country

Energy-dependent structure and function: Until death (3)

Energy-dependent structure and function: Until death (2) The COMT Val158Met polymorphism supposedly is not found in species other than humans See: Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles This is also the first study establishing the COMT*L allele as the derived allele unique to humans. Other organisms do not commit suicide. That suggests the human specific COMT Val158Met substitution may be important to those who know very little about suicide prevention. For instance, see: The catechol-o-methyltransferase Val158Met polymorphism…

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For God and Country

Energy-dependent structure and function: Until death (2)

Energy-dependent structure and function: Until death (1) Terry Crews details alleged sexual assault by ‘high level’ Hollywood exec “This whole thing with Harvey Weinstein is giving me PTSD. Why? Because this kind of thing happened to ME…” Crews tweeted Tuesday. This claim helps to link the celebrity status of Hollywood victims like Robin Williams to the suicide rate in veterans who have returned from military service overseas with viruses. The viruses clearly link energy-dependent changes in the microRNA/messenger RNA balance…

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For God and Country

Energy-dependent structure and function: Until death (1)

The structure-energy landscape of NMDA receptor gating …using single-molecule Forster resonance energy transfer (smFRET), we map the energy landscape of the first transmembrane segment of the Rattus norvegicus NMDA receptor under resting and various liganded conditions. These results show kinetically and structurally distinct changes associated with apo, agonist-bound, and inhibited receptors linked by a linear mechanism of gating at this site. Furthermore, the smFRET data suggest that allosteric inhibition by zinc occurs by an uncoupling of the agonist-induced changes at…

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