RNA

An evolutionary theory killer

ATP and RNA-mediated chromosomal stability

May 9, 2018
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic
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Cytosis, a cell biology game for ages 10+ links ATP to viral latency and the protection of all organized genomes from the virus-driven degradation of messenger RNA that serious scientists have linked to all pathology. It is time for a new measure of cell function: Quantifying Cellular ATP Production Rate…(2018) Adenosine triphosphate (ATP) is the most common high energy intermediate of living organisms. Cells utilize the energy derived from the breakdown of cellular fuels to synthesize ATP from ADP and…

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An evolutionary theory killer

The eternal significance of microRNAs (3)

April 13, 2018
James Kohl
Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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Summary:  RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment was not linked to sympatric speciation via The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression Something has gone horribly wrong.   I suspect the overwhelming ignorance of biologically uninformed theorists is the problem because their silence is deafening. When trapped by their ridiculous theories, they no longer kick, scream, or bite (like weasels). They participate in so-called marches like the 2018 March for…

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Autophagy is the antiphage defense strategy (2)

January 17, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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2/15/17 Energy as information and constrained endogenous RNA interference (video) The 6.46 minute-long technical presentation (above) from the Precision Medicine Virtual Conference is difficult to understand.Thus, 10 months later, Nik Willmore asked: 12/24/17 What are your insights into CRISPR and mTOR, for a young audience? I’m not mocking you…yet, Humpty Dumpty. What is the basis of your unifying principle? Vibration? Bohmian morphogenetic fields? Modified Darwin? God? –Nik Willmore @nikwillmore 12/25/17 Replying to @nikwillmore @jhewitt123 God created the anti-entropic virucidal energy of sunlight and…

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Enzyme-constrained interethnic diversity (7)

January 15, 2018
James Kohl
Adaptations, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, RNA Directed, RNA editing, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity
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Summary:  I suspect that John Hewitt will soon publish an article on the energy-dependent creation of microRNAs and enzymes. He is most likely to link the virus-driven theft of quantized energy as information to all pathology without challenging pseudoscientists and other science journalists to revise their ridiculous claims about mutation-driven evolution. Digital medicine, on its way to being just plain medicine There are already nearly 30,000 peer-reviewed English-language scientific journals, producing an estimated 2.5 million articles a year. Until recently,…

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A Mathematical Model Links Quantum Physics to Quantum Souls (2)

January 4, 2018
James Kohl
Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
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See for review: A Mathematical Model Links Quantum Physics to Quantum Souls (1) See for comparison: Zaugg Lab We are applying and developing computational biology tools for integrating large-scale biological ‘omics data to address questions in personalised genomics. The Zaugg Lab ignores everything known to serious scientists about energy-dependent top-down causation, which is the only way to link quantum physics to biophysically constrained biologically-based biodiversity. Watch them try to do that with a mathematical model, instead. Loops in DNA affect which proteins are coded …

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Schrodinger’s answer to Schrodinger’s question

November 21, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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There is no such thing as de novo control of electrons or self-assembly. Answering Schrödinger’s question: A free-energy formulation The free-energy principle (FEP) is a formal model of neuronal processes that is widely recognised in neuroscience as a unifying theory of the brain and biobehaviour. More recently, however, it has been extended beyond the brain to explain the dynamics of living systems, and their unique capacity to avoid decay. They don’t understand the question that Schrodinger answered. He linked the…

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MicroRNAs and the Cassandra syndrome (revisited)

November 20, 2017
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, microRNA editing, Model Organisms, Nutrigenomics, RNA methylation, RNA-directed DNA methylation, Variations
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Conclusion: Serious scientists can explain every aspect of energy-dependent biophysically constrained viral latency in the context of details about these pathways and everything that links changes from electrons to ecosystems in all living genera. Why are the serious scientists still challenged by “…the tendency of academia to reject any academic-like work from outside academia?” What aspect of the academic contribution that could lead to the cure for all pathology do biologically uninformed academics want to continue to reject and attack?…

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A null mutation and healthy longevity?

November 17, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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Summary: Food odors and pheromones biophysically constrain all pathology in species from microbes to humans. What kind of biologically uninformed science idiot leaves out everything known to serious scientists about the virus-driven degradation of messenger RNA and tells others they must falsify the neutral null theory that led to claims about a biophysically constrained beneficial “null mutation” in the Amish population of Berne, Indiana? Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia Reported as: How to Control…

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Robert Sapolsky’s legacy of atheistic pseudoscientific nonsense

August 12, 2017
James Kohl
Adaptations, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Variations
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Summary: Not only does everything known to serious scientists about energy link RNA synthesis to life, everything McEwen and others have published links nutrient stress and/or social stress to the virus-driven degradation of messenger RNA and all pathology. As moderator of the International Society for Human Ethology (ISHE), a not-for-profit scientific organization that consistently touts pseudoscientific nonsense in the context of neo-Darwinian evolution, Jay R. Feierman’s attacks on the works of serous scientists are increasing in frequency and in magnitude.…

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Automagical protein creation sans energy

August 10, 2017
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity
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Summary: The creation of the enzyme is linked to the evolution of all biodiversity via the creation of the enzyme and mutations. See for comparison: Neuronal-expressed microRNA-targeted pseudogenes compete with coding genes in the human brain. Listen to this song about Santa Claus and note that he sees you when you’re sleeping and somehow unconsciously determines if you’ve been good or bad. Santa Claus may know that the sense of smell has repeatedly been linked to effects on hormones and unconscious…

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