RNAi

God’s microRNA-mediated Creation of genotypes (3)

Commentary: Origin and evolution of pathogenic coronaviruses 4/21/20 Both fieldworks and experimental biology are required to understand the viruses concomitantly with predicting or preventing potential outbreaks. On 4/23/20 former President Trump linked God’s Creation of sunlight and humidity to weakened #COVID19 and the end or effective treatment of all virus-driven pathology via RNA interference (#RNAi). See for comparison: Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues  5/25/21 Reported as:…

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Natural selection for adaptation (10)

See: Ignoring light-activated microRNA biogenesis 10/16/18, and compare our section on pre-mRNAs and molecular epigenetics in: From Fertilization to Adult Sexual Behavior (1996) to MicroRNAs buffer genetic variation at specific temperatures during embryonic development 10/16/18, which was previously published sans mention of microRNAs as Temporal development of Drosophila embryos is highly robust across a wide temperature range 7/11/18 Changing the term from pre-mRNAs to microRNAs obfuscated food energy-dependent pheromone-regulated genetic processes of cause and effect, but see ~127,000 indexed publications…

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microRNA-mediated replication cycles (9)

See first: microRNA-mediated replication cycles (8) Rotavirus research: 2014-2020 7/2/21 A temperature sensitive mutant… in the triplet encoding amino acid 138 of VP1 (L138P)…was separately expressed as a… protein, shown to interact with viroplasm-like particles (VLPs) in uninfected cells and to synthesize RNA in vitro…” My summary: The rotavirus steals the energy required for the ATP-dependent synthesis of RNA, which typically biophysically constrains viral latency across kingdoms. Contextual constraints occur via light-activated carbon fixation, oxidative phosphorylation and RNA interference (RNAi).…

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microRNA-mediated replication timing (3)

miRNAs; a novel strategy for the treatment of COVID-19 6/28/21 Several previous studies have shown that host miRNAs play an anti-viral role and improve the treatment of patients with COVID-19. miRNAs by binding to the 3′-UTR or 5′-UTR of viral RNA play an important role in COVID-19-host interplay and viral replication. That fact makes it easier to convict Facebook of crimes against humanity because their censors prevent me from including links to autophagy.pro, and to microRNA.pro which expose the scientific…

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Coherently organized healthy longevity (1)

A large-scale binding and functional map of human RNA-binding proteins [RBPs] 7/29/20 We describe the spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization. These data expand the catalogue of functional elements encoded in the human genome by the addition of a large set of elements that function at the RNA level by interacting with RBPs. Reported as: ENCODE consortium identifies RNA…

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The microRNA-mediated future of humanity (8)

The levels of complexity linked to the microRNA-mediated future of humanity can be examined by ages 10-14+ via game-play of: Bacillus (failed project) See instead: Function of miR825 and miR825* as Negative Regulators in Bacillus cereus AR156-elicited Systemic Resistance to Botrytis cinerea in Arabidopsis thaliana 10/17/19 Peptide Players compete to link amino acids to build a peptide chain (a fancy word for a protein). Virulence Players take on the role of viruses and compete to infect a host cell in…

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Autophagy is the antiphage defense strategy (2)

2/15/17 Energy as information and constrained endogenous RNA interference (video) The 6.46 minute-long technical presentation (above) from the Precision Medicine Virtual Conference is difficult to understand.Thus, 10 months later, Nik Willmore asked: 12/24/17 What are your insights into CRISPR and mTOR, for a young audience? I’m not mocking you…yet, Humpty Dumpty. What is the basis of your unifying principle? Vibration? Bohmian morphogenetic fields? Modified Darwin? God? –Nik Willmore @nikwillmore 12/25/17 Replying to @nikwillmore @jhewitt123 God created the anti-entropic virucidal energy of sunlight and…

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Quantized energy-dependent viral trophism (3)

Summary: If the pathway is ancestral, how and when did it evolve to protect species from microbes to humans from the virus-driven degradation of their messenger RNA? Peer-Reviewed Science: A “Mathematical Proof of Darwinian Evolution” Is Falsified The theorem addresses only the effects of natural selection. Fisher did not directly address any other effect (mutation, genetic drift, environmental change, etc.) as he considered them to be insignificant. Later mathematicians took issue with Fisher’s lack of rigor, some at considerable length.…

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For God and Country

Sci-Hub vs limits on the dissemination of information

The ideology of “Americanism” is not consistent with the tactics of academics and politicians that constrain release of accurate information about  biologically-based cause and effect. …Americanism is an ideology, or belief in devotion, loyalty, or allegiance to the United States of America, or to its flag, traditions, customs, culture, symbols, institutions, or form of government.[2] In the words of Theodore Roosevelt, “Americanism is a question of spirit, conviction, and purpose, not of creed or birthplace.”[3] Americanism has two different meanings.…

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The billion dollar baby (revisited)

Summary: All energy-dependent differences in the microRNA/messenger RNA balance have now been linked from the physiology of pheromone-controlled reproduction to all morphological and behavioral phenotypes by the conserved molecular mechanisms of RNA-mediated cell type differentiation. FDA Approves Treatment That Modifies Patient’s Own Genes To Fight Cancer It costs $475,000 and the treatment could kill you. Discussion attempt  Keep in mind that you could have stopped this. Now, you either continue to play their game, or play the cell biology game…

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