Roger Gorski

Selfish X-linked alleles and X chromosome inactivation

From Fertilization to Adult Sexual Behavior In our section on molecular epigenetics from 1996 we wrote: Genomic-imprinting is also manifest in specific parts of the X-inactivation region’s related XIST gene. Here male- and female-specific methyl-group patterns participate in X-inactivation in females and also in the preferential inactivation of the paternal X in human placentae of female concepti (Harrison, 1989; Monk, 1995). This process indicates that tissues of the early conceptus can sense and react differentially to epigenetic sexual dimorphisms on…

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Xist-ing on planet Earth

Sex Differences in the Brain (revisited) A comment that was complementary led me to add this: Ideas about evolutionary processes that automagically led to sex differences in cell types can be dissmissed in the light of experimental evidence of biologically-based cause and effect. Since 1996, for example, serious scientists have known about the role of Xist in chromosome inactivation. See also, from 2015:An Xist-activating antisense RNA required for X-chromosome inactivation In our Hormones and Behavior review we (TB) wrote: “Genomic-imprinting…

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